https://orcid.org/0000-0001-5510-8172
Figures & data
Figure 1 The mutation pattern of CSMD1 in gastric cancer. (A) CSMD1 was 13th mutated gene in gastric cancer. (B) Mutation pattern of CSMD gene family and genes associated with genomic instability TCGA.
Figure 2 Association of CSMD1 mutation with TMB, expression of PDL1, MSI and survival. (A) TMB of gastric cancer classified by CSMD1 mutation status. (B) Expression of PDL1 with CSMD1 mutation was upregulated. (C) The ratio of MSI-H in CSMD1 mutation group was increased in GC (D) patients with CSMD1 mutation had better survival than patients without CSMD1 mutation. (*p < 0.05, *** p < 0.001).
Figure 3 Correlation of CSMD1 mutation and TBM and survival outcome. (A) TMB was related to CSMD1 mutation according to general linear analysis. (B) CSMD1 mutation was associated with survival outcome through multivariate Cox regression analysis.
Figure 4 CSMD1 mutation was associated with neoantigens. Compared with non-CSMD1 mutation patients, the CSMD1 mutation group has more activated CD4+ T cells (A), more neoantigens (B and C) and dissimilarity (D). (*p < 0.05, **p < 0.01).
