REGECEL (an Oxidized Regenerated Cellulose) Provides Superior Bioactivity Effect on Microorganisms

Figures & data

Table 1 Inhibition Percentages and CFUs for ORC. The Table Presents the Inhibition and CFUs (Colony-Forming Units) for 33 Bacterial Strains, as Well as C. Albicans. (A) CTL; (B) ORCK; (C) ORCS; (D) ORCF; (E) ORCN

Organisms	CTL1	CTL2	CTL3	AVG (CFU/mL)		Growth %	Inhibition %
(A)
Pseudomonas aeruginosa BAA1744	162	186	182	176.67		100	0
Enterobacter cloacae 13047	202	235	213	216.67		100	0
Enterococcus faecalis 51299	226	227	261	238.00		100	0
Pseudomonas aeruginosa 9027	310	286	328	308.00		100	0
K.pneumoniae 13883	133	131	150	138.00		100	0
Staph. Saprophyticus 49907	89	94	85	89.33		100	0
Micrococcus luteus 49732	16	15	14	15.00		100	0
Corynebacterium striatum BAA1293	122	155	164	147.00		100	0
Pseudomonas aeruginosa 27853	309	257	266	277.33		100	0
E.coli 35218	348	308	327	327.67		100	0
Salmonella enteritidis 13076	306	293	245	281.33		100	0
Methicillin-resistant Staphylococcus aureus 43300	308	285	299	297.33		100	0
Streptococcus pneumoniae 49136	92	98	85	91.67		100	0
Haemophilus influenzae 10211	252	292	255	266.33		100	0
Enterococcus faecalis 25212	235	244	0	239.50		100	0
Streptococcus agalactiae B12386	189	173	156	172.67		100	0
Haemophilus influenzae 9007	313	309	293	305.00		100	0
Candida albicans 10231	9	11	9	9.67		100	0
Moraxella catarrhalis 8176	250	250	250	250.00		100	0
Neisseria meningitidis 13090	227	238	216	227.00		100	0
Moraxella catarrhalis 25238	205	258	244	235.67		100	0
Proteus vulgaris 8427	272	246	261	259.67		100	0
Staph. aureus 25923	161	141	145	149.00		100	0
E.coli 25922	163	164	172	166.33		100	0
Streptococcus pyogenes A 19615	219	223	215	219.00		100	0
Shigella. Sonnei 25931	237	230	246	237.67		100	0
Enterobacter aerogenes 13048	328	303	321	317.33		100	0
K.pneumoniae 700603	295	248	255	266.00		100	0
Staph. aureus 29213	211	198	204	204.33		100	0
Staph. Epidermidis 12228	83	72	88	81.00		100	0
Clostridium perfringens 13124	90	76	83	83.00		100	0
Penicillin resistant Strep. Pneumoniae	126	121	123	123.33		100	0
Vancomycin resistant enterococcus	213	201	218	210.67		100	0
(B)
Pseudomonas aeruginosa BAA1744	2	2	2	2.00		1.13	98.87
Enterobacter cloacae 13047	105	101	86	97.33		44.92	55.08
Enterococcus faecalis 51299	74	84	72	76.67		32.21	67.79
Pseudomonas aeruginosa 9027	6	0	10	5.33		1.73	98.27
K.pneumoniae 13883	67	53	60	60.00		43.48	56.52
Staph. Saprophyticus 49907	56	24	46	42.00		47.01	52.99
Micrococcus luteus 49732	1	0	0	0.33		2.22	97.78
Corynebacterium striatum BAA1293	0	0	0	0.00		0.00	100.00
Pseudomonas aeruginosa 27853	4	5	2	3.67		1.32	98.68
E.coli 35218	192	197	0	129.67		39.57	60.43
Salmonella enteritidis 13076	54	61	35	50.00		17.77	82.23
Methicillin-resistant Staphylococcus aureus 43300	136	142	165	147.67		49.66	50.34
Streptococcus pneumoniae 49136	0	0	0	0.00		0.00	100.00
Haemophilus influenzae 10211	0	0	0	0.00		0.00	100.00
Enterococcus faecalis 25212	115	134	129	126.00		52.61	47.39
Streptococcus agalactiae B12386	4	1	3	2.67		1.54	98.46
Haemophilus influenzae 9007	0	0	0	0.00		0.00	100.00
Candida albicans 10231	3	6	5	4.67		48.28	51.72
Moraxella catarrhalis 8176	0	0	0	0.00		0.00	100.00
Neisseria meningitidis 13090	0	0	0	0.00		0.00	100.00
Moraxella catarrhalis 25238	33	38	22	31.00		13.15	86.85
Proteus vulgaris 8427	126	123	129	126.00		48.52	51.48
Staph. aureus 25923	19	40	24	27.67		18.57	81.43
E. coli 25922	85	89	34	69.33		41.68	58.32
Streptococcus pyogenes A 19615	0	0	0	0.00		0.00	100.00
Shigella. Sonnei 25931	37	40	35	37.33		15.71	84.29
Enterobacter aerogenes 13048	133	145	149	142.33		44.85	55.15
K.pneumoniae 700603	137	127	137	133.67		50.25	49.75
Staph. aureus 29213	73	80	99	84.00		41.11	58.89
Staph. Epidermidis 12228	52	35	58	48.33		59.67	40.33
Clostridium perfringens 13124	24	28	12	21.33		25.70	74.30
Penicillin resistant Strep. Pneumoniae	0	0	0	0.00		0.00	100.00
Vancomycin resistant enterococcus	86	93	98	92.33		43.83	56.17
(C)
Pseudomonas aeruginosa BAA1744	5	1	0		2.00	1.13	98.87
Enterobacter cloacae 13047	167	111	93		123.67	57.08	42.92
Enterococcus faecalis 51299	66	86	63		71.67	30.11	69.89
Pseudomonas aeruginosa 9027	0	0	0		0.00	0.00	100.00
K.pneumoniae 13883	48	66	74		62.67	45.41	54.59
Staph. Saprophyticus 49907	70	55	53		59.33	66.42	33.58
Micrococcus luteus 49732	0	0	0		0.00	0.00	100.00
Corynebacterium striatum BAA1293	0	0	0		0.00	0.00	100.00
Pseudomonas aeruginosa 27853	3	3	0		2.00	0.72	99.28
E.coli 35218	40	47	33		40.00	12.21	87.79
Salmonella enteritidis 13076	9	6	9		8.00	2.84	97.16
Methicillin-resistant Staphylococcus aureus 43300	44	74	55		57.67	19.39	80.61
Streptococcus pneumoniae 49136	0	0	0		0.00	0.00	100.00
Haemophilus influenzae 10211	0	0	0		0.00	0.00	100.00
Enterococcus faecalis 25212	195	205	0		200.00	83.51	16.49
Streptococcus agalactiae B12386	0	0	0		0.00	0.00	100.00
Haemophilus influenzae 9007	0	0	0		0.00	0.00	100.00
Candida albicans 10231	1	3	0		1.33	13.79	86.21
Moraxella catarrhalis 8176	0	0	0		0.00	0.00	100.00
Neisseria meningitidis 13090	0	0	0		0.00	0.00	100.00
Moraxella catarrhalis 25238	72	54	74		66.67	28.29	71.71
Proteus vulgaris 8427	156	152	131		146.33	56.35	43.65
Staph. aureus 25923	7	18	22		15.67	10.51	89.49
E.coli 25922	49	57	70		58.67	35.27	64.73
Streptococcus pyogenes A 19615	2	2	1		1.67	0.76	99.24
Shigella. Sonnei 25931	109	115	105		109.67	46.14	53.86
Enterobacter aerogenes 13048	97	86	88		90.33	28.47	71.53
K.pneumoniae 700603	84	100	94		92.67	34.84	65.16
Staph. aureus 29213	31	47	39		39.00	19.09	80.91
Staph. Epidermidis 12228	18	17	12		15.67	19.34	80.66
Clostridium perfringens 13124	0	0	0		0.00	0.00	100.00
Penicillin resistant Strep. Pneumoniae	0	0	0		0.00	0.00	100.00
Vancomycin resistant enterococcus	112	78	135		108.33	51.42	48.58
(D)
Pseudomonas aeruginosa BAA1744	2	1	0		1.00	0.57	99.43
Enterobacter cloacae 13047	110	125	120		118.33	54.62	45.38
Enterococcus faecalis 51299	78	51	87		72.00	30.25	69.75
Pseudomonas aeruginosa 9027	5	0	4		3.00	0.97	99.03
K.pneumoniae 13883	122	114	87		107.67	78.02	21.98
Staph. Saprophyticus 49907	7	7	1		5.00	5.60	94.40
Micrococcus luteus 49732	0	0	0		0.00	0.00	100.00
Corynebacterium striatum BAA1293	0	0	0		0.00	0.00	100.00
Pseudomonas aeruginosa 27853	2	0	0		0.67	0.24	99.76
E.coli 35218	185	186	136		169.00	51.58	48.42
Salmonella enteritidis 13076	7	1	7		5.00	1.78	98.22
Methicillin-resistant Staphylococcus aureus 43300	12	7	17		12.00	4.04	95.96
Streptococcus pneumoniae 49136	0	0	0		0.00	0.00	100.00
Haemophilus influenzae 10211	0	0	0		0.00	0.00	100.00
Enterococcus faecalis 25212	92	179	217		162.67	67.92	32.08
Streptococcus agalactiae B12386	30	12	25		22.33	12.93	87.07
Haemophilus influenzae 9007	0	0	0		0.00	0.00	100.00
Candida albicans 10231	1	2	0		1.00	10.34	89.66
Moraxella catarrhalis 8176	0	0	0		0.00	0.00	100.00
Neisseria meningitidis 13090	0	0	0		0.00	0.00	100.00
Moraxella catarrhalis 25238	7	3	9		6.33	2.69	97.31
Proteus vulgaris 8427	124	114	0		119.00	45.83	54.17
Staph. aureus 25923	16	2	0		6.00	4.03	95.97
E.coli 25922	48	15	24		29.00	17.43	82.57
Streptococcus pyogenes A 19615	0	0	0		0.00	0.00	100.00
Shigella. Sonnei 25931	143	154	162		153.00	64.38	35.62
Enterobacter aerogenes 13048	131	143	141		138.33	43.59	56.41
K.pneumoniae 700603	129	181	185		165.00	62.03	37.97
Staph. aureus 29213	50	73	85		69.33	33.93	66.07
Staph. Epidermidis 12228	23	37	25		28.33	34.98	65.02
Clostridium perfringens 13124	0	0	0		0.00	0.00	100.00
Penicillin resistant Strep. Pneumoniae	0	0	0		0.00	0.00	100.00
Vancomycin resistant enterococcus	37	32	37		35.33	16.77	83.23
(E)
Pseudomonas aeruginosa BAA1744	14	12	18		14.67	8.30	91.70
Enterobacter cloacae 13047	203	165	179		182.33	84.15	15.85
Enterococcus faecalis 51299	58	51	45		51.33	21.57	78.43
Pseudomonas aeruginosa 9027	83	117	99		99.67	32.36	67.64
K.pneumoniae 13883	92	85	70		82.33	59.66	40.34
Staph. Saprophyticus 49907	5	3	3		3.67	4.10	95.90
Micrococcus luteus 49732	3	0	1		1.33	8.89	91.11
Corynebacterium striatum BAA1293	0	0	0		0.00	0.00	100.00
Pseudomonas aeruginosa 27853	0	0	0		0.00	0.00	100.00
E.coli 35218	35	23	17		25.00	7.63	92.37
Salmonella enteritidis 13076	5	4	1		3.33	1.18	98.82
Methicillin-resistant Staphylococcus aureus 43300	5	11	11		9.00	3.03	96.97
Streptococcus pneumoniae 49136	0	0	0		0.00	0.00	100.00
Haemophilus influenzae 10211	0	0	0		0.00	0.00	100.00
Enterococcus faecalis 25212	260	214	0		158.00	65.97	34.03
Streptococcus agalactiae B12386	0	0	0		0.00	0.00	100.00
Haemophilus influenzae 9007	0	0	0		0.00	0.00	100.00
Candida albicans 10231	4	4	0		2.67	27.59	72.41
Moraxella catarrhalis 8176	0	0	0		0.00	0.00	100.00
Neisseria meningitidis 13090	0	0	0		0.00	0.00	100.00
Moraxella catarrhalis 25238	0	0	0		0.00	0.00	100.00
Proteus vulgaris 8427	107	105	119		110.33	42.49	57.51
Staph. aureus 25923	7	2	4		4.33	2.91	97.09
E.coli 25922	65	49	56		56.67	34.07	65.93
Streptococcus pyogenes A 19615	0	0	0		0.00	0.00	100.00
Shigella. Sonnei 25931	4	1	1		2.00	0.84	99.16
Enterobacter aerogenes 13048	92	107	84		94.33	29.73	70.27
K.pneumoniae 700603	126	117	116		119.67	44.99	55.01
Staph. aureus 29213	27	33	41		33.67	16.48	83.52
Staph. Epidermidis 12228	25	20	23		22.67	27.98	72.02
Clostridium perfringens 13124	0	0	0		0.00	0.00	100.00
Penicillin resistant Strep. Pneumoniae	0	0	0		0.00	0.00	100.00
Vancomycin resistant enterococcus	73	59	80		70.67	33.54	66.46

Abbreviations: CTL, control; ORCK, knit; ORCS, Standard; ORCF, Fibril; ORCN, Non-woven.

Figure 1 Effects of ORC exposure on 12 strains. Quantitative graphs of 12 bacterial strains exposed to ORC agents including standard, knit, fibril, and non-woven. The controls were non-treated strains. The significance (P value) was referred as * ≤ 0.05, ** ≤ 0.01, and *** ≤ 0.001.

Figure 2 Effects of ORC exposure on 12 strains. Quantitative graphs of 12 bacterial strains exposed to ORC agents including standard, knit, fibril, and non-woven. The controls were non-treated strains. The significance (P value) was referred as ** ≤ 0.01, *** ≤ 0.001.

Figure 3 Effects of ORC exposure on 5 strains. Quantitative graphs of 5 bacterial strains exposed to ORC agents including standard, knit, fibril, and non-woven. The controls were non-treated strains. The significance (P value) was referred as * ≤ 0.05, ** ≤ 0.01, and *** ≤ 0.001.

Figure 4 Effects of ORC exposure on four pathogens. Quantitative graphs of four major pathogens (MRSA, VRE, PRSP, and C. albicans) exposed to ORC agents including standard, knit, fibril, and non-woven. The controls were non-treated pathogens. The significance (P value) was referred as * ≤ 0.05, ** ≤ 0.01, and *** ≤ 0.001.