Differential Expression of COL1A1, COL1A2, COL6A3, and SULF1 as Prognostic Biomarkers in Gastric Cancer

Figures & data

Figure 1 The top 20 genes upregulated in microarrays. COL1A1, COL1A2, COL6A3, and SULF1 mRNA were statistically significantly overexpressed in Chen Gastric,¹⁰ Cho Gastric,¹¹ Cui Gastric,¹² and Wang Gastric¹³ datasets from the ONCOMINE database. Genes with red had significant and consistent overexpression in the five studies.

Figure 2 Correlation between different expressed COL1A1, COL1A2, COL6A3, and SULF1 chemokines, and the tumor node metastasis (TNM) stage of gastric cancer patients (GEPIA2) p < 0.05.

Figure 3 Pearson correlation analyses between ERBB2 and COL1A1, COL1A2, COL6A3, and SULF1 genes.

Figure 4 Protein-protein interaction network of different expressions of COL1A1, COL1A2, COL6A3, and SULF1 genes. (A) related to COL1A1; (B) related to COL6A3; (C) related to SULF1 genes.

Figure 5 The prognostic value of different expressed COL1A1, COL1A2, COL6A3, and SULF1 chemokines in gastric cancer patients in the overall survival curve (Kaplan–Meier plotter).

Figure 6 The correlation between different expressions of COL1A1, COL1A2, COL6A3, and SULF1 chemokines and immune cell infiltration (TIMER).

Chen X, Leung SY, Yuen ST, et al. Variation in gene expression patterns in human gastric cancers. Mol Biol Cell. 2003;14(8):3208–3215. doi:10.1091/mbc.e02-12-0833

 PubMed Web of Science ®Google Scholar

Cho JY, Lim JY, Cheong JH, et al. Gene expression signature-based prognostic risk score in gastric cancer. Clin Cancer Res. 2011;17(7):1850–1857. doi:10.1158/1078-0432.CCR-10-2180

 PubMed Web of Science ®Google Scholar

Cui J, Chen Y, Chou WC, et al. An integrated transcriptomic and computational analysis for biomarker identification in gastric cancer. Nucleic Acids Res. 2011;39(4):1197–1207. doi:10.1093/nar/gkq960

 PubMed Web of Science ®Google Scholar

Wang J, Yang YH, Wang AQ, et al. Immunohistochemical detection of the Raf kinase inhibitor protein in nonneoplastic gastric tissue and gastric cancer tissue. Med Oncol. 2010;27(2):219–223. doi:10.1007/s12032-009-9194-z

 PubMed Web of Science ®Google Scholar