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Infection and Drug Resistance Volume 15, 2022 - Issue
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SHORT REPORT

Late-Onset Sepsis in a Premature Infant Mediated by Breast Milk: Mother-to-Infant Transmission of Group B Streptococcus Detected by Whole-Genome Sequencing

Aiyun Li1 Department of Clinical Medicine, The Women’s Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
,
Ming Fang2 Institute of Infection Disease Control, Shandong Center for Disease Control and Prevention, Jinan, People’s Republic of ChinaView further author information
,
Dongjie Hao1 Department of Clinical Medicine, The Women’s Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
,
Qiaoai Wu1 Department of Clinical Medicine, The Women’s Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
,
Yaqi Qian1 Department of Clinical Medicine, The Women’s Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
,
Hao Xu3 State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China;4 Department of Structure and Morphology, Jinan Microecological Biomedicine Shandong Laboratory, Jinan, People’s Republic of ChinaCorrespondence[email protected] [email protected]
View further author information
&
Bo Zhu1 Department of Clinical Medicine, The Women’s Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of ChinaView further author information
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Pages 5345-5352 | Received 15 Jul 2022, Accepted 07 Sep 2022, Published online: 09 Sep 2022

Figures & data

Figure 1 The critical nodes in the diagnosis and treatment process.

Abbreviations: GBS, Group B streptococcal; WGS, whole-genome sequencing; UU, ureaplasma urealyticum.
Figure 1 The critical nodes in the diagnosis and treatment process.

Figure 2 Phylogenetic analysis of GBS showed that all three isolates are highly related. The GBS strain isolated from the infant’s bloodstream (2106075219GBS) was 100% homologous from the GBS strain isolated from the mother’s breast milk (2106093122GBS), which differed from the GBS strain isolated from the mother’s cervical secretion (2105132239GBS).

Figure 2 Phylogenetic analysis of GBS showed that all three isolates are highly related. The GBS strain isolated from the infant’s bloodstream (2106075219GBS) was 100% homologous from the GBS strain isolated from the mother’s breast milk (2106093122GBS), which differed from the GBS strain isolated from the mother’s cervical secretion (2105132239GBS).

Figure 3 Core-genome phylogeny and virulence factors of GBS isolates from the NCBI genome database and the three isolates from this study. Scale bars represent the number of substitutions per site. The virulence gene distribution of GBS isolates is presented on the right. Isolates identified in this study are shown in red.

Figure 3 Core-genome phylogeny and virulence factors of GBS isolates from the NCBI genome database and the three isolates from this study. Scale bars represent the number of substitutions per site. The virulence gene distribution of GBS isolates is presented on the right. Isolates identified in this study are shown in red.

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