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Infection and Drug Resistance Volume 15, 2022 - Issue
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ORIGINAL RESEARCH

Differences Between Omicron Infections and Fever Outpatients: Comparison of Clinical Manifestations and Initial Routine Hematology Indicators

Xiaojie Bi1 Department of Laboratory Medicine, Taizhou Hospital, Zhejiang University, Linhai, 317000, People’s Republic of China;2 Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of China
,
Ying Zhang2 Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of China
,
Juan Pan1 Department of Laboratory Medicine, Taizhou Hospital, Zhejiang University, Linhai, 317000, People’s Republic of China
,
Chaochao Chen2 Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of China
,
Yufen Zheng2 Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of China
,
Jing Wang2 Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of China
,
Mengyuan Chen2 Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of China
,
Kai Zhou2 Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of China
,
Tao-Hsin Tung3 Evidence-Based Medicine Center, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, 317000, People’s Republic of China
,
Bo Shen1 Department of Laboratory Medicine, Taizhou Hospital, Zhejiang University, Linhai, 317000, People’s Republic of China;2 Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of China
&
Donglian Wang1 Department of Laboratory Medicine, Taizhou Hospital, Zhejiang University, Linhai, 317000, People’s Republic of China;2 Department of Laboratory Medicine, Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University, Linhai, 317000, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 5111-5120 | Published online: 31 Aug 2022

Figures & data

Figure 1 Flow chart of the study.

Figure 1 Flow chart of the study.

Table 1 Baseline Characteristics of the Patients

Figure 2 Clinical symptoms, time of patients progression. (A) Omicron group; (B) Fever group; (C) Wild-Type group.

Figure 2 Clinical symptoms, time of patients progression. (A) Omicron group; (B) Fever group; (C) Wild-Type group.

Figure 3 Comparison of initial indexes of peripheral blood cell indices and CRP of Omicron, Fever and Wild-Type. The count of white blood cell, neutrophil, lymphocyte, monocyte, eosinophil between and CRP of Omicron, Fever and Wild-Type group were 5.0 (3.6–6.1) vs 10.1 (7.6–12.9) vs 5.4 (4.3–6.4)×109/L, 2.6 (1.8–3.9) vs 8.1 (5.9–10.9) vs 3.4 (2.5–4.7)×109/L, 1.3 (1.1–1.9) vs 1.4 (0.9–1.8) vs 1.3 (0.9–1.5)×109/L, 0.5 (0.4–0.7) vs 0.6 (0.4–0.9) vs 0.4 (0.3–0.6)×109/L, 0.06 (0.02–0.13) vs 0.05 (0.02–0.11) vs 0.01 (0.00–0.04)×109/L, 7.8 (4.3–16.3) vs 12.9 (5.0–37.9) vs 9.9 (3.8–21.5) mg/L.

Notes: The horizontal dotted line indicates the reference range of each Laboratory index (WBC: 3.9–9.5×109/L; N: 1.8–6.3×109/L; L: 1.1–3.2×109/L; M: 0.1–0.6×109/L; E: 0.02–0.52×109/L; CRP: 0–8mg/L). All data were displayed by median and interquartile range.
Abbreviations: WBC, white blood cell count; N, neutrophil count; L, lymphocyte count; M, monocyte count; E, eosinophil count; CRP, C-reactive protein.
Figure 3 Comparison of initial indexes of peripheral blood cell indices and CRP of Omicron, Fever and Wild-Type. The count of white blood cell, neutrophil, lymphocyte, monocyte, eosinophil between and CRP of Omicron, Fever and Wild-Type group were 5.0 (3.6–6.1) vs 10.1 (7.6–12.9) vs 5.4 (4.3–6.4)×109/L, 2.6 (1.8–3.9) vs 8.1 (5.9–10.9) vs 3.4 (2.5–4.7)×109/L, 1.3 (1.1–1.9) vs 1.4 (0.9–1.8) vs 1.3 (0.9–1.5)×109/L, 0.5 (0.4–0.7) vs 0.6 (0.4–0.9) vs 0.4 (0.3–0.6)×109/L, 0.06 (0.02–0.13) vs 0.05 (0.02–0.11) vs 0.01 (0.00–0.04)×109/L, 7.8 (4.3–16.3) vs 12.9 (5.0–37.9) vs 9.9 (3.8–21.5) mg/L.

Figure 4 Comparison of initial peripheral blood cell indices between Omicron and Fever in different symptom. (A) The patient presents with fever, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 5.0 (3.8–6.0) vs 5.0 (3.5–6.3) ×109/L; 2.9 (1.9–3.9) vs 2.5 (1.6–4.1).×109/L; 1.3 (1.0–1.6) vs 1.5 (1.2–1.9)×109/L; 0.5 (0.4–0.7) vs 0.4 (0.3–0.6)×109/L; 0.05 (0.01–0.09) vs 0.07 (0.04–0.15)×109/L. (B) The patient presents with cough, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 4.7 (3.4–6.0) vs 5.6 (4.3–6.1).×109/L; 2.4 (1.8–3.9) vs 3.4 (1.9–4.0)×109/L; 1.3 (1.2–1.8) vs 1.4(0.9–1.9)×109/L; 0.4 (0.3–0.6) vs: 0.6(0.4–0.8)×109/L; 0.4 (0.3–0.6) vs 0.6(0.4–0.8)×109/L. (C) The patient presents with pharyngalgia, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 4.6 (3.4–5.7) vs 5.6 (4.1–6.4).×109/L; 2.4 (1.7–3.8) vs 3.5 (1.9–4.1)×109/L; 1.3 (1.2–1.9) vs 1.3(1.0–1.7)×109/L; 0.4 (0.3–0.6) vs 0.6 (0.4–0.7)×109/L, 0.07 (0.03–0.13) vs 0.06 (0.01–0.15)×109/L. (D): The patient presents with headache, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 4.4 (3.5–5.8) vs 5.4 (4.0–6.3) ×109/L; 2.6 (1.8–3.7) vs 2.7 (1.8–4.0)×109/L; 1.2 (0.9–1.3) vs 1.4 (1.2–1.9)×109/L; 0.5 (0.4–0.6) vs 0.5 (0.3–0.7)×109/L; 0.02 (0.01–0.06) vs 0.08 (0.05–0.14)×109/L. (E) The patient presents with expectoration, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 4.6 (3.4–5.6) vs 5.4 (3.9–6.3)×109/L; 2.4 (1.7–3.9) vs 2.8 (1.9–4.0)×109/L; 1.3 (1.2–1.7) vs 1.3 (1.0–1.9)×109/L; 0.4 (0.4–0.6) vs 0.5 (0.3–0.7)×109/L; 0.05 (0.03–0.08) vs 0.07 (0.02–0.15)×109/L.

Notes: The horizontal dotted line indicates the reference range of each Laboratory index (WBC: 3.9–9.5×109/L; N: 1.8–6.3×109/L; L: 1.1–3.2×109/L; M: 0.1–0.6×109/L; E: 0.02–0.52×109/L). All data were displayed by median and interquartile range.
Abbreviations: WBC, white blood cell count; N, neutrophil count; L, lymphocyte count; M, monocyte count; E, eosinophil count; CRP, C-reactive protein.
Figure 4 Comparison of initial peripheral blood cell indices between Omicron and Fever in different symptom. (A) The patient presents with fever, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 5.0 (3.8–6.0) vs 5.0 (3.5–6.3) ×109/L; 2.9 (1.9–3.9) vs 2.5 (1.6–4.1).×109/L; 1.3 (1.0–1.6) vs 1.5 (1.2–1.9)×109/L; 0.5 (0.4–0.7) vs 0.4 (0.3–0.6)×109/L; 0.05 (0.01–0.09) vs 0.07 (0.04–0.15)×109/L. (B) The patient presents with cough, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 4.7 (3.4–6.0) vs 5.6 (4.3–6.1).×109/L; 2.4 (1.8–3.9) vs 3.4 (1.9–4.0)×109/L; 1.3 (1.2–1.8) vs 1.4(0.9–1.9)×109/L; 0.4 (0.3–0.6) vs: 0.6(0.4–0.8)×109/L; 0.4 (0.3–0.6) vs 0.6(0.4–0.8)×109/L. (C) The patient presents with pharyngalgia, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 4.6 (3.4–5.7) vs 5.6 (4.1–6.4).×109/L; 2.4 (1.7–3.8) vs 3.5 (1.9–4.1)×109/L; 1.3 (1.2–1.9) vs 1.3(1.0–1.7)×109/L; 0.4 (0.3–0.6) vs 0.6 (0.4–0.7)×109/L, 0.07 (0.03–0.13) vs 0.06 (0.01–0.15)×109/L. (D): The patient presents with headache, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 4.4 (3.5–5.8) vs 5.4 (4.0–6.3) ×109/L; 2.6 (1.8–3.7) vs 2.7 (1.8–4.0)×109/L; 1.2 (0.9–1.3) vs 1.4 (1.2–1.9)×109/L; 0.5 (0.4–0.6) vs 0.5 (0.3–0.7)×109/L; 0.02 (0.01–0.06) vs 0.08 (0.05–0.14)×109/L. (E) The patient presents with expectoration, The count of white blood cell, neutrophil, lymphocyte, monocyte and eosinophil of Omicron group were 4.6 (3.4–5.6) vs 5.4 (3.9–6.3)×109/L; 2.4 (1.7–3.9) vs 2.8 (1.9–4.0)×109/L; 1.3 (1.2–1.7) vs 1.3 (1.0–1.9)×109/L; 0.4 (0.4–0.6) vs 0.5 (0.3–0.7)×109/L; 0.05 (0.03–0.08) vs 0.07 (0.02–0.15)×109/L.

Figure 5 Comparison of the peripheral blood cell indices in of Omicron patients and Fever with variant Lung imaging. The count of white blood cell, neutrophil, lymphocyte, monocyte and Eosinophil of Omicron patients with opposite Lung imaging were 5.7 (3.5–6.3) vs 4.8 (3.8–6.0)×109/L; 3.0 (1.6–4.2) vs 2.4 (1.7–3.9) ×109/L; 1.3 (1.2–1.7) vs 1.3 (1.2–1.9)×109/L; 0.4 (0.2–0.6) vs 0.5 (30.4–0.7)×109/L; 0.06 (0.03–0.18) vs 0.07 (0.01–0.16)×109/L.

Notes:The horizontal dotted line indicates the reference range of each Laboratory index (WBC: 3.9–9.5×109/L; N: 1.8–6.3×109/L; L: 1.1–3.2×109/L; M: 0.1–0.6×109/L; E: 0.02–0.52×109/L).
Abbreviations: URTI, upper respiratory tract infections; ILI, Influenza-like Illness; NAAT, Nucleic Acid Amplification Test; BMI, Body Mass Index; IQR, interquartile range; SD, standard deviation; n, number; WBC, white blood cell count; N, neutrophil count; L, lymphocyte count; M, monocyte count; E, eosinophil count; CRP, C-reactive protein.
Figure 5 Comparison of the peripheral blood cell indices in of Omicron patients and Fever with variant Lung imaging. The count of white blood cell, neutrophil, lymphocyte, monocyte and Eosinophil of Omicron patients with opposite Lung imaging were 5.7 (3.5–6.3) vs 4.8 (3.8–6.0)×109/L; 3.0 (1.6–4.2) vs 2.4 (1.7–3.9) ×109/L; 1.3 (1.2–1.7) vs 1.3 (1.2–1.9)×109/L; 0.4 (0.2–0.6) vs 0.5 (30.4–0.7)×109/L; 0.06 (0.03–0.18) vs 0.07 (0.01–0.16)×109/L.

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