Factors Affecting Artificial Insemination Pregnancy Outcome

Figures & data

Table 1 Characteristics of Patient Undergoing All Cycles with IUI

Variable	Mean ± SD
Female age (year)	30.30±4.82
Male age (year)	31.08±4.95
Body mass index (kg/m^2)	23.69±3.71
Infertility years (year)	3.19±2.20
Baseline FSH (IU/L)	6.92±2.95
Baseline LH (IU/L)	6.27±2.85
Baseline estrogen (pmol/L)	144.85±100.21
Baseline T (nmol/L)	1.33±3.23
Baseline PRL (mIU/L)	392.36±249.91

Table 2 Comparison of the Female Age, Male Age, Endometrial Thickness on IUI Day and PTMC Between Pregnant Group and Non-Pregnant Group

	Female Age (y)	Male Age (y)	Endometrial Thickness (mm)	PTMC (×10^6/mL)
Non-pregnant group	30.47±4.84	31.28±5.00	10.25±2.10	17.89±14.57
Pregnant group	28.97±4.06	29.84±4.31	10.46±2.02	19.54±16.14
T value	8.468	7.229	−2.253	−2.638
P value	0.000	0.000	0.026	0.009

Table 3 The Clinical Pregnancy Rate According to Female Age and Male Age

	Female Age (y)			Male Age (y)
	<25 (a)	25–35 (b)	>35 (c)	<25 (a)	25–35 (b)	>35 (c)
Non-pregnant group	441 (76.2%)	2355 (83.7%)	540 (91.2%)	320 (76.2%)	2410 (83.4%)	605 (89.9%)
Pregnant Group	138 (23.8%)	458 (16.3%)	52 (8.8%)	100 (23.8%)	481 (16.6%)	68 (10.1%)
χ^2 value	48.628			36.557
P value	0.000			0.000

Notes: Pairwise comparison in female age group [χ² (P)]. P<0.05: a: b 18.709 (0.000); a: c 48.779 (0.000); b: c 27.760 (0.000). Pairwise comparison in male age group [χ² (P)]. P<0.05: a: b 13.036 (0.000); a: c 37.344 (0.000); b: c 17.885 (0.000)

Table 4 The Clinical Pregnancy Rate According to Endometrial Thickness on IUI Day and PTMC

	Endometrial Thickness (mm)			PTMC (×10^6/mL)
	<8 (a)	8–12 (b)	>12 (c)	<5 (a)	5–10 (b)	10–20 (c)	>20 (d)
Non-pregnant group	688 (86.5%)	2175 (83.0%)	472 (83.0%)	553 (85.2%)	692 (85.6%)	949 (82.7%)	1141 (82.7%)
Pregnant group	107 (13.5%)	445 (17.0%)	97 (17.0%)	96 (14.8%)	116 (14.4%)	199 (17.3%)	238 (17.3%)
χ^2 value	5.839			5.151
P value	0.054			0.161

Notes: Pairwise comparison in Endometrial thickness group [χ² (P)]. P<0.05: a: b 5.595 (0.018); P>0.05: a: c 3.357 (0.076); b: c 0.001 (0.951). Pairwise comparison in PTMC group [χ² (P)]. P>0.05: a: b 0.050 (0.823); a: c 1.953 (0.165); a: d 1.952 (0.178); b: c 3.113 (0.080); b: d 3.164 (0.081); c: d 0.003 (0.958).

Table 5 The Clinical Pregnancy Rate According to the Frequency and Timing of IUI

	The Frequency of IUI		The Timing of IUI
	Single IUI (a)	Double IUI (b)	a	b	c	d
Non-pregnant group	946 (87.8%)	2389 (82.2%)	356 (88.1%)	589 (87.8%)	2063 (81.3%)	327 (88.1%)
Pregnant group	131 (12.1%)	518 (17.8%)	48 (11.9%)	82 (11.9%)	475 (18.7%)	44 (11.9%)
χ^2 value	18.433		30.197
P value	0.000		0.000

Notes: The timing of IUI: a. Ovulation after a single IUI; b. Ovulation before a single IUI; c. double IUI before and after ovulation, and the ovulation was observed within the next day of the first IUI; d. double IUI before and after ovulation, and the ovulation was observed after the next day of the first IUI. Pairwise comparison [χ² (P)]. P<0.05: a: c 11.137 (0.001); b: c 15.607 (0.000); c: d 10.379 (0.001). P>0.05: a: b 0.027 (0.923); a: d 0.000 (1.000); b: d 0.029 (0.921).

Table 6 The Clinical Pregnancy Rate According to Treatment Protocol

	Treatment Protocol		Ovarian Stimulation Protocol
	Natural Cycle	Ovarian Stimulation Cycle	LE (a)	CC (b)	LE+HMG (c)	CC+HMG (d)	HMG (e)
Non-pregnant group	1795 (88.4%)	1540 (78.8%)	263 (86.5%)	94 (86.2%)	476 (72.9%)	104 (78.2%)	603 (79.9%)
Pregnant group	235 (11.6%)	414 (21.2%)	41 (13.5%)	15 (13.8%)	177 (27.1%)	29 (21.8%)	152 (20.1%)
χ^2 value	67.442		28.626
P value	0.000		0.000

Notes: Pairwise comparison [χ² (P)]. P<0.05: a: c 21.871 (0.000); b: c 8.825 (0.003); a: d 4.758 (0.034); a: e 6.423 (0.011); c: e 9.508 (0.002). P>0.05: a: b 0.005 (1.000); b: e 2.479 (0.121); c: d 1.606 (0.234); d: e 0.195 (0.642); b: d 2.605 (0.132).