Genetic and Phenotypic Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolates from a Tertiary Hospital in Beijing

Figures & data

Table 1 Antimicrobial Susceptibility of K. pneumoniae Isolates

Drug Classes	Antimicrobials	Resistant n (%)	Intermediate n (%)	Susceptible n (%)
β-lactams	Ampicillin	24 (100.00)	0 (0.00)	0 (0.00)
	Amoxicillin/Clavulanate	24 (100.00)	0 (0.00)	0 (0.00)
	Ampicillin/Sulbactam	24 (100.00)	0 (0.00)	0 (0.00)
	Piperacillin/Tazobactam	24 (100.00)	0 (0.00)	0 (0.00)
	Cefazolin	24 (100.00)	0 (0.00)	0 (0.00)
	Cefepime	24 (100.00)	0 (0.00)	0 (0.00)
	Cefotaxime	24 (100.00)	0 (0.00)	0 (0.00)
	Ceftazidime	24 (100.00)	0 (0.00)	0 (0.00)
Carbapenems	Meropenem	24 (100.00)	0 (0.00)	0 (0.00)
	Imipenem	22 (91.67.00)	2 (8.33)	0 (0.00)
Aminoglycosides	Gentamicin	20 (83.33)	1 (4.17)	3 (12.50)
	Amikacin	8 (33.33)	0 (0.00)	16 (66.67)
Fluroquinolones	Ciprofloxacin	22 (91.67)	1 (4.17)	1 (4.16)
	Moxifloxacin	22 (91.67)	1 (4.17)	1 (4.16)
	Levofloxacin	22 (91.67)	2 (8.33)	0 (0.00)
Sulfonamides	Trimethoprim/Sulfamethoxazole	17 (70.83)	0 (0.00)	7 (29.17)
Tetracyclines	Tetracycline	18 (75.00)	0 (0.00)	6 (25.00)
Monocyclic β- lactams	Aztreonam	22 (91.67)	2 (8.33)	0 (0.00)

Figure 1 Distribution of antibiotic resistance genes, plasmids and STs of all strains. Colors represent different clades. Red represents subclade 1, blue represents subclade 2, and purple represents subclade 3. The antique white squares represent corresponding ARGs or replicons.

Figure 2 The genome circle map of plasmids pBJ1913-TEM (A) and pBJ1913-NDM5 (B) carried by strain BJ19-0013. The blue color in the outer circle represents the plasmid replicon protein, the red color represents the drug resistance gene region, and the Orange color represents the protein coding region. The inner-circle indicates the positive and negative GC skew of the plasmid in green and purple, respectively.