Altered Expression of Angiogenic Biomarkers in Pregnancy Associated with Gestational Diabetes

Figures & data

Table 1 Clinical Characteristics of Pregnant Women Participating in the Present Study

Variables	GDM (n = 10)	NP (n = 9)	P-value
Age (years)	32.7 ± 7.1	33 ± 8	NS
Gestational age (weeks)	26.4 ± 2.7	25.5 ± 1.8	NS
Gravidity	4.8 ± 3.1	4. 6 ± 3.6	NS
Parity	2.1 ± 1.7	3.7± 2	NS
Abortion or IUFD	2.7 ± 1.4	0.9 ± 1.6	NS
BMI	30.5 ± 5	28 ± 5.7	NS
RBS	7.8 ± 2.5	4.6 ± 0.7	0.013
GTT
Fasting	5.6 ± 0.8	-
2hrs	9.8 ± 2.5	-

Abbreviations: BMI, body mass index; GDM, gestational diabetes mellitus; IUFD, intrauterine fetal death; NS, not significant; RBS, random blood sugar; GTT, glucose tolerance test.

Figure 1 Comparison of angiopoietin-2 (pg/mL) levels between control pregnant and GDM-samples. Data are expressed as mean ± standard error. ***P = 0.001 compared to control.

Figure 2 Comparison of VEGF-A (pg/mL) levels between control pregnant and GDM-samples. Data are expressed as mean ± standard error. ***P = 0.001 compared to control.

Figure 3 Comparison of endoglin (pg/mL) levels between control pregnant and GDM-samples. Data are expressed as mean ± standard error. *P < 0.05 compared to control.

Figure 4 Comparison of endothelin (pg/mL) levels between control pregnant and GDM-samples. Data are expressed as mean ± standard error. *P < 0.05 compared to control.

Figure 5 Correlations between endoglin and angiopoietin −2 in control group. The correlation coefficient was made using the Person test.

Figure 6 Correlations between angiopoietin −2 and endoglin (A), angiopoietin −2 and endothelin-1 (B) and angiopoietin −2 and VEGF- A (C) in GDM patients. Correlation coefficient was made using Pearson test.

Figure 7 Correlations between G-CSF and endothelin-1 in GDM patients. The correlation coefficient was made using the Pearson test.

Figure 8 Correlations between endoglin and VEGF-A (A) and endothelin-1 and VEGF-A (B) in GDM patients. The correlation coefficient was made using the Pearson test.