Assessment of Effective Anti-TB Regimens and Adverse Outcomes Related Risk Factors in the Elderly and Senile-Aged TB Patients

Figures & data

Figure 1 Diagnosis and Treatment Flow Chart of Pulmonary Tuberculosis Patients.

Figure 2 Flow Chart of Case Screening in this Study.

Table 1 Treatment Outcomes of 1191 Senile-Aged Patients with TB from 2011 to 2021

Year	Total Number	Cured		Treatment Completion		Treatment Failure		Lost to Follow-Up		Death
		n	%	n	%	n	%	n	%	n	%
2011	90	32	35.56	46	51.11	0	0	8	8.89	4	0.44
2012	87	35	40.23	30	34.48	0	0	17	19.54	5	0.57
2013	68	36	52.94	29	45.65	1	1.47	2	2.91	0	0
2014	72	37	51.39	32	44.44	2	2.78	1	1.39	0	0
2015	75	38	50.67	35	46.67	0	0	2	2.67	0	0
2016	86	42	48.84	36	41.86	0	0	5	5.81	3	3.49
2017	96	50	52.08	31	32.29	1	1.04	5	5.21	9	9.38
2018	102	58	56.86	29	28.43	1	0.98	7	6.86	7	6.86
2019	152	89	58.55	42	27.63	2	1.32	10	6.58	9	5.92
2020	178	113	63.48	39	21.91	2	1.12	6	3.37	18	10.11
2021	185	71	38.38	60	32.43	2	1.08	31	16.76	21	11.35
Total	1191	601	50.46	409	34.34	11	0.92	94	7.89	76	6.38

Table 2 Single-Factor Analysis of Influencing Factors of Treatment Outcome for TB in Senile-Aged Patients

Item	Treatment Success (n=1010)		Adverse Outcome (n=181)		χ^2-value	P-value
	Number	Proportion (%)	Number	Proportion (%)
Gender					0.751	0.386
Male	768	84.30	143	15.70
Female	242	86.43	38	13.57
Age (year)					36.615	<0.001*
≥ 80	200	73.26	73	26.74
< 80	810	88.24	108	11.76
Registered residence					0.094	0.759
Non-local	202	84.17	38	15.83
Local	808	84.96	143	15.04
Occupation					0.413	0.520
Non-farmers	154	83.24	31	16.76
Farmers	856	85.09	150	14.91
Initial treatment/ retreatment					0.855	0.355
Retreatment	105	82.03	23	17.97
Initial treatment	905	85.14	158	14.86
Diagnosis					0.868	0.351
Etiologically positive	673	84.13	127	15.88
Etiologically negative	337	86.19	54	13.81
Diabetes					2.734	0.098
Yes	89	79.46	23	20.54
No	921	85.36	158	14.64
Lesion range ≥ 3 lung fields					8.692	0.003*
No	310	89.60	36	10.40
Yes	700	82.84	145	17.16
Radiographic lesion improved after 2 months of treatment					13.979	<0.001*
Yes	915	86.16	147	13.84
No	95	73.64	34	26.36
Sputum bacteriological result turned negative after 2 months of treatment					6.041	0.014*
Yes	957	85.45	163	14.55
No	53	74.65	18	25.35
Delayed treatment					0.276	0.600
Yes	777	85.10	136	14.90
No	233	83.81	45	16.19
Use of standardized treatment plan					31.845	<0.001*
Yes	570	90.33	61	9.67
No	440	78.57	120	21.43
Use of FDC					5.473	0.019*
Yes	190	90.05	21	9.95
No	820	83.67	160	16.33
Isoniazid resistance					0.452	0.798
Yes	25	83.33	5	16.67
No	301	83.84	58	16.16
Unspecified	684	85.29	118	14.71
Involvement of TCM					5.501	0.019*
Yes	876	85.80	145	14.20
No	134	78.82	36	21.18
Occur ADIH					0.818	0.366
Yes	126	82.35	27	17.65
No	884	85.16	154	14.84

Note: *P<0.05 has a statistic significance.

Table 3 Multi-Factor Logistic Regression Analysis Results of Influencing Factors of Treatment Outcome for TB in Senile-Aged Patients

Variable	Reference Group	β	S.E.	Wald	P	OR	95% CI
Age (year)
≥80	<80	0.782	0.187	17.574	<0.001*	2.186	1.517–3.152
Lesion range ≥ 3 lung fields
Yes	No	−0.891	0.233	14.651	<0.001*	0.410	0.260–0.648
Radiographic lesion improved after 2 months of treatment
No	Yes	0.717	0.231	9.610	0.002*	2.048	1.302–3.223
Sputum bacteriological result turned negative after 2 months of treatment
No	Yes	0.794	0.301	6.972	0.008*	2.213	1.227–3.990
Use of standardized treatment plan
No	Yes	0.740	0.206	12.855	<0.001*	2.095	1.398–3.139
Use of FDC
No	Yes	−0.043	0.290	0.022	0.883	0.958	0.543–1.690
Involvement of TCM
No	Yes	0.951	0.249	14.597	<0.001*	2.589	1.589–4.216

Notes:*P<0.05 has a statistic significance; β: the “partial regression coefficient”; S.E.: the standard error of partial regression coefficient β; Wald: the Wald statistic used to test whether the population partial regression coefficient β has statistical significance with 0; OR: odds ratio, dominance ratio or ratio ratio which is the inverse natural logarithm of partial regression coefficient, ie exp (β).