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ORIGINAL RESEARCH

Effect of Colistin, Fosfomycin and Meropenem/Vaborbactam on Carbapenem-Resistant Enterobacterales in Egypt: A Cross-Sectional Study

, ORCID Icon, & ORCID Icon
Pages 6203-6214 | Received 08 Aug 2022, Accepted 14 Oct 2022, Published online: 27 Oct 2022

Figures & data

Table 1 Primers’ Sequences and Amplicons’ Size Used in PCR for Carbapenemase, Integrons and fosA Genes Detection

Table 2 Antimicrobial Susceptibility Pattern of the Uropathogenic CRE Strains

Figure 1 Meropenem/vaborbactam and fosfomycin susceptibility testing using the MIC Test Strip according to CLSI guidelines. (A) Meropenem/vaborbactam susceptible strain (MIC = 0.032 µg/mL), (B) meropenem/vaborbactam resistant strain (MIC > 256 µg/mL), (C) fosfomycin susceptible strain (MIC = 0.25 µg/mL) and (D) fosfomycin resistant strain (MIC > 256 µg/mL).

Figure 1 Meropenem/vaborbactam and fosfomycin susceptibility testing using the MIC Test Strip according to CLSI guidelines. (A) Meropenem/vaborbactam susceptible strain (MIC = 0.032 µg/mL), (B) meropenem/vaborbactam resistant strain (MIC > 256 µg/mL), (C) fosfomycin susceptible strain (MIC = 0.25 µg/mL) and (D) fosfomycin resistant strain (MIC > 256 µg/mL).

Table 3 Detection of Carbapenemase and Integrons Genes by PCR and the Sensitivity of CRE Isolates to Meropenem/Vaborbactam

Table 4 Performance of the Modified Carbapenem Inactivation Method (mCIM) and EDTA-Modified Carbapenem Inactivation Method (eCIM) in Screening of Carbapenemase Activity of Carbapenem Resistant Isolates

Table 5 Antibiotic Resistance Pattern and the Distribution of Integron and fosA Genes Among Carbapenemase Producing Enterobacterales (CPE) and Non-CPE Isolates