Association of the ENPP1/ENTPD1 Polymorphisms in Hemodialysis Patients

Figures & data

Figure 1 ATP-ADP-AMP-adenosine axis.

Figure 2 The flow chart of subjects included and exclude.

Table 1 The Distributions of DM/Non-DM, HBP/Non-HBP, NS/Non-NS and AD/Non-AD with Different rs1044498/rs6584026 Genotypes and Their Genotype Frequencies

		rs1044498		P	rs6584026		P
		A/A	A/C		C/C	C/T
Age(Year)	57.08±15.21	56.49±15.59	58.95±13.77	0.031	55.99±15.80	59.32±13.70	0.063
Sex (Male/Female)	414/129	228/186	78/51	0.310	210/156	96/81	0.519
HD-age(Year)	3.97±3.01	3.99±3.02	3.91±3.00	0.777	3.83±2.84	4.26±3.32	0.369
Calcium	2.19±0.28	2.19±0.28	2.17±0.27	0.424	2.18±0.29	2.20±0.25	0.507
Phosphate	1.69±0.59	1.71±0.59	1.63±0.63	0.187	1.71±0.58	1.66±0.62	0.411
Serum creatinine	716.59±294.13	724.41±303.33	691.51±261.33	0.577	728.75±288.68	691.46±304.00	0.166
Urine nitrogen	18.94±9.67	19.20±9.79	18.10±9.23	0.256	19.75±9.62	17.27±9.57	0.005
Albumin	37.71±5.82	37.73±6.08	37.65±4.90	0.620	37.20±5.73	38.76±5.86	0.003
Globulin	50.57±19.61	49.99±19.61	52.44±19.54	0.214	52.30±19.05	51.14±20.74	0.164
Alkaline phosphatase	156.69±212.36	155.48±220.45	160.58±184.28	0.812	143.58±202.49	183.80±229.40	0.038
Parathyroid Hormone	445.82±563.04	443.92±594.75	451.91±446.94	0.888	427.41±551.28	483.88±585.60	0.273
Hemoglobin	103.4±23.67	103.89±23.34	101.84±24.69	0.390	102.05±23.71	106.20±23.36	0.055
High-density lipoprotein	1.14±0.39	1.14±0.37	1.15±0.45	0.767	1.14±0.37	1.13±0.42	0.707
Low-density lipoprotein	2.30±0.79	2.28±0.75	2.32±0.90	0.963	2.25±0.73	2.37±0.89	0.273
Lipoprotein α	403.88±410.06	351.96±323.21	570.49±581.03	0.000	372.95±358.14	467.73±495.21	0.031
Cholesterol	3.90±1.14	3.90±1.02	3.92±1.49	0.156	3.72±1.04	4.27±1.26	0.000
Triglyceride	1.72±1.35	1.74±1.26	1.64±1.61	0.470	1.58±1.21	2.01±1.57	0.000
ApolipoproteinA1	1.19±0.27	1.20±0.25	1.17±0.33	0.261	1.18±0.25	1.21±0.32	0.563
ApolipoproteinB	0.80±0.27	0.80±0.24	0.81±0.34	0.231	0.76±0.24	0.88±0.30	0.000
ApoB/A1	0.70±0.30	0.69±0.24	0.76±0.43	0.806	0.67±0.24	0.78±0.38	0.000

Notes: Except the data for gender, data are expressed as mean ± SD. Student’s t-test and analysis of variance were used to analyze continuous variables. The rank sum test was performed while the continuous variables were uneven. P<0.05 shows values are statistical significantly in bold.

Table 2 The Clinical Characteristics of Subjects with Different Genotypes (rs1044498/rs6584026)

	rs1044498		P	rs6584026		P
	A/A	A/C		C/C	C/T
DM	102	36	0.488	84	54	0.059
Non-DM	312	93		282	123
HBP	102	27	0.410	84	45	0.521
Non-HBP	312	102		282	132
NS	123	39	0.913	132	30	0.000
Non-NS	291	90		234	147
AD	15	3	0.472	18	0	0.003
Non-AD	399	126		348	177
Genotype frequency	414	129	0.238	366	177	0.328

Notes: Counts were analyzed using the chi-square test. P<0.05 shows values are statistical significantly in bold.

Abbreviations: DM, diabetes mellitus; HBP, high blood pressure; NS, nephritis; AD, autoimmune diseases; SLE, systemic lupus erythematosus; ANCA-GN, ANCA-associated glomerulonephritis.

Table 3 Association of rs6584026 Genotype with Some Characteristics

	OR(95% CI)	P
Urine nitrogen	0.9817(0.960–1.003)	0.278
Albumin	1.087(1.046–1.130)	0.000
Alkaline phosphatase	1.001(1.000–1.002)	0.043
Lipoprotein α	1.001(1.000–1.001)	0.045
Cholesterol	1.633(1.160–2.300)	0.005
Triglyceride	1.018(0.865–1.198)	0.828
Apo B/A1	6.275(2.147–18.345)	0.001
NS and non-NS	0.298(0.182–0.491)	0.000

Notes: The rs6584026 genotype was estimated by binary logistic regression analysis with adjusted confounders, sex, age and HD-age. P<0.05 shows values are statistical significantly in bold.

Abbreviations: OR, odds ratio; CI, confidence interval; NS, nephritis.