Bacteriotherapy with Streptococcus salivarius 24SMB and Streptococcus oralis 89a nasal spray for preventing recurrent acute otitis media in children: a real-life clinical experience

Figures & data

Table 1 Clinical outcomes

	Subjects	Unchanged	p-value
Groups, n (%)
Group A	108	74 (68.5)
Group B	159	15 (9.4)	<0.0001
Right ear, n (%)
Group A1	78	59 (75.6)
Group B1	101	15 (14.9)	<0.0001
Left ear, n (%)
Group A2	30	15 (50)
Group B2	58	0 (0)	<0.0001

Figure 1 Number of children with recurrence of acute otitis media in group A2 (light grey) and in group B2 (dark gray) who experienced unchanged, 3, 2, or 1, number of acute otitis media episodes.

Abbreviation: RAOM, recurrence of acute otitis media.

Table 2 AOM clinical severity

	Severity grade	p-value
First episode, n (%)
Mild	78 (49)
Moderate	58 (36)
Severe	23 (15)
Successive episodes, n (%)
Mild	96 (81)	p<0.0001 post hoc Bonferroni’s test
Moderate	22 (19)	Mild vs moderate p<0.0001 Mild vs severe p<0.0001
Severe	0 (0)	Moderate vs severe p=0.0136

Abbreviation: AOM, acute otitis media.