The Effect of Hemodialysis on Axial Length, Ocular Surface, and Intraocular Pressure in Patients with End-Stage Renal Failure

Figures & data

Table 1 Distribution of Patients with Chronic Renal Failure According to Etiological Causes

Etiology	Number of Patients (%)
Diabetes mellitus	44 (39.3)
Systemic hypertension	26 (23.2)
Primary glomerulonephritis	12 (10.7)
Interstitial nephritis/pyelonephritis	11 (9.8)
Secondary glomerulonephritis	9 (8)
Cystic, hereditary and congenital diseases of the kidney	6 (5.4)
Other causes	4 (3.6)

Table 2 Effect of Hemodialysis on BCVA, IOP, CCT, Axial Length, and Ocular Surface in Patients with Chronic Renal Failure

Variable	Before Hemodialysis Mean ± SD	After Hemodialysis Mean ± SD	Difference Mean ± SD	P value
BCVA (LogMAR)	0.49 ± 0.42	0.49 ± 0.42	0 ± 0.03	0.866
Spherical equivalent, (D)	−0.43 ± 0.26	−0.45 ± 0.22	−0.02 ± 0.04	0.524
IOP (mmHg)	12.2 ± 3.5	10.8 ± 2.2	1.4 ± 2	<0.001
CCT (μm)	502 ± 41.2	494.1 ± 35.4	8.1 ± 7.7	<0.001
Axial length (mm)	23.1 ± 0.8	22.9 ± 0.8	0.26 ±0.15	<0.001
BUT (sec)	7.4 ± 3.1	6.3 ± 2.5	1 ± 0.9	<0.001
BST (mm)	8.6 ± 1.7	6.6 ± 1.3	2 ± 0.7	<0.001
Keratoepitheliopathy score	0.36 ± 0.61	1.59 ± 0.93	−1.2 ± 0.7	<0.001

Abbreviations: BCVA, best-corrected visual acuity; D, dioptry; IOP, intraocular pressure; CCT, central corneal thickness; SD, standard deviation; BUT, tear breakup time; BST, basal secretion time.

Figure 1 Correlation between axial length and intraocular pressure.

Table 3 Effect of Hemodialysis on Systemic Hemodynamic Parameters in Patients with Chronic Renal Failure

Variable	Before Hemodialysis Mean ± SD	After Hemodialysis Mean ± SD	Difference Mean ± SD	P value
Serum osmolarity (mOsm/L)	345 ± 31.8	326.3 ± 32	18.6 ± 3	<0.001
Plasma colloid osmotic pressure (mmHg)	25.3 ± 1	27.9 ± 1.4	−2.5 ± 0.4	<0.001
MABP (mmHg)	120.6 ± 29.4	108.7 ± 25.4	11.8 ± 5	<0.001
MOPP	49.2	44.3	−4.9 ± 13.7	<0.001
Body weight (kg)	60.8 ± 7.1	59.5 ± 6.7	1.2 ± 2.4	<0.001

Abbreviations: MABP, mean arterial blood pressure; MOPP, mean ocular perfusion pressure.