Correlation Between Level of Interleukin-37 and Rheumatoid Arthritis Progression

Figures & data

Table 1 Characteristics of All Participants

Characteristics	Remission (n=20)	Mild (n=23)	Moderate (n=22)	Severe (n=22)	Healthy Volunteers (n=18)	P value
Age (year)	50.15±11.32	51.17±14.42	49.36±12.4	50.09±11.94	50.33±12.54	0.9934
Gender (Male:Female)	11:9	11:12	12:10	13:9	9:9	0.8562
BMI (kg/m2)	23.01±1.7	22.74±1.75	23.62±1.84	22.92±1.92	22.53±1.15	0.3122
DAS28	1.86±0.52	2.92±0.14	4.09±0.58	6.87±1.07

Figure 1 Serum IL-37 level is positively correlated with the RA progression. (A) Serum IL-37 level comparison in the 5 groups of participants. P<0.0001 is the One-way ANOVA analysis among the 5 groups. (B) Correlation analysis of serum IL-37 level and the DAS28 in all RA patients. (C) ROC of serum IL-37 level and the DAS28 in all RA patients.

Figure 2 IL-37 mRNA expression level in PBMC is positively correlated with the RA progression. (A) IL-37 mRNA expression level in PBMC comparison in the 5 groups of participants. P<0.0001 is the One-way ANOVA analysis among the 5 groups. (B) Correlation analysis of IL-37 mRNA expression level in PBMC and the DAS28 in all RA patients. (C) ROC of IL-37 mRNA expression level in PBMC and the DAS28 in all RA patients. Y axis in (A) and (B) is the 2^−ΔΔCt value of IL-37 normalized to the 2^−ΔΔCt value of β-actin.

Figure 3 IL-37 mRNA expression level in synovial cells is positively correlated with the RA progression. (A) Correlation analysis of IL-37 mRNA expression level in synovial cells and the DAS28 in RA patients of the severe group. Y axis is the 2^−ΔΔCt value of IL-37 normalized to the 2^−ΔΔCt value of β-actin. (B) ROC of IL-37 mRNA expression level in synovial cells and the DAS28 in RA patients of the severe group.