Figures & data
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Table 1 Clinical Characteristics and Therapy Information in TCGA Cohort
Figure 1 The preliminary selection of candidate prognostic genes by Lasso methods. (A) Ten-time cross-validation for tuning parameter selection in the Lasso model. (B) Partial likelihood deviation map with Lasso approach. (C) Coeff-values of the preliminary selected 24 genes. (D) ROC curve for the preliminary selected 24 genes.
![Figure 1 The preliminary selection of candidate prognostic genes by Lasso methods. (A) Ten-time cross-validation for tuning parameter selection in the Lasso model. (B) Partial likelihood deviation map with Lasso approach. (C) Coeff-values of the preliminary selected 24 genes. (D) ROC curve for the preliminary selected 24 genes.](/cms/asset/69650c5d-d089-409b-9eeb-bb0a7892f89a/dijg_a_12168402_f0001_c.jpg)
Figure 2 Kaplan–Meier curves of the five-gene signature for high- (n = 136) and low-risk (n = 136) patients with lower-grade gliomas in TCGA database.
![Figure 2 Kaplan–Meier curves of the five-gene signature for high- (n = 136) and low-risk (n = 136) patients with lower-grade gliomas in TCGA database.](/cms/asset/49022cc5-3672-4209-9122-8c267e381dd9/dijg_a_12168402_f0002_c.jpg)
Figure 3 Kaplan–Meier curves of the five-gene signature for high- (n = 136) and low-risk (n = 136) patients with lower-grade gliomas stratified by age, gender, tumor grade, and seizures status in TCGA database.
![Figure 3 Kaplan–Meier curves of the five-gene signature for high- (n = 136) and low-risk (n = 136) patients with lower-grade gliomas stratified by age, gender, tumor grade, and seizures status in TCGA database.](/cms/asset/d414002c-d275-40cf-9d60-585ea7836967/dijg_a_12168402_f0003_c.jpg)
Figure 4 ROC of the five-gene signature for predicting the 1-, 3- and 5-year survival of 272 patients with lower-grade gliomas in TCGA database.
![Figure 4 ROC of the five-gene signature for predicting the 1-, 3- and 5-year survival of 272 patients with lower-grade gliomas in TCGA database.](/cms/asset/6a5c610a-7b1c-45a5-8c79-bc6c3a8a4226/dijg_a_12168402_f0004_c.jpg)
Figure 5 Kaplan–Meier curves of the five-gene signature for high- (n = 136) and low-risk (n = 136) patients with lower-grade gliomas stratified by age, gender, tumor grade, and seizures status in CGGA database.
![Figure 5 Kaplan–Meier curves of the five-gene signature for high- (n = 136) and low-risk (n = 136) patients with lower-grade gliomas stratified by age, gender, tumor grade, and seizures status in CGGA database.](/cms/asset/ade814f6-c311-4a18-9654-625e9b178ceb/dijg_a_12168402_f0005_c.jpg)
Figure 6 ROC of the five-gene signature for predicting the 1-, 3- and 5-year survival of 157 patients with lower-grade gliomas in CGGA database.
![Figure 6 ROC of the five-gene signature for predicting the 1-, 3- and 5-year survival of 157 patients with lower-grade gliomas in CGGA database.](/cms/asset/143daa55-4454-4276-8c43-46280c28b314/dijg_a_12168402_f0006_c.jpg)
Table 2 Cox Regression Analysis of Clinical Pathologic Features for OS in TGGA Cohort
Figure 7 Functional enrichment analysis of DEGs between different seizures presentations in lower-grade gliomas. (A) GO enrichment analysis of DEGs between different seizures presentations in lower-grade gliomas. (B) KEGG pathways of DEGs between different seizures presentations in lower-grade gliomas.
![Figure 7 Functional enrichment analysis of DEGs between different seizures presentations in lower-grade gliomas. (A) GO enrichment analysis of DEGs between different seizures presentations in lower-grade gliomas. (B) KEGG pathways of DEGs between different seizures presentations in lower-grade gliomas.](/cms/asset/d66c466b-1a37-47fd-8495-b57f7dc5d6fc/dijg_a_12168402_f0007_c.jpg)