Influence of host resistance on viral adaptation: hepatitis C virus as a case study

Figures & data

Table 1 Genomic heterogeneity of hepatitis C virus (HCV)

Classification	Amino acid diversity across HCV genome (%)
Genotype	20–35
Subtype	10–20
Quasispecies	<5

Note: © Copyright 2011 Los Alamos National Security, LLC All rights reserved. Hepatitis C Virus (HCV) Database Project. Available from: http://hcv.lanl.gov/content/index. Accessed January 8, 2015.¹⁵⁴

Table 2 Genetic variants of genes involved in the host immune response associated with HCV infection outcomea

Family of molecules	Gene
IFN (and targets)	IFNλ3
	ISGs
Cytokines	IL-10
	IL-12β
	TNFα
NK receptors	KIR2DL3
HLA class I	HLA-B27
	HLA-B57
	HLA-DRB1*01
	HLA-DRB1*04
HLA class II	HLA-DRB1*11
	HLA-DQB1*03
	HLA-DQB1*05

Note:

a Genes included only if reported in multiple studies.

Abbreviation: ISGs, IFN-stimulated genes.

Hepatitis C Virus (HCV) Database Project [database on the Internet]Los Alamos National Security Available from: http://hcv.lanl.gov/content/indexAccessed January 8, 2015

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