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Infection and Drug Resistance Volume 15, 2022 - Issue
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ORIGINAL RESEARCH

The Relevance of Host Gut Microbiome Signature Alterations on de novo Fatty Acids Synthesis in Patients with Multi-Drug Resistant Tuberculosis

Jichan Shi1 Department of Infectious Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaView further author information
,
Gexin Gao2 Department of Nursing School, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaView further author information
,
Zhijie Yu3 Department of Hematology, Wenzhou Key Laboratory of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, People’s Republic of ChinaView further author information
,
Kaihuai Wu4 Departments of Infectious Diseases, Taishun People’s Hospital, Wenzhou, 325000, People’s Republic of ChinaView further author information
,
Youquan Huang5 Departments of Infectious Diseases, Yongjia People’s Hospital, Wenzhou, 325000, People’s Republic of ChinaView further author information
,
Lian-Peng Wu6 Department of Laboratory, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaView further author information
,
Zhengxing Wu1 Department of Infectious Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaView further author information
,
Xinchun Ye1 Department of Infectious Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaView further author information
,
Chaochao Qiu1 Department of Infectious Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaView further author information
&
Xiangao Jiang1 Department of Infectious Disease, Wenzhou Central Hospital, The Dingli Clinical Institute of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of ChinaCorrespondence[email protected]
View further author information
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Pages 5589-5600 | Received 06 May 2022, Accepted 19 Aug 2022, Published online: 21 Sep 2022

Figures & data

Table 1 Basic information of 62 patients with active TB

Table 2 Basic information of healthy individuals

Table 3 Primer Sequences for Real-Time PCR

Figure 1 Diversity of gut microbiota in each patients with RR-TB, Pre-XDR, MDR-TB and healthy individuals.

Abbreviations: MDR-TB, multi-drug resistant TB; pre-XDR-TB, pre-extensively drug-resistant TB; RR-TB, rifampicin-resistant TB, Con, control.
Figure 1 Diversity of gut microbiota in each patients with RR-TB, Pre-XDR, MDR-TB and healthy individuals.

Figure 2 Variety differences of gut microbiome (different treatments vs healthy individuals).

Notes: Data are represented as means ± SD of three independent experiments. *p < 0.05.
Abbreviations: MDR-TB, multi-drug resistant TB; pre-XDR-TB, pre-extensively drug-resistant TB; RR-TB, rifampicin-resistant TB, Con, control.
Figure 2 Variety differences of gut microbiome (different treatments vs healthy individuals).

Figure 3 Distribution of gut microbiome in different subjects at the phylum level.

Abbreviations: MDR-TB, multi-drug resistant TB; pre-XDR-TB, pre-extensively drug-resistant TB; RR-TB, rifampicin-resistant TB, Con, control.
Figure 3 Distribution of gut microbiome in different subjects at the phylum level.

Figure 4 Distribution of gut microbiome in different subjects at the order level.

Abbreviations: MDR-TB, multi-drug resistant TB; pre-XDR-TB, pre-extensively drug-resistant TB; RR-TB, rifampicin-resistant TB, Con, control.
Figure 4 Distribution of gut microbiome in different subjects at the order level.

Figure 5 Distribution of gut microbiome in different subjects at the family level.

Abbreviations: MDR-TB, multi-drug resistant TB; pre-XDR-TB, pre-extensively drug-resistant TB; RR-TB, rifampicin-resistant TB, Con, control.
Figure 5 Distribution of gut microbiome in different subjects at the family level.

Figure 6 Differences of mRNA expression of CPT1, GAPDH, FASN and ACC1 in de novo synthesis of fatty acids.

Notes: Data are represented as means ± SD of three independent experiments.*p < 0.05 and **p < 0.01.
Abbreviations: MDR-TB, multi-drug resistant TB; pre-XDR-TB, pre-extensively drug-resistant TB; RR-TB, rifampicin-resistant TB, Con, control.
Figure 6 Differences of mRNA expression of CPT1, GAPDH, FASN and ACC1 in de novo synthesis of fatty acids.

Figure 7 Recommended pathway of de novo synthesis of fatty acids.

Abbreviations: FAS, Fatty acid synthesis; TCA, Tricarboxylic acid cycle; mTORC, Mammalian target of rapamycin; SREBP, Sterol-regulatory element binding proteins; LCFA, Long- Chain Fatty Acid.
Figure 7 Recommended pathway of de novo synthesis of fatty acids.

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