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Infection and Drug Resistance Volume 17, 2024 - Issue
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ORIGINAL RESEARCH

Study of the Epidemiological and Mechanistic Differences Between Carbapenem-Resistant Klebsiella pneumoniae Infections in Children and Adults

Jiajia Zhou1 The Huai’an Maternity and Child Clinical College of Xuzhou Medical University, Huai’an, People’s Republic of China;2 Medical Technology School, Xuzhou Medical University, Xuzhou, People’s Republic of ChinaORCID Iconhttps://orcid.org/0009-0002-2238-4933View further author information
ORCID Icon,
Shuang Song2 Medical Technology School, Xuzhou Medical University, Xuzhou, People’s Republic of China;3 Department of Clinical Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of ChinaView further author information
,
Senlin Xue2 Medical Technology School, Xuzhou Medical University, Xuzhou, People’s Republic of ChinaView further author information
,
Yingxing Zhu3 Department of Clinical Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of ChinaView further author information
,
Boyin Xu4 Department of Infection Control, Affiliated Hospital of Nantong University, Nantong, People’s Republic of ChinaView further author information
,
Ping Ma2 Medical Technology School, Xuzhou Medical University, Xuzhou, People’s Republic of China;3 Department of Clinical Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of ChinaView further author information
,
Yanguan Lv1 The Huai’an Maternity and Child Clinical College of Xuzhou Medical University, Huai’an, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0009-0009-6990-3009View further author information
ORCID Icon &
Haiquan Kang2 Medical Technology School, Xuzhou Medical University, Xuzhou, People’s Republic of China;3 Department of Clinical Laboratory, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of ChinaCorrespondence[email protected]
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Pages 2625-2639 | Received 17 Jan 2024, Accepted 07 Jun 2024, Published online: 25 Jun 2024

Figures & data

Table 1 Clinical Characteristics of the Children CRKP Strains

Table 2 Clinical Characteristics of the Adults CRKP Strains

Figure 1 Difference in the prevalence of drug sensitivity resistance between children and adults. * is P value <0.05, *** is P value <0.001. The difference is statistically significant.

Figure 1 Difference in the prevalence of drug sensitivity resistance between children and adults. * is P value <0.05, *** is P value <0.001. The difference is statistically significant.

Figure 2 Difference in the detection rates of drug-resistant genotypes between children and adults. * is P value <0.05, ** is P value <0.01, *** is P value <0.001. The difference is statistically significant.

Figure 2 Difference in the detection rates of drug-resistant genotypes between children and adults. * is P value <0.05, ** is P value <0.01, *** is P value <0.001. The difference is statistically significant.

Figure 3 PFGE profile analysis of 62 strains of CRKP in children and adults. The UPGMA algorithm was performed to construct a dendrogram based on the dice similarity coefficient. Strains were classified as the same clone cluster when their dice similarity index was>85%.

Abbreviations: NS, Neurosurgical unit; NSICU, Neurosurgery ICU; NR, Neurology department; NRICU, Neurology ICU; NICU, Neonatal Intensive Care Unit; PICU, Pediatric Intensive Care Unit; EGICU, Emergency ICU; BMTC, Bone Marrow Transplantation Center; UL, Urology Surgery; GT, GI Medicine; CMICU, Critical Care Medicine ICU; REH, Rehabilitation department; RC, Respiratory and Critical Care Department; PED, Pediatric. A, Adult; C, Children.
Figure 3 PFGE profile analysis of 62 strains of CRKP in children and adults. The UPGMA algorithm was performed to construct a dendrogram based on the dice similarity coefficient. Strains were classified as the same clone cluster when their dice similarity index was>85%.

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