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International Journal of General Medicine Volume 14, 2021 - Issue
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Original Research

Different Cutoff Values for Increased Nuchal Translucency in First-Trimester Screening to Predict Fetal Chromosomal Abnormalities

Linjuan SuFujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China
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Xiaoqing WuFujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-2605-2362
ORCID Icon,
Na LinFujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China
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Xiaorui XieFujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China
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Meiying CaiFujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-7431-2475
ORCID Icon,
Meiying WangFujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China
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Lin ZhengFujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-6178-1558
ORCID Icon &
Liangpu XuFujian Provincial Key Laboratory for Prenatal Diagnosis and Birth Defect, Medical Genetic Diagnosis and Therapy Center, Fujian Provincial Maternity and Children’s Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of ChinaCorrespondence[email protected] [email protected]
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Pages 8437-8443 | Published online: 18 Nov 2021

Figures & data

Table 1 Clinical Characteristics of the Study Population

Table 2 Performance of NT for Detecting All Karyotype Aneuploidies

Figure 1 Effectiveness of screening for chromosomal aberrations using different cutoff values for fetal nuchal translucency (NT). ROC curve of NT: NT ≥2.5 mm: area under the curve (AUC) = 0.619, 95% confidence interval (CI) = 0.571–0.667, P < 0.0001. NT ≥95th: AUC = 0.624, 95% CI = 0.575–0.672, P < 0.0001. NT ≥99th: AUC = 0.610, 95% CI = 0.560–0.660, P < 0.0001. NT ≥3.0 mm: AUC = 0.616, 95% CI = 0.566–0.666, P < 0.0001. NT ≥3.5 mm: AUC = 0.599, 95% CI = 0.548–0.651, P < 0.0001.

Figure 1 Effectiveness of screening for chromosomal aberrations using different cutoff values for fetal nuchal translucency (NT). ROC curve of NT: NT ≥2.5 mm: area under the curve (AUC) = 0.619, 95% confidence interval (CI) = 0.571–0.667, P < 0.0001. NT ≥95th: AUC = 0.624, 95% CI = 0.575–0.672, P < 0.0001. NT ≥99th: AUC = 0.610, 95% CI = 0.560–0.660, P < 0.0001. NT ≥3.0 mm: AUC = 0.616, 95% CI = 0.566–0.666, P < 0.0001. NT ≥3.5 mm: AUC = 0.599, 95% CI = 0.548–0.651, P < 0.0001.

Table 3 Performance of NT for Detection of Trisomy 21

Figure 2 Effectiveness of screening for trisomy 21 using diffident cutoff values of fetal nuchal translucency (NT). ROC curve of NT: NT ≥2.5 mm: area under the curve (AUC) = 0.692, 95% confidence interval (CI) = 0.630–0.755, P < 0.0001. NT ≥95th: AUC = 0.700, 95% CI = 0.637–0.755, P < 0.0001. NT ≥ 99th: AUC = 0.682, 95% CI = 0.614–0.751, P < 0.0001. NT ≥3.0 mm: AUC = 0.679, 95% CI = 0.610–0.748, P < 0.0001. NT ≥3.5 mm: AUC = 0.642, 95% CI = 0.569–0.714, P < 0.0001.

Figure 2 Effectiveness of screening for trisomy 21 using diffident cutoff values of fetal nuchal translucency (NT). ROC curve of NT: NT ≥2.5 mm: area under the curve (AUC) = 0.692, 95% confidence interval (CI) = 0.630–0.755, P < 0.0001. NT ≥95th: AUC = 0.700, 95% CI = 0.637–0.755, P < 0.0001. NT ≥ 99th: AUC = 0.682, 95% CI = 0.614–0.751, P < 0.0001. NT ≥3.0 mm: AUC = 0.679, 95% CI = 0.610–0.748, P < 0.0001. NT ≥3.5 mm: AUC = 0.642, 95% CI = 0.569–0.714, P < 0.0001.

Table 4 Criteria of Increased NT in Different Countries

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