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ORIGINAL RESEARCH

Comparative Analysis of Epidemiological and Clinical Characteristics Between Invasive Candida Infection versus Colonization in Critically Ill Patients in a Tertiary Hospital in Anhui, China

, , , &
Pages 3905-3918 | Published online: 23 Jul 2022

Figures & data

Table 1 PCR primers used in the study

Table 2 Strain-distribution patterns of invasive Candida infection vs colonization

Figure 1 Data of the identification of Candida strains obtained from the present research. (A) MALDI-TOF MS analysis of Candida spp. typically involved in the present study. (B) Microscopically analyzed fungal fluorescent staining results of representative Candida spp. cultured on Sabouraud dextrose/chromogenic agar plates.

Abbreviations: CAL, C. albicans; CGL, C. glabrata; CTR, C. tropicalis; CPA, C. parapsilosis; CKR, C. krusei.
Figure 1 Data of the identification of Candida strains obtained from the present research. (A) MALDI-TOF MS analysis of Candida spp. typically involved in the present study. (B) Microscopically analyzed fungal fluorescent staining results of representative Candida spp. cultured on Sabouraud dextrose/chromogenic agar plates.

Table 3 Comparison of clinical variables of invasive Candida infections vs controls

Table 4 Comparison of clinical variables of Candida colonization vs controls

Table 5 Comparison of clinical variables of invasive Candida infection vs colonization

Table 6 Antifungal-sensitivity patterns of patients with invasive Candida infection and colonization

Figure 2 Data of homologous 3D-structure modeling for putatively mutant ERG11 gene products in Candida spp. assisted by 5JLC as template (http://www.pdb.org). Presumably altered 3D steric conformations of ERG11 enzymes from azole-resistant C. albicans (A), C tropicalis (B), and C. parapsilosis (C) are shown. Red spots indicate mutation sites at the amino-acid level in each Candida spp. resistant against azoles when compared with corresponding reference sequences in GenBank.

Abbreviations: CAL, C. albicans; CTR, C. tropicalis; CPA, C. parapsilosis.
Figure 2 Data of homologous 3D-structure modeling for putatively mutant ERG11 gene products in Candida spp. assisted by 5JLC as template (http://www.pdb.org). Presumably altered 3D steric conformations of ERG11 enzymes from azole-resistant C. albicans (A), C tropicalis (B), and C. parapsilosis (C) are shown. Red spots indicate mutation sites at the amino-acid level in each Candida spp. resistant against azoles when compared with corresponding reference sequences in GenBank.