Reducing Perioperative Neurocognitive Disorders (PND) Through Depth of Anesthesia Monitoring: A Critical Review

Figures & data

Table 1 Trials Registered with ClinicalTrials.gov Examining the Impact of EEG-Guided Anesthesia Care on Postoperative Delirium

ClinicalTrials.gov Number	Study Title	Actual/Projected Enrollment	Status
NCT01983384	Anesthetic Depth and Postoperative Delirium Trial - 2	205	Completed; results published - Tang et al 2020^Citation42
NCT02133430	Optimized Anesthesia to Reduce Incidence of Postoperative Delirium	140	Status unknown: Last update posted: May 12, 2014
NCT02382445	Anesthesia Depth Increases the Degree of Postoperative Dementia, Delirium, and Cognitive Dysfunction (BIS & Dementia)	138	Completed: Last update posted: May 9, 2017
NCT02604459	Does Optimized General Anesthesia Care Reduce Postoperative Delirium?	160	Status unknown: Last update posted: June 1, 2017
NCT02692300	EEG Guidance of Anesthesia (ENGAGES-CANADA)	1200	Recruiting
NCT02698982	Optimized Anesthesia to Reduce Postoperative Cognitive Impairment in the Elderly	41	Completed: Last update posted: Dec. 26, 2017
NCT03330236	EEG - Guided Anesthetic Care and Postoperative Delirium (EMODIPOD)	1560	Completed: Last update posted: Sept. 25, 2019
NCT03705728	Automated Administration of Intravenous Compared With Inhalatory Anesthesia on the Occurrence of Postoperative Delirium	1000	Recruiting
NCT03706989	Predicting Postoperative Delirium Using EEG, Genetics and Neurobiomarkers of Cerebral Injury (POD-01)	480	Recruiting
NCT03775356	Reduction of Intraoperative EEG Burst Suppression (BsR)	66	Recruiting
NCT04246320	Taking Brain Monitoring to the Next Level	60	Recruiting
NCT04292561	Intraoperative EEG Monitoring and Postoperative Delirium in Elderly Patients With Sevoflurane Anesthesia	500	Recruiting
NCT04443517	Modulation Of Frontal EEG Alpha Oscillations During Maintenance and Emergence Phases of General Anesthesia	600	Not yet recruiting

Tang CJ, Jin Z, Sands LP, et al. ADAPT-2: a randomized clinical trial to reduce intraoperative EEG suppression in older surgical patients undergoing major noncardiac surgery. Anesth Analg. 2020;131(4):1228–1236. doi:10.1213/ANE.0000000000004713

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