Multiple Organ Dysfunction Syndrome Caused by Sepsis: Risk Factor Analysis

Figures & data

Table 1 SOFA Scoring Criteria

System	Score/Points
	0	1	2	3	4
Respiratory system	≥400(53.3)	<400(53.3)	<300(40.0)	<200(26.7) + Mechanical ventilation	<100(13.3) + Mechanical ventilation
PaO2/FiO2/mmHg(kPa)
Coagulation system	≥150	<150	<100	<50	<20
Blood platelet/(10^3•μL^−1)
Liver	<1.2(20)	1.2–1.9(20–32)	2.0–5.9(33–101)	<6.0–11.9(102–204)	≥12.0(204)
Bilirubin /[mg•dl^−1(μmol•L^−1)]
Cardiovascular system	MAP≥70mmHg	MAP<70mmHg	Dopamine <5 or dobutamine (any dose)	Dopamine 5.1–15.0 or epinephrine ≤0.1 or norepinephrine >0.1	Dopamine >15 or adrenaline >0.1 or norepinephrine >0.1
Central nerve system (GCS)	15	13–14	10–12	6–9	<6
Kidney	<1.2(110)	1.2–1.9(110–170)	2.0–3.4(171–299)	3.5–4.9(300–400)	>4.9(440)
Creatinine /[mg•dl^−1(μmol•L^−1)]
Urine Volume (mL•d^−1)	–	–	–	<500	<200

Table 2 MODS Score (Marshall Standard)

Organ	Score
	0	1	2	3	4
Respiratory system (PaO2/FiO2)	>300	226–300	151–225	76–150	≤75
Kidney (Blood Crμmol•L^−1)	≤100	101–200	201–350	351–500	>500
Liver (hemobilirubin μmol•L^−1)	≤20	21–60	61–120	121–240	>240
Cardiovascular system (PAR=HR×CVP/MAP)	≤10.0	10.1–15.0	15.1–20.0	20.1–30.0	>30.0
Blood (platelet count 10^9•L^−1)	>120	81–120	51–80	21–50	≤20
Nerve system (Glasgow Coma score)	15	13–14	10–12	7–9	≤6

Table 3 Comparison of Measurement Data Between the Two Groups (±s)

Observation Index	MODS Group (n=90)	Non-MODS Group (n=90)	P
Age (year old)	46.04±17.42	43.83±15.21	0.366
Body temperature (°C)	38.53±0.91	38.58±0.94	0.717
Heart rate (times/min)	113.80±18.07	110.92±16.81	0.269
Respiration (times/min)	29.44±6.42	27.84±5.05	0.065
MAP (mmHg)	88.15±19.35	90.42±18.01	0.416
Arterial blood Ph value	8.42±0.23	7.45±0.08	<0.001
RBC specific volume (%)	34.42±9.95	36.76±9.28	0.105
WBC count (×10^9•L^−1)	19.88±5.34	16.86±5.91	<0.001
APACHE II Score (points)	26.14±11.36	16.13±6.86	<0.001
Blood sodium (mmol•L^−1)	138.88±8.67	138.05±7.11	0.483
Serum kalium (mmol•L^−1)	5.38±0.92	5.35±0.64	0.799
Blood glucose (mmol•L^−1)	21.33±6.30	10.65±3.92	<0.001
Creatinine (μmol•L^−1)	185.46±235.16	84.03±94.51	<0.001

Table 4 Comparison of Enumeration Data Between the Two Groups [n (%)]

Observation Index	MODS Group (n = 90)	Non-MODS Group (n = 90)	P
Gender (Male/Female)	71/19	58/32	0.032
History of chronic disease (Yes/No)	36/54	17/73	0.002
Infection site (Respiration system/Other than Respiration system)	73/17	81/9	0.090
Surgery (Surgery/Non-surgery)	39/51	54/36	0.025
Bacteria culture growth (Yes/No)	35/55	53/37	0.007
Ventilator usage (Applied/Not applied)	76/14	85/5	0.029

Table 5 Logistic Regression Analysis of Risk Factors for MODS in Sepsis Patients

Factors	Estimated Parameter	P value	OR Value	95% CI
Bacterial culture growth	−1.776	0.032	0.275	0.045, 0.787
Increased creatinine level	0.061	<0.001	1.062	1.028, 1.075
Combined chronic diseases	−1.758	0.029	0.204	0.049, 0.768
Increased APACHE II score	0.339	<0.001	1.367	1.132, 1.394

Figure 1 Site composition of primary infection in patients with sepsis.

Figure 2 Disease distribution.