https://orcid.org/0000-0002-8315-8895
Figures & data
Table 1 MICs of Thymoquinone and 3-Hydrazinoquinoxaline-2-Thiol in μg/mL for Variety of Clinical Candida Species
Figure 1 (A) Minimum inhibitory concentration (MIC) of 3-hydrazinoquinoxaline-2-thiol was 32 µg/mL and it was reduced to 8 µg/mL (4 fold) when it was combined with thymoquinone against C. albicans 2 (B) MIC of thymoquinone was 16 µg/mL and it was reduced to 1 µg/mL (16 fold) when it was combined with 3-hydrazinoquinoxaline-2-thiol against Candida 2. T represents thymoquinone and Q represents 3-hydrazinoquinoxaline-2-thiol. The experiment was performed in triplicate, and the average value was calculated.
Table 2 The Interaction of 3-Hydrazinoquinoxaline-2-Thiol with Thymoquinone Against Diverse Candida Strains in vitro. Synergy is Considered When the Fractional Inhibitory Concentration Index (FICI) Falls Below 0.5
Figure 2 Checkerboard assay demonstrating the synergistic effect of 3-hydrazinoquinoxaline-2-thiol with thymoquinone against Candida albicans 3. The dark blue color represents 100% growth and the white color represent 0% growth.
