https://orcid.org/0000-0002-8107-1737
Figures & data
Table 1 Antibiotic Susceptibility Pattern of K. pneumoniae Isolates by Disk Diffusion Method (n=73)
Table 2 Risk Factors Associated with VAP Caused by CR K. pneumoniae Isolates
Table 3 Carbapenemase Genes Detected in CR K. pneumoniae Isolates and the Corresponding mCIM and eCIM Results (n=52)
Figure 1 Results of mCIM/eCIM test of 2 CR K. pneumoniae isolates. The two isolates show positive mCIM/eCIM test results indicating MBL production.
Figure 2 PCR results for carbapenemase genes. (A) Agarose gel electrophoresis of blaKPC and blaOXA-48 amplicons. Lane (1): DNA ladder 100 bp, lanes (2, 5, 6, 7): positive for blaOXA-48 gene (438bp), lane (8): positive for blaKPC gene (789bp). (B) Agarose gel electrophoresis of blaNDM amplicons. Lane (1): DNA ladder 100 bp, lanes (2–4): positive for blaNDM gene (621bp).
Table 4 The Effect of Meropenem–Ciprofloxacin and Meropenem–Colistin Combinations on CR K. pneumoniae Isolates (n = 52)
Figure 3 Meropenem–colistin combination testing. This was a synergistic effect. Meropenem MIC was >32 μg/mL when tested alone but was 0.25 μg/mL in combination. Colistin MIC was 8 μg/mL when tested alone but was 1.5 μg/mL in combination.
Table 5 Antibiotics Susceptibility Pattern of Carbapenem-Resistant K. pneumoniae Isolates to New Antibiotics According to Their Carbapenemase Genes (n=52)