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Infection and Drug Resistance Volume 15, 2022 - Issue
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ORIGINAL RESEARCH

Central Nervous System Toxicity of Voriconazole: Risk Factors and Threshold – A Retrospective Cohort Study

Luting YangDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Chuhui WangDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-7328-9851View further author information
ORCID Icon,
Yijing ZhangDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Quanfang WangDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Yulan QiuDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Sihan LiDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Bo YangDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Qian DuDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Jiaojiao ChenDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Mengmeng TengDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Taotao WangDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaView further author information
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Yalin DongDepartment of Pharmacy, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of ChinaCorrespondence[email protected] [email protected]
ORCID Iconhttps://orcid.org/0000-0001-5619-0788View further author information
ORCID Icon show all
Pages 7475-7484 | Received 24 Sep 2022, Accepted 02 Dec 2022, Published online: 16 Dec 2022

Figures & data

Table 1 Demographic and Clinical Characteristics of Patients with and without CNS Neurotoxicity

Figure 1 The Cmin distribution of voriconazole in whole and different concentrations.

Figure 1 The Cmin distribution of voriconazole in whole and different concentrations.

Figure 2 Distribution of voriconazole Cmin in patients with and without CNS toxicity. ***P<0.001.

Figure 2 Distribution of voriconazole Cmin in patients with and without CNS toxicity. ***P<0.001.

Table 2 Univariate and Multivariate Logistic Regression Analysis to Identify Risk Factors

Figure 3 Categorical regression tree model predicting CNS toxicity of voriconazole (AE refers to adverse events).

Figure 3 Categorical regression tree model predicting CNS toxicity of voriconazole (AE refers to adverse events).

Table 3 Analysis of CNS Toxicity in CYP2C19 Subgroups in Patients with Voriconazole

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