Moxifloxacin resistance in the F15/LAM4/KZN extensively drug-resistant strain of Mycobacterium tuberculosis

Figures & data

Table 1 RFLP strain families of Mycobacterium tuberculosis isolates stratified by MIC and resistance conferring mutations in the gyrA gene

Strain family	Isolates, n (phenotype)	Mutations associated with resistance	MIC (mg/L)a
			CPX	OFX	MXF
F15/LAM4/KZN	23 (XDR)	A90V	8	8	2
	7 (XDR)	A90V	8	8	1
	4 (MDR)	None	1	1	0.5
	1 (MDR)	None	1	1	0.25
F28	5 (MDR)	None	1	1	0.5
	3 (MDR)	None	1	1	0.25
	1 (MDR)	None	0.5	0.5	0.5
	1 (MDR)	None	0.5	0.5	0.25
LAM3/F11	1 (DS)	None	0.5	0.5	0.125
Beijing family	6 (DS)	None	0.5	0.5	0.125
Unique	3 (DS)	None	0.5	0.5	0.125
	1 (MDR)	None	0.5	0.5	0.25

Note:

a Resistance defined as 2 mg/L for CPX and OFX and 0.5 mg/L for MXF.

Abbreviations: RFLP, restriction fragment length polymorphism; MIC, minimum inhibitory concentration; CPX, ciprofloxacin; OFX, ofloxacin; MXF, moxifloxacin; XDR, extensively multidrug-resistant; MDR, multidrug-resistant; DS, drug-susceptible.