A Case of Meningitis in an Infant Due to Hypervirulent Klebsiella pneumoniae Transmission Within a Family

Figures & data

Table 1 Susceptibility Profiles of Klebsiella Pneumoniae Isolated from the Infant’s CSF, Stool Samples, and the Father’s Stool Sample

Antibiotic	Isolate From the Infant’s CSF	Isolate From the Infant’s Stool	Isolate From the Father’s Stool
	MIC (Interpretation)	MIC (Interpretation)	MIC (Interpretation)
Ampicillin	≥32(R)	≥32(R)	≥32(R)
Ampicillin/Sulbactam	≤4(S)	≤4(S)	≤4(S)
Ceftazidime	≤1(S)	≤1(S)	≤1(S)
Ceftriaxone	≤1(S)	≤1(S)	≤1(S)
Cefepime	≤1(S)	≤1(S)	≤1(S)
Imipenem	≤1(S)	≤1(S)	≤1(S)
Meropenem	≤0.25(S)	≤0.25(S)	≤0.25(S)
Amikacin	≤2(S)	≤2(S)	≤2(S)
Gentamycin	≤1(S)	≤1(S)	≤1(S)
Ciprofloxacin	≤ 0.25(S)	≤0.25(S)	≤0.25(S)
Levofloxacin	≤0.25(S)	≤0.25(S)	≤0.25(S)
Trimethoprim/Sulfametoxazole	≤20(S)	≤20(S)	≤ 20(S)

Abbreviations: MIC, minimum inhibitory concentration; S, susceptible; R, resistant.

Figure 1 The string test in an isolated colony of Klebsiella pneumoniae from the CSF on an agar plate, which showed hypermucoviscosity with a > 5-mm-long viscous filament.

Figure 2 The virulence genes of three isolates. 1–5 represent rmpA2, iucA, peg-344, iroB, and rmpA, respectively, from the father’s stool sample, and 6–10 represent rmpA2, iucA, peg-344, iroB, and rmpA, respectively, from the infant’s stool isolate. 11–15 represent rmpA2, iucA, peg-344, iroB, and rmpA, respectively, from the infant’s CSF isolate. M represents the marker.

Figure 3 The capsular types of three isolates were K2. (A and B) represent the isolate from the father’s stool. (C and D) represent the isolate from the infant’s stool. (E and F) represent the isolate from the infant’s CSF. M represents the marker.