Continuous Theta-Burst Stimulation Over the Right Orbitofrontal Cortex in Treatment-Resistant Obsessive-Compulsive Disorder Treatment: A Randomized Sham-Controlled Trial

Figures & data

Figure 1 Consort diagram.

Table 1 Baseline Characteristics

Variable	Active Group(n = 12) Mean (SD), n(%)	Sham Group (n = 11) Mean (SD), n(%)	p
Age, y	28.17 (9.81)	31(7.50)	0.296
Sex (male/female)	5/7	5/6	1.000
Age at onset, y	19.92(6.01)	20.72(5.31)	0.241
Duration of illness, y	8.25(7.66)	10.27(5.10)	0.573
Medication in use
Antidepressant	11(91.67)	11(100)	1.000
Antipsychotics	2(16.67)	3(27.27)	0.640
Benzodiazepine	1(8.33)	2(18.18)	0.590
Y-BOCS	26.33(2.81)	28.27(5.00)	0.275
HAMA	10.08(5.47)	10.91(6.99)	0.754
HAMD	13.58(6.37)	9.45(4.99)	0.100

Table 2 Clinical Outcome

Scale	Active, Mean(SD)	Sham, Mean (SD)	ANOVA Time Effect		ANOVA Group*Time Interaction
			F	p	F	p
Y-BOCS
Week 0	26.33(2.81)	28.27(5.00)	*F2,20=4.743	0.021	*F2,20=0.996	0.387
Week 2	24.75(2.38)	25.09(4.32)
Week 6	23.50(3.97)	24.82(3.82)
HAMD-17
Week 0	13.58(6.37)	9.45(4.99)	*F2,20=16.544	<0.001	*F2,20=4.132	0.031
Week 2	6.42(4.58)	7.09(2.21)
Week 6	5.17(2.66)	6.64(2.50)
HAMA
Week 0	10.08(5.47)	10.91(6.99)	*F2,20=9.509	0.001	*F2,20=0.584	0.567
Week 2	7.17(2.82)	8.36(4.99)
Week 6	6.08(2.91)	8.00(4.56)

Note: *Correction for nonsphericity.

Abbreviation: ANOVA, analysis of variance.

Table 3 Comparison of the Effective Rate After Treatment in Active and Sham Groups

	Time	Active (%)	Sham (%)	x^2	p
Y-BOCS	2w	16.67	9.09	0.290	1.000
	6w	25	18.18	0.157	1.000
HAMA	2w	41.67	45.45	0.034	1.000
	6w	58.33	63.64	0.068	1.000
HAMD	2w	91.67	45.45	5.789	0.027
	6w	83.33	45.45	3.630	0.089

Figure 2 Y-BOCS scores in active and sham cTBS groups.

Figure 3 Comparison of mean HAMA scores in active and sham groups.

Figure 4 Comparison of mean HAMD scores in active and sham groups.*p<0.05.