Nomogram for Predicting Overall Survival in Acral Lentiginous Melanoma: A Population‐based Study

Figures & data

Figure 1 Flowchart of the selection of the studies in the meta-analysis.

Table 1 Baseline Characteristics of Patients with ALM

Variable	Training Cohort	Validation Cohort
Number of Patients n (%)	1249 (70)	536 (30)
Age at diagnosis	65 (54–76)	66 (54–76)
Sex n (%)
Male	605 (48.4)	250 (46.6)
Female	644 (51.6)	286 (53.4)
Race n (%)
White	1034 (83.8)	453 (84.5)
Black	111 (8.9)	38 (7.1)
Other	104 (8.3)	45 (8.4)
Marital status n (%)
Married	770 (61.6)	337 (62.9)
Unmarried	198 (15.9)	81 (15.1)
DSW	281 (22.5)	118 (22.0)
AJCC stage n (%)
I	569 (45.6)	237 (44.2)
II	364 (29.1)	164 (30.6)
III	279 (22.3)	125 (23.3)
IV	37 (3.0)	10 (1.9)
SEER stage n (%)
Localized	854 (68.4)	361 (67.4)
Regional	334 (26.7)	154 (28.7)
Distant	61 (4.9)	21 (3.9)
Site n (%)
Head and neck	15 (1.2)	7 (1.3)
Trunk	13 (1.0)	7 (1.3)
Upper limb	227 (18.2)	95 (17.7)
Lower limb	989 (79.2)	423 (78.9)
Others	5 (0.4)	4 (0.7)
Laterality n (%)
Left	620 (49.6)	268 (50.0)
Right	624 (50.0)	262 (48.9)
Not a paired site	5 (0.4)	6 (0.7)
Surgery n (%)
Yes	1232 (98.6)	525 (97.9)
No	17 (1.4)	11 (2.1)

Table 2 Variables Selected by Multivariate Cox Regression Analysis (Training Cohort)

Variable	Multivariate Analysis
	Hazard Ratio (HR)	95% Confidence Interval (95% CI)	P‐value
Age at diagnosis	1.044	1.036–1.053	<0.001
Sex
Male		Reference
Female	0.579	0.474–0.707	<0.001
Race
White	Reference
Black	1.590	1.182–2.140	0.002
Other	0.975	0.696–1.366	0.883
Marital status
Married	Reference
Unmarried	1.421	1.032–1.955	0.031
DSW	1.374	1.098–1.720	0.006
AJCC stage
I	Reference
II	2.246	1.723–2.927	<0.001
III	4.013	2.565–6.279	<0.001
IV	4.988	2.421–10.276	<0.001
SEER stage
Localized	Reference
Regional	1.015	0.696–1.480	0.939
Distant	2.351	1.275–4.335	0.006
Surgery
Yes	Reference
No	3.533	1.725–7.238	<0.001

Figure 2 Nomogram of ALM.

Figure 3 Receiver operating characteristic curves. (A and B) represent the training cohort and validation cohort of the nomogram, while (C and D) represent the training cohort and validation cohort of the AJCC staging system, respectively.

Figure 4 Calibration diagram. (A, C, and E) represent the standard curves of 3-, 5-, and 8-year OS in the training cohort, while (B, D, and F) represent the standard curves of 3-, 5-, and 8-year OS in the validation cohort, respectively.

Figure 5 DCA. (A, C, and E) represent the DCA of 3-, 5-, and 8-year OS in the training cohort, while (B, D, and F) represent the DCA of 3-, 5-, and 8-year OS in the validation cohort, respectively.