Plasma Levels of Homocysteine is Associated with Liver Fibrosis in Health Check-Up Population

Figures & data

Table 1 Basic Characteristics and Laboratory Data of the Study Population

Factors	F0 (n=556)	F1(n=553)	F2(n=228)	F3(n=164)	F4(n=81)	P
Age (years)	45.45±10.73	47.89±10.45	49.25±10.81	50.17±12.29	53.19±11.14	<0.001
Male sex [n (%)]	397(71.4)	436(78.8)	193(84.6)	146(89.0)	75(92.6)	<0.001
BMI (kg/m^2)	23.52±2.92	25.27±3.04	26.92±3.33	27.29±3.44	28.41±3.42	<0.001
Hcy (umol/L)	12.54±4.07	13.41±4.14	17.70±4.51	18.93±4.83	19.49±4.60	<0.001
ALT (IU/L)	25.99±6.42	25.74±6.99	26.45±6.63	28.62±6.81	29.38±6.74	<0.001
AST (IU/L)	28.76±6.97	27.65±7.12	27.69±7.21	28.05±7.90	28.93±7.03	0.072
GGT (IU/L)	31.58±9.63	32.89±9.74	32.64±9.58	33.78±9.89	34.70±9.23	0.012
TG (mmol/L)	1.66±0.69	1.74±0.65	1.77±0.72	1.84±0.74	1.87±0.74	0.006
TBil (umol/L)	18.63±5.16	18.09±5.05	17.69±5.67	17.57±5.23	17.87±5.58	0.070
TC (mmol/L)	5.04±0.98	5.12±0.98	5.13±1.04	5.21±1.05	5.17±1.18	0.342
HDL-C(mmol/L)	1.21±0.26	1.21±0.25	1.19±0.27	1.17±0.25	1.17±0.26	0.169
LDL-C(mmol/L)	2.82±0.67	3.01±0.68	3.28±0.69	3.45±0.75	3.68±0.73	<0.001
FBS (mmol/L)	5.46±0.78	5.46±0.85	5.56±0.86	5.72±0.81	5.75±0.90	<0.001
PLT (×10^9/L)	238.32±48.67	232.33±45.31	220.21±46.53	200.15±52.53	184.84±45.97	<0.001

Table 2 Spearman Correlation Analysis Between the LSM Values and Clinical Parameters

Factors	Correlation Coefficient (r)	P
Age	0.309	<0.001
Male sex ratio	0.162	<0.001
BMI	0.548	<0.001
Hcy	0.552	<0.001
ALT	0.110	<0.001
AST	0.003	0.898
GGT	0.026	0.303
TG	0.044	0.080
TBil	−0.039	0.122
TC	0.048	0.055
HDL-C	−0.025	0.316
LDL-C	0.418	<0.001
FBS	0.026	0.303
PLT	−0.258	<0.001

Table 3 Spearman Correlation Analysis Between Plasma Hcy Concentration and Serum Biomarkers of Liver Fibrosis

Factors	Correlation Coefficient (r)	P
AST/ALT	0.219	<0.001
APRI	0.351	<0.001
FIB-4	0.479	<0.001

Table 4 Multiple Linear Regression Analysis Between LSM and Age, BMI, Hcy, ALT, LDL-C, and PLT

N-Dependent Variables	Estimated Regression Coefficient	Standardized Regression Coefficient	t	P
(Constant)	−3.284		−5.430	<0.001
Age	0.014	0.052	2.366	0.018
BMI	0.256	0.287	12.745	<0.001
Hcy	0.163	0.263	11.676	<0.001
ALT	0.036	0.080	4.133	<0.001
LDL-C	0.788	0.187	8.739	<0.001
PLT	−0.009	−0.143	−6.986	<0.001