Risk Factors and Psychological Analysis of Chronic Immune Thrombocytopenia in Children

Figures & data

Table 1 Comparison of Gender and Age Between Children with Chronic ITP and Children with Non-Chronic ITP

		Gender		Age(Year)
	Total	Male	Female	≤1	1–7	≥7
CITP	34	16	18	4	21	9
NCITP	200	127	73	84	65	51
χ^2	3.305				13.846
P value	0.069				0.001

Table 2 Comparison of the Degree of Bleeding and the Course of the Initial Diagnosis Between Children with Chronic ITP and Children with Non-Chronic ITP

		Degree of Bleeding			Initial Diagnosis(Month)
	Total	Asymptomatic and Mild	Moderate	Severe	<1	≥1
CITP	34	7	17	10	26	8
NCITP	200	70	92	38	183	17
χ^2	3.470				6.879
P value	0.176				0.009

Table 3 Comparison of PLT Antibodies, PLT Counts and Newly Diagnosed Megakaryocytes in Children with Chronic ITP and Non-Chronic ITP Children

		PLT Antibody		PLT Count (×10^9/L)			Megakaryocyte Count
	Total	Negative	Positive	≤10	10–20	≥20	Increase	Normal
CITP	34	30	4	17	9	8	29	5
NCITP	200	172	28	97	39	64	164	36
χ^2	0.123			1.379			0.218
P value	0.726			0.502			0.640

Table 4 Comparison of Cytomegalovirus Infection and Newly Diagnosed ALC in Children with Chronic ITP and Non-Chronic ITP Children

		Cytomegalovirus			ALC
	Total	Positive	Negative	Increase	Normal	Decrease
CITP	34	7	27	13	13	8
NCITP	200	76	124	113	67	29
χ^2	3.849				6.436
P value	0.050				0.040

Table 5 Comparison of Treatment Methods Between Children with Chronic ITP and Children with Non-Chronic ITP

	Treatment
	Total	Immunoglobulin	Hormones	Immunoglobulin & Hormones	Other
CITP	34	2	1	24	7
NCITP	200	20	8	132	40
χ^2	0.706
P value	0.872

Table 6 The Relationship Between Age, First-Diagnosed Disease Course and First-Diagnosed ALC and Chronic ITP

Index	Estimate	Standard Error	Wald	DF	P	95% Confidence Interval
						Upper Limit	Lower Limit
Age	−0.005	0.005	0.889	1	0.346	0.986	1.005
Initial diagnosis	0.003	0.002	1.060	1	0.303	0.998	1.007
ALC	−0.443	0.129	11.825	1	0.001	0.499	0.826

Figure 1 The area under the curve for the first diagnosed ALC to predict ITP.

Table 7 EPQ Psychological Evaluation Analysis of Children with Chronic ITP and Normal Children

	P	E	N	L
CITP (n=24)	46.17±3.60	38.54±3.89	47.92±5.16	53.92±6.39
Normal child (n=24)	45.54±3.45	43.04±5.01	46.75±5.45	52.79±4.47
t	0.614	−3.476	0.762	0.706
P	0.542	0.001	0.450	0.484

Figure 2 EPQ psychological evaluation of children with chronic ITP and normal children (***p<0.05).

Table 8 EPQ Psychological Evaluation of Children with Chronic ITP and Newly Diagnosed Children with ITP

	P	E	N	L
CITP (n=24)	46.17±3.60	38.54±3.89	47.92±5.16	53.92±6.39
Newly diagnosed ITP (n=51)	45.00±2.47	41.98±4.52	45.96±4.20	50.31±5.21
t	1.438	−3.208	1.747	2.596
P	0.160	0.002	0.085	0.011

Figure 3 EPQ psychological evaluation of children with chronic ITP and newly diagnosed children with ITP (**p<0.05, *p<0.05).

Table 9 EPQ Psychological Evaluation of Children with Chronic ITP and Children with Persistent ITP

	P	E	N	L
CITP (n=24)	46.17±3.60	38.54±3.89	47.92±5.16	53.92±6.39
Persistent ITP (n=32)	46.03±3.23	40.16±5.47	46.69±4.77	52.56±4.33
t	0.148	−1.290	0.922	0.895
P	0.883	0.202	0.361	0.376

Figure 4 EPQ psychological evaluation of children with chronic ITP and children with persistent ITP.