Figures & data
Table 1 Characteristics and Clinical Detection Indices of the Total Study Population
Figure 1 The serum concentrations of IL-26 were quantitatively examined by ELISA.
Notes: ****p ≤ 0.0001 versus healthy controls or neurosyphilis patients; NS = not significant; and U-Mann–Whitney test. Each data point indicates an individual subject, and error bars and medians with interquartile ranges are displayed by red lines.
Figure 2 The associations between the levels of serum IL-26 and clinical routine hematological and humoral indices in healthy subjects and syphilis patients are presented in the form of a heatmap.
Notes: *p ≤ 0.05, **p ≤ 0.01 were considered statistically significant with clinical routine hematological and humoral indices in syphilis patients. Heatmap representation of the correlations between the levels of serum IL-26 and RBC, HGB, HCT, RDW-SD, PLT, WBC, NEUT, LYM, NLR, PLR, MO, EO, BA, MPV, PDW, PCT, p-LCR, uGLU, KET, uPRO, SG, UpH, BLD, uRBC, uWBC, SPC, TPC, KLG, ALT, AST, ALB, ALP, TB, DB, UREA, CR, TG, TC, LDLC, GLU, CK, LDH, GLB, (A)G, (A)A, GGT, IBIL, (B)C, HDL, EGFR-C, APTT, PT, INR, TT, FIB and D-dimer levels in healthy subjects (n = 30, Pearson coefficient), neurosyphilis patients (n = 33, Pearson coefficient), late latent syphilis patients (n = 43, Pearson coefficient), seroresistant syphilis patients (n = 45, Pearson coefficient) and secondary syphilis patients (n = 45, Pearson coefficient).
Abbreviations: RBC, red blood cell; HGB, hemoglobin concentration; HCT, hematocrit; RDW-SD, red blood cell distribution width; PLT, platelets; WBC, white blood cell; NEUT, neutrophils; LYM, lymphocytes; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; MO, monocytes; EO, eosinophils; BA, basophils; MPV, mean platelet volume; PDW, platelet distribution width; PCT, plateletcrit; P-LCR, platelet-large cell ratio; uGLU, urine glucose; KET, urine ketone; uPRO, urine protein; SG, urine specific gravity; UpH, urinary pH; BLD, urinary occult blood; uRBC, urinary red blood cell count; uWBC, urinary white blood cell count; SPC, urine epithelial cell count; TPC, bacterial count; KLG, cast count; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; ALP, alkaline phosphatase; TB, total bilirubin; DB, direct bilirubin; GLB, globulin; Cr, creatinine; TG, triglyceride; TC, total cholesterol; LDLC, low-density lipoprotein cholesterol; Glu, blood glucose; CK, creatine kinase; LDH, lactate dehydrogenase; A:G, albumin globulin ratio; A:A, AST-to-ALT ratio; GGT, glutamyltranspeptidase; IBIL, indirect bilirubin; B:C, BUN/Cr; HDL, high-density lipoprotein; EGFR-C, epidermal growth factor receptor C; APTT, activated partial thromboplastin time; PT, prothrombin time; INR, international normalized ratio; TT, thrombin time; FIB, fibrinogen.
Figure 3 Correlation between serum IL-26 and TRUST titers in different stages of syphilis.
Notes: The correlation coefficient R represents the linear correlation between serum IL-26 levels and TRUST titers in each experimental group. When the absolute value of R is greater than 0.75 and the p value is ≤0.05, there is considered to be a strong linear correlation.
