Figures & data
Figure 1 (A) Red oval shows location of fatty-degenerative osteolysis of the jawbone; (B) 1:15 scale, morphology of fatty-degenerative osteolysis.
Figure 2 Distribution of 1,25D and 25D in the total study cohort (n=43).
Figure 3 In all five disease groups, the 25D value is above the minimum threshold while the 1,25D value falls within the standard range. (Vitamin D values are shown as mean values.) The distribution of the VDR ratio is greater than the assumed maximum of 1.3 (×10 in the graph) in all five disease groups.
Figure 4 Comparison of the levels of seven cytokines obtained from 19 healthy jawbone samples with those from FDOJ samples from 43 patients with ISDs.
Figure 5 Distribution of seven cytokines in the FDOJ samples obtained from five disease groups: atypical facial and trigeminal pain (n=9); neurodegenerative disorders (multiple sclerosis and amyotrophic lateral sclerosis) (n=5); tumors (breast cancer and prostate cancer) (n=5); rheumatism (fibromyalgia and Lyme disease) (n=8); and chronic fatigue syndrome (n=8). There was significant overexpression of R/C in all groups; there were no statistically significant differences between the individual groups (Kruskal–Wallis).
Figure 6 Correlation (value/r=0.13) between R/C expression in the FDOJ samples and the VDR-deac levels. Spearman’s correlation coefficient is not significant (P=0.39).
Figure 7 (A) A cluster of dead fatty cells (white arrow) with small inflammatory cells observed in the medullary cavity of the jaw. (B) An FDOJ tissue sample with complete fatty transformation of the cancellous portion of the jawbone (blue arrow).
Figure 8 Interconnection between deactivated VDR, autoimmune and systemic diseases, disturbed bone metabolism and fatty-degenerative osteolysis of the jawbone with an immunological amplification loop.
