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Infection and Drug Resistance Volume 15, 2022 - Issue
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ORIGINAL RESEARCH

Clinical Characteristics, Microbiology, and Risk Factors for Mortality of Pre-Engraftment and Post-Engraftment Bloodstream Infection in Hematopoietic Stem Cell Transplantation Recipients

Weihao Chen1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Yanmin Zhao1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Yi Luo1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Jian Yu1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Huarui Fu1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Xiaoyu Lai1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Lizhen Liu1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Yishan Ye1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Jingsong He1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Jie Sun1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Weiyan Zheng1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Yi Zhao1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Guoqing Wei1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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Zhen Cai1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
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He Huang1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaView further author information
&
Jimin Shi1 Bone Marrow Transplantation Center, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, People’s Republic of China;2 Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, 311121, People’s Republic of China;3 Institute of Hematology, Zhejiang University, Hangzhou, People’s Republic of China;4 Zhejiang Province Engineering Laboratory for Stem Cell and Immunity Therapy, Hangzhou, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 6893-6905 | Received 15 Oct 2022, Accepted 16 Nov 2022, Published online: 28 Nov 2022

Figures & data

Figure 1 Diagram of patients’ grouping process of BSI after HSCT.

Figure 1 Diagram of patients’ grouping process of BSI after HSCT.

Table 1 Patient Characteristics

Table 2 Clinical Characteristics of BSI

Table 3 Microbiological Classification and All-Cause Mortality Rate Caused by Pathogens of BSI

Figure 2 Distribution of pathogenic organisms in different periods.

Figure 2 Distribution of pathogenic organisms in different periods.

Figure 3 OS curve for 3 months after pre-engraftment BSI vs post-engraftment BSI (p=0.005).

Figure 3 OS curve for 3 months after pre-engraftment BSI vs post-engraftment BSI (p=0.005).

Table 4 Univariate Analyses of Risk Factors for All-Cause Mortality at 3 Months After Bloodstream Infection

Table 5 Multivariate Analyses of Risk Factors for All-Cause Mortality at 3 Months After Bloodstream Infection

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