Emergence of OXA-484-Producing Klebsiella variicola in China

Haoyu Ge1 Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China;2 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

Jie Qiao1 Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China;2 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

Hao Xu2 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

Ruishan Liu2 Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

Junhui Zhao3 School of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China

Ruyan Chen1 Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China

Chenyu Li1 Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China

Mantao Chen4 Department of Neurosurgery, the First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

Xiaobing Guo1 Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of ChinaCorrespondence[email protected]

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Table 1 Susceptibility of K. variicola 4717

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Figure 1 Biofilm formation analysis of K. variicola 4717. Ac, the negative control.

Figure 2 Genomic analyses of plasmid p4717-OXA-484. (A) Comparative analysis of plasmids p4717-OXA-484 with pLB_OXA-181_PT109 (no. CP041033), pSECR18-2374D (no. CP041931) and pKS22 (no. KT005457). (B) Comparison of genes surrounding bla_OXA-484 on p4717-OXA-484, pLB_OXA-181_PT109 (no. CP041033), pSECR18-2374D (no. CP041931) and pKS22 (no. KT005457). Open reading frames (ORFs) are shown as arrows and indicated according to their putative functions. Red indicates antimicrobial resistance genes, light blue indicates genes related to mobile elements, and the Orange represents other functional genes. Regions with a high degree of homology are indicated by blue shading.

Figure 3 Alignment of two companion plasmids p4717_1 and p4717_2. (A) The p4717_1 showed high similarity with three known plasmids, namely pKP91 (no. CP000966), p15WZ-82_res (no. CP032357) and pM142-3 (no. CP063868). (B) The p4717_2 was similar with pBSI138_P3 (no. MT269850), plasmid p4_1_2.1 (no. CP023840) and plasmid pDA33140-112 (no. CP029583).

Emergence of OXA-484-Producing Klebsiella variicola in China

Table 1 Susceptibility of K. variicola 4717

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Emergence of OXA-484-Producing Klebsiella variicola in China

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Table 1 Susceptibility of K. variicola 4717

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