Risk Factors for Mortality in Hospitalized Patients with Stenotrophomonas maltophilia Bacteremia

Figures & data

Table 1 Overall Characteristics and Univariate Analysis of Mortality in Patients with S. maltophilia Bacteremia

Variables	Total n=51 (%)	Survived n=32 (%)	Death n=19 (%)	P-value
Age, years, median, IQR	74.65 (66.00–88.00)
≥65	11 (21.6)	9 (28.1)	2 (10.5)	0.260
<65	40 (78.4)	23 (71.9)	17 (89.5)
Gender
Male	40 (78.4)	26 (81.3)	14 (73.7)	0.777
Female	11 (21.6)	6 (18.8)	5 (26.3)
Hospital stay, days, mean±SD	39.86±49.240	40.69±45.629	38.47±56.090	0.878
Main diagnosis
Sepsis	29 (56.9)	15 (46.9)	14 (73.7)	0.062
Pulmonary disease	41 (80.4)	22 (68.8)	19 (100)	0.019
Cardiovascular disease	44 (86.3)	26 (81.3)	18 (94.7)	0.176
Diabetes mellitus	37 (72.5)	22 (68.8)	15 (78.9)	0.430
Chronic liver disease	4 (7.8)	2 (6.3)	2 (10.5)	0.583
Chronic kidney disease	21 (41.2)	9 (28.1)	12 (63.2)	0.014
Solid tumor	15 (29.4)	7 (21.9)	8 (42.1)	0.125
Neurologic diseases	29 (56.9)	17 (53.1)	12 (63.2)	0.484
Shock	29 (56.9)	13 (40.6)	16 (84.2)	0.002
Invasive Procedure
Central venous catheter	46 (90.2)	27 (84.4)	19 (100)	0.070
Mechanical ventilator	32 (62.7)	20 (62.5)	12 (63.2)	0.963
Drainage tubing	8 (15.7)	5 (15.6)	3 (15.8)	0.988
Foley catheter	40 (78.4)	21 (65.6)	19 (100)	0.011
Source of bacteremia
Sputum	23 (45.1)	16 (50.0)	7 (36.8)	0.361
APACHE II score, mean±SD	23.94±6.828	22.41±6.633	28.21±4.803	<0.001
Laboratory findings
CRP (mg/L), mean±SD	96.786±57.495	84.183±43.121	114.696±70.721	0.076
PCT(ug/L), mean±SD	3.361±5.122	2.222±3.806	5.260±6.459	0.045
Prior antimicrobial therapy
Carbapenem	27 (52.9)	14 (43.8)	13 (68.4)	0.088
Antifungal agent	25 (49.0)	12 (37.5)	13 (68.4)	0.033
Specific therapy	29 (56.9)	17 (53.1)	12 (63.2)	0.484
Antimicrobial therapy after bacteremia
Appropriate specific therapy	40 (78.4)	27 (84.4)	13 (68.4)	0.324

Abbreviations: APACHE II, Acute Physiology and Chronic Health Evaluation II; CRP, C-reactive protein; PCT, Procalcitonin.

Table 2 Multivariate Analysis of Factors Associated with 28-Day Mortality in Patients with S. maltophilia Bacteremia

Factor	OR (95% CI)	P-value
APACHE II	1.211 (1.061, 1.382)	0.005

Abbreviations: APACHE II, Acute Physiology and Chronic Health Evaluation II; OR, odds ratio; CI, confidence interval.

Table 3 Antibiotic Susceptibility of Stenotrophomonas maltophilia Isolates

Antibiotics	n	Susceptible (%)	Intermediately Susceptible (%)	Resistant (%)
Ticarcillin clavulanate	17	29.4	58.8	11.8
Ceftazidime	31	22.6	16.1	61.3
Levofloxacin	51	78.4	5.9	15.7
Trimethoprim sulfamethoxazole	51	92.2	0	7.8
Minocycline	19	94.7	0	5.3