A Retrospective Study of Clinical Efficacy of Cantharidin Cream for Verruca Plantaris

Figures & data

Table 1 Four-Week Follow-Up to Assess Clinical Efficacy of Verrucae Plantaris Treatment

Group	Number	Sex		Mean Age (Years)	Number of Warts		Outcome (Follow-up After 4 Weeks)			P-value
		M	F		Single	Multiple	Clinically Cured	Clinical Recurrence	Clinical Efficiency (%)
Cantharidin treatment	50	28	22	34.02±16.01	20	30	46	4	92.0	0.225 (>0.05)
CO2 laser treatment	50	30	20	33.25±8.00	30	20	42	8	84.0
Liquid nitrogen cryotherapy	50	25	25	35.13±15.12	21	29	40	10	80.0

Abbreviations: M, male; F, female.

Figure 1 Histopathology examination before and after treatment with cantharidin cream in patients with Verruca plantaris. Patients with Verruca plantaris completed 4 weeks of treatment. (A) The histopathological examination demonstrated parakeratosis and papillomatous hyperplasia of the epidermis (hematoxylin-eosin stain, magnification 100×). (B) The histopathological examination revealed a large number of vacuolated cells in the epidermis (hematoxylin-eosin stain, magnification 400×). (C) Several neoplasms detected on the foot prior to the treatment. (D) The foot lesions were eliminated post treatment.

Table 2 Twelve-Week Follow-Up to Assess Clinical Efficacy of Verruca Plantaris Treatment

Group	Number	Sex		Mean Age (Years)	Number of Warts		Outcome (Follow-up After 4 Weeks)			P-value
		M	F		Single	Multiple	Clinically Cured	Clinical Recurrence	Clinical Efficiency (%)
Cantharidin treatment	50	28	22	34.02±16.01	20	30	43	7	86.0	0.230 (>0.05)
CO2 laser treatment	50	30	20	33.25±8.00	30	20	39	11	78.0
Liquid nitrogen cryotherapy	50	25	25	35.13±15.12	21	29	36	14	72.0

Abbreviations: M, male; F, female.