Candida haemulonii Complex and Candida auris: Biology, Virulence Factors, Immune Response, and Multidrug Resistance

Figures & data

Table 1 Putative Virulence Factors in Candida auris, C. haemulonii, and C. duobushaemulonii

Virulence Factor	C. albicans	C. auris	C. haemulonii	C. duobushaemulonii	E- value*	Similarity (%)*
Adhesins	Als1	CJI96_0005138	CXQ85_004547	CXQ87_001667	5e^−45	52
	Als5	CJJ09_005316	CXQ85_004547	CXQ87_004268	1e^−34	49
	Eap1	No found	No found	No found	-	-
	Ecm33	CJI96_0003481	CXQ85_001305	CXQ87_002344	8e^−109	74
	Hwp1	No found	No found	No found	-	-
	Iff4	FDK38_004751	CA3LBN_002465	CXQ87_001664	3e^−35	54
	Int1	CJI97_004446	CXQ85_004340	CXQ87_001341	0	59
	Mp65	CJI97_003871	CA3LBN_003990	CXQ87_004408	7e^−128	82
	Mnt1	CJI97_002568	CA3LBN_000314	CXQ87_000344	0	79
Biofilm formation	Bcr1	CJI97_004038	CXQ85_004690	CXQ87_002954	4e^−38	89
	Brg1	FDK38_005190	FT662_01339	CXQ87_004952	1e^−46	86
	Efg1	QG37_02326	CXQ85_002192	CXQ87_000637	8e^−82	96
	Hsp90	CJI97_005002	CXQ85_001622	CXQ87_003642	0	95
	Ndt80	QG37_08107	CXQ85_000348	CXQ87_003781	4e^−104	64
	Rob1	CJI96_0002486	CXQ85_004697	CXQ87_001650	4e^−18	59
	Csr1	QG37_01438	FT662_04426	CXQ87_003974	1e^−137	54
Dimorphism	Cph1	QG37_02170	CA3LBN_000777	CXQ87_000890	5e^−113	64
	Hgc1	CJI96_0003736	CXQ85_001596	CXQ87_003669	8e^−98	65
	Nrg1	CJI96_0004799	CA3LBN_003361	CXQ87_004169	6e^−32	84
	Tup1	CJI96_0003109	CXQ85_002914	CXQ87_003349	0	88
Hydrolytic enzymes	Lip5,6	CJI97_004237	CXQ85_004470 CXQ85_005044	CXQ87_004175 CXQ87_004891	1e^−131	66
	Lip7	QG37_04164	CA3LBN_003355	CXQ87_004175	6e^−82	57
	Lip8	CJJ07_002584	CXQ85_005044	CXQ87_004175	6e^−120	64
	Sap1-5	CJI97_001086 QG37_06522 FDK38_003693	CA3LBN_003236	CXQ87_003599	6e^−65	50
	Plb1	CJI96_0001982	CA3LBN_002387	CXQ87_001754	7e^−44	64
	Plb2	FDK38_001316	CXQ85_003530	CXQ87_001754	0	67
	Plb3	B9J08_003621	CA3LBN_002270	CXQ87_001881	0	73
Immune evasion	Hgt1	CJI97_005618	CA3LBN_003269	CXQ87_004697	0	81
	Msb2	CJJ09_002134	CXQ85_000170	CXQ87_002736	9e^−61	59
	Pra1	CJI96_0000822	CXQ85_002340	CXQ87_000786	4e^−82	65
Thermotolerance	Hsp60	CA7LBN_000129	CXQ85_004696	CXQ87_001649	0	96
	Hsp104	CJJ07_002319	CA3LBN_001741	CXQ87_002478	0	94
	Ssa1/Hsp70	FDK38_001195	CXQ85_001344	CXQ87_001126	0	94

Notes: *A BlastP analysis was performed using the database of The National Center for Biotechnology (https://www.ncbi.nlm.nih.gov/) using the C. albicans proteins as a query.