Influencing Factors and Prognostic Value of ¹⁸F-FDG PET/CT Metabolic and Volumetric Parameters in Non-Small Cell Lung Cancer

Figures & data

Table 1 Key Characteristics of Patients

Variable Value	Value
Sex
Male	92
Female	41
Age
Range	38–85 year
Mean	65.72±9.61 year
Serum glucose concentration
Range	4.10–7.80 mmol/l
Mean	6.40±1.06 mmol/l
Pathology type
Adenocarcinoma (AC)	95
Squamonoma (SCC)	38
TNM stage
I	50
II	5
III	26
IV	52
Overall Survival rate
One year	77.04%
Two year	60.00%

Table 2 Metabolic and Volumetric Parameters of Different Pathological Types of NSCLC

Parameters	Type	Number	Mean	SD	Median	Min	Max	Z	P
SUVmax_early	AC	95	9.50	7.17	8.67	0.28	30.99	−3.178	0.001
	SCC	38	13.42	6.66	12.59	3.47	35.91
SUVpeak_early	AC	95	6.44	5.35	5.19	0.10	21.74	−2.792	0.005
	SCC	38	8.91	5.66	8.28	1.99	29.03
SULmax_early	AC	95	10.82	8.40	9.53	0.37	34.63	−3.290	0.001
	SCC	38	15.24	6.91	15.77	3.55	31.33
SULpeak_early	AC	95	7.29	6.82	5.61	0.11	44.62	−3.135	0.002
	SCC	38	10.03	5.65	10.30	2.32	25.32
TLG_early	AC	95	152.33	297.98	22.54	0.31	1510.37	−2.595	0.009
	SCC	38	270.87	515.51	102.43	2.85	2787.70
MTV_early	AC	95	55.81	131.44	7.36	0.16	603.88	−1.821	0.069
	SCC	38	77.69	168.76	22.79	0.16	853.33
SUVmax_delayed	AC	95	10.99	8.50	9.65	0.30	38.19	−3.671	0.000
	SCC	38	16.58	8.28	17.08	4.20	45.94
SUVpeak_delayed	AC	94	7.20	6.02	5.60	0.10	25.00	−3.116	0.002
	SCC	37	10.70	7.01	9.80	2.23	38.14
SULmax_delayed	AC	95	12.37	9.63	10.98	0.41	38.09	−3.608	0.000
	SCC	38	18.53	8.60	20.18	4.30	40.07
SULpeak_delayed	AC	95	12.35	45.35	6.35	0.20	445.62	−3.529	0.000
	SCC	38	12.11	6.89	12.53	2.52	33.27
TLG_delayed	AC	95	169.93	336.32	28.42	0.21	1798.68	−2.866	0.004
	SCC	38	343.87	737.40	120.90	3.20	4268.50
MTV_delayed	AC	95	56.71	131.17	7.92	0.16	624.00	−1.835	0.066
	SCC	38	81.23	195.65	20.36	0.30	1097.60

Table 3 The Relationship Between Metabolic and Volumetric Parameters and Serum Tumor Markers

Parameters	Marker	R	SE	Coefficients	Standardized Coefficients	F	t	P
SUVmax_early	NSE	0.198	0.039	0.134	0.198	5.447	2.334	0.021
SUVpeak_early		0.251	0.063	0.130	0.251	8.913	2.985	0.003
SULmax_early		0.224	0.050	0.173	0.224	7.040	2.653	0.009
SULpeak_early		0.271	0.073	0.168	0.271	10.543	3.247	0.001
TLG_early		0.371	0.138	12.999	0.371	21.287	4.614	0.000
MTV_early		0.574	0.330	7.647	0.574	65.418	8.088	0.000
SUVmax_delayed		0.223	0.050	0.184	0.223	6.954	2.637	0.009
SULmax_delayed		0.241	0.058	0.220	0.241	8.195	2.863	0.005
TLG_delayed		0.290	0.084	13.222	0.290	12.188	3.491	0.001
MTV_delayed		0.541	0.292	7.665	0.541	54.902	7.410	0.000
TLG_early	CYFRA211	0.269	0.072	1.606	0.269	10.368	3.220	0.002
MTV_early		0.389	0.151	0.883	0.389	23.646	4.863	0.000
TLG_delayed		0.244	0.060	1.901	0.244	8.435	2.904	0.004
MTV_delayed		0.461	0.212	1.115	0.461	35.874	5.989	0.000
MTV_early	SCC-ag	0.347	0.120	0.929	0.347	18.218	4.268	0.000
MTV_delayed		0.343	0.118	0.978	0.343	17.754	4.214	0.000

Table 4 The Relationship Between Metabolic and Volumetric Parameters and P53

Parameters	Marker	R	SE	Coefficients	Standardized Coefficients	F	t	P
SUVpeak_early	P53	0.174	0.030	2.859	0.174	4.137	2.034	0.044
SULmax_early	P53	0.171	0.029	4.188	0.171	4.028	2.007	0.047

Table 5 The Correlation of Metabolic and Volumetric Parameters and TNM Stage

Dependent Variable	Predictor Variable	Correlation Index	P
SUVmax_early	TNM	0.501	<0.001
SUVpeak_early	TNM	0.525	<0.001
SULmax_early	TNM	0.505	<0.001
SULpeak_early	TNM	0.532	<0.001
TLG_early	TNM	0.612	<0.001
MTV_early	TNM	0.547	<0.001

Figure 1 The receiver operating characteristics curves. The ROC curves for the optimal cut-off of (A) early SULpeak and delayed MTV of 1-year OS, and (B) early SUVpeak, delayed TLG and delayed MTV of 2-year OS.