Epidemiological, Clinical, Laboratorial and CT Imaging Features of Hospitalized Patients with Initially Negative Detection of SARS-CoV-2 in China

Figures & data

Table 1 Basic Characteristic

	ALL
Gender
Male	5
Female	4
Age	33.22±18.14
1~18	1
18–30	4
31–60	3
60+	1
Smoking History	None
Exposure History
Wuhan Exposure	7
COVID-19 Patient Exposure	5
Unknown	1
Means Days Between Symptoms Onset And Initial Negative Detection	2.44±2.01
Means Days Between Symptoms Onset And Initial Positive Detection	6.22±4.6
Duration Of Positive Detection From Upper Respiratory Samples	5.56±6.06
Duration Of Positive Detection From Gastrointestinal Samples	6.56±7.11
Mean Number Of Detection Before Positive	1.44±1.01
Previous Medical History
Diabetes	0
Hypertension	1
Cancer	0
Gastrointestinal Disease	3
Eczema	1
Average Number Of CT Scan	3.78
Interval Between The Adjacent Scans	4.4
The Mulbsta Score	7±3.46

Figure 1 Timeline of symptoms onset and RT-PCR. Light green represents symptoms, yellow represents positive RT-PCR detection from respiratory samples, red represents positive RT-PCR detection from gastrointestinal samples, black represents negative RT-PCR detection.

Table 2 Clinical Symptoms, Laboratory Findings and Oxygen Support

	Stage 1	Stage 2	Stage 3
Symptoms
Fever	6	0	0
Fatigue	0	0	0
Cough	5	3	1
Expectoration	0	0	0
Chest Pain	0	0	0
Chest Tightness	2	2	0
Dyspnea	0	1	0
Vomiting	0	0	0
Poor Appetite	0	0	0
Diarrhea	1	0	0
Nausea	1	0	0
Laboratory-Investigation
White Blood Cell Count	5.46±1.99	5.45±1.55	6.15±2.53
Neutrophil Count	3.11±1.48	2.94±1.27	3.57±2.08
Lymphocyte Count	2.01±1.38	1.94±0.9	1.84±0.58
Neutrophil/Lymphocyte	1.55	1.52	1.94
Eosinophil Count	0.08±0.1	0.11±0.11	0.4±0.63
C-Reactive Protein	7.86±13.29	11.88±24.47	1.1±0.49
Alanine Aminotransferase	22.19±14.21	19.12±11.49	34.61±44.32
Aspartate Aminotransferase	19.31±7.59	19.57±9.59	26.14±23.65
Alt/Ast	1.15	0.98	1.32
Lactate	1.55±0.49	1.31±0.24	1.71±0.52
Serum Albumin	38.93±2.47	40.49±2.76	39.66±2.82
Seroglobulin	28.94±3.33	29.39±3.52	30.39±4.95
Alb/Glb	1.35	1.38	1.31
Serum Creatinine	52.54±17.27	59.46±17.46	64.66±9.21
Creatine Kinase	64.57±18.3	58.11±14.79	56.43±22.11
Partial Arterial Oxygen Pressure	105.7±8.49	108.89±20.84	120.27±29.41
Oxygen Support
Noninvasive Ventilation	0	0	0
High-Flow Nasal Cannula (HFNC)	0	0	1
Nasal Tube	0	1	1
Room Air	9	8	7

Figure 2 Timeline charts illustrate the mean laboratory parameters in various stages. On the left primary vertical axis is the quantitative variable and on the right secondary axis is the ratio. (A) Neutrophil Count, Lymphocyte Count and ratio of them among each stage. (B) ALT, AST and ratio of them among each stage. (C) Alb, Glb and ratio of them among each stage.

Table 3 CT Scan Features

	Stage 1	Stage 2	Stage 3
Number of Involved Lobes
0	2	2	2
1	2	2	2
2	1	1	1
3	0	1	0
4	0	0	1
5	3	2	2
Frequency of Lobes Abnormalities
Left Upper	4	3	3
Left Lower	5	6	6
Right Upper	3	2	3
Right Middle	3	2	2
Right Lower	4	4	4
Only Left	2	2	2
Only Right	0	0	0
Bilateral Multilobe	3	4	4
Distribution of Involved Lobes
Central	0	1	1
Peripheral	5	5	5
Random	1	0	0
Diffuse	0	0	0
GGO	5	5	4
Crazy-Paving Pattern	0	1	2
Consolidation	0	1	1
Effusion	0	0	2
Absorbed	0	0	3