Prognosis and Survival Analysis of 922,317 Lung Cancer Patients from the US Based on the Most Recent Data from the SEER Database (April 15, 2021)

Figures & data

Table 1 Basic Characteristics of Patients and Survival Analysis According to Different Factors

	Number of Patients	Percentage of Total Patients (%)	3-Year Survival Rate (%)	Probability Density	5-Year Survival Rate (%)	Probability Density	10-Year Survival Rate (%)	Probability Density	Median Survival Time (Months)	Standard Error	95.0%, CI		Mean Survival Time (Months)	Standard Error	95.0%, CI
											Lower	Upper			Lower	Upper
Total	9,22,317	100	19	0.003	14	0.002	8	0.001	9	0.021	8.959	9.041	32.793	0.066	32.663	32.922
Sex
Female	4,32,762	46.9	23	0.004	18	0.002	10	0.001	11	0.039	10.923	11.077	38.805	0.107	38.595	39.015
Male	4,89,555	53.1	16	0.003	12	0.002	6	0.001	8	0.025	7.952	8.048	27.522	0.08	27.365	27.68
Age
< 45 years	15,701	1.7	32	0.003	28	0.001	24	0.001	16	0.284	15.443	16.557	67.082	0.763	65.586	68.579
45–54 years	74,518	8.1	24	0.003	20	0.001	15	0.001	12	0.088	11.827	12.173	46.308	0.29	45.74	46.876
55–64 years	1,98,128	21.5	23	0.003	18	0.002	12	0.001	11	0.051	10.9	11.1	41.111	0.165	40.788	41.433
65–74 years	3,00,953	32.6	21	0.004	16	0.002	8	0.001	11	0.041	10.92	11.08	34.554	0.115	34.33	34.779
75–84 years	2,54,341	27.6	15	0.003	10	0.002	3	0.001	7	0.034	6.933	7.067	23.075	0.087	22.904	23.246
≥ 85 years	78,676	8.5	7	0.002	4	0.001	1	0	3	0.034	2.933	3.067	12.349	0.091	12.171	12.527
Race
White	7,65,078	83	19	0.003	14	0.002	8	0.001	9	0.023	8.955	9.045	32.726	0.072	32.585	32.867
Black	1,00,450	10.9	17	0.003	12	0.002	7	0.001	9	0.06	8.882	9.118	29.497	0.191	29.124	29.871
Asian and others (a)	56,789	6.2	23	0.004	17	0.002	11	0.001	12	0.124	11.757	12.243	40.002	0.32	39.375	40.629
Origin recode NHIA
Non-Spanish-Hispanic-Latino	8,72,814	94.6	19	0.003	14	0.002	8	0.001	9	0.021	8.958	9.042	32.686	0.068	32.553	32.818
Spanish-Hispanic-Latino	49,503	5.4	20	0.003	15	0.002	9	0.001	9	0.094	8.816	9.184	35.001	0.321	34.373	35.629
Median household income inflation adj to 2019
< $35,000	19,711	2.1	15	0.003	11	0.001	5	0.001	7	0.111	6.783	7.217	25.872	0.405	25.079	26.665
$35,000-$44,999	76,395	8.3	16	0.003	12	0.002	6	0.001	8	0.064	7.875	8.125	28.092	0.219	27.663	28.521
$45,000-$54,999	1,52,943	16.6	17	0.003	13	0.002	6	0.001	8	0.049	7.905	8.095	28.94	0.151	28.645	29.235
$55,000-$64,999	2,18,082	23.6	18	0.003	14	0.002	8	0.001	9	0.042	8.917	9.083	31.782	0.132	31.522	32.041
$65,000-$74,999	1,95,430	21.2	20	0.003	15	0.002	8	0.001	9	0.05	8.901	9.099	33.927	0.147	33.639	34.215
$75,000+	2,59,669	28.2	22	0.004	16	0.002	9	0.001	11	0.045	10.911	11.089	36.832	0.133	36.571	37.92
Others (b)	87	0	13	0.01	10	0.002	0	0	14	2.287	9.517	18.483	25.118	3.734	17.799	32.438
Rural-Urban Continuum Code
Counties in metropolitan areas greater than 1 million population	5,24,354	56.9	20	0.003	15	0.002	9	0.001	10	0.031	9.939	10.061	34.716	0.091	34.537	34.895
Counties in metropolitan areas of 250,000 to 1 million population	1,76,075	19.1	19	0.003	14	0.002	8	0.001	9	0.047	8.907	9.093	32.469	0.151	32.172	32.765
Counties in metropolitan areas of less than 250 thousand population	81,081	8.8	18	0.003	13	0.002	7	0.001	9	0.068	8.867	9.133	29.798	0.205	29.396	30.199
Nonmetropolitan counties adjacent to a metropolitan area	80,876	8.8	16	0.003	12	0.002	6	0.001	8	0.064	7.875	8.125	28.298	0.2	27.906	28.689
Nonmetropolitan counties not adjacent to a metropolitan area	58,676	6.4	16	0.003	11	0.002	6	0.001	8	0.07	7.863	8.137	27.212	0.231	26.76	27.664
Others (c)	1255	0.1	14	0.003	11	0.001	5	0	9	0.475	8.069	9.931	25.974	1.478	23.078	28.87
Primary site
Right upper lobe	2,44,392	26.5	23	0.004	17	0.002	10	0.001	12	0.052	11.898	12.102	38.607	0.136	38.341	38.873
Right middle lobe	38,374	4.2	26	0.004	20	0.002	12	0.001	13	0.151	12.705	13.295	43.843	0.381	43.097	44.589
Right lower lobe	1,23,735	13.4	22	0.004	17	0.002	9	0.001	11	0.072	10.859	11.141	37.296	0.191	36.922	37.671
Left upper lobe	1,95,234	21.2	22	0.004	16	0.002	9	0.001	11	0.053	10.896	11.104	36.099	0.149	35.807	36.39
Left lower lobe	99,281	10.8	23	0.004	18	0.002	10	0.001	11	0.078	10.848	11.152	37.904	0.221	37.471	38.337
Main bronchus	43,133	4.7	8	0.002	6	0.001	4	0	5	0.055	4.892	5.108	17.515	0.211	17.102	17.927
Over lapping lesion of lung	10,731	1.2	17	0.003	13	0.001	7	0.001	7	0.164	6.678	7.322	28.642	0.562	27.541	29.743
Lung, NOS	1,64,777	17.9	7	0.002	4	0.001	2	0	4	0.026	3.949	4.051	13.678	0.092	13.497	13.859
Others (d)	2660	0.3	8	0.002	5	0.001	2	0.001	5	0.22	4.569	5.431	15.838	0.668	14.527	17.148
Histologic type (ICD-O-3)
Neoplasia, NAS	67,189	7.3	6	0.002	4	0.001	2	0	2	0.027	1.946	2.054	12.431	0.156	12.126	12.736
Epithelial Neoplasms, NAS	2,94,702	32	9	0.002	6	0.001	3	0	6	0.024	5.954	6.046	17.939	0.074	17.794	18.084
Squamous cell neoplasms	1,79,942	19.5	20	0.004	15	0.002	7	0.001	11	0.055	10.893	11.107	32.733	0.136	32.468	32.999
Adenoma and adenocarcinomas	3,47,366	37.7	28	0.004	22	0.002	13	0.001	15	0.061	14.88	15.12	46.591	0.132	46.333	46.849
Cystic, mucinous and serous neoplasms	12,070	1.3	29	0.004	23	0.002	14	0.001	15	0.377	14.261	15.739	48.995	0.762	47.5	50.489
Acinous cell neoplasm	7044	0.8	67	0.005	55	0.004	34	0.002	86	2.44	81.217	90.783	102.005	1.719	98.636	105.373
Complex epithelial neoplasms	10,523	1.1	26	0.004	20	0.002	11	0.001	14	0.319	13.375	14.625	42.256	0.671	40.94	43.571
Others (e)	3481	0.4	30	0.003	26	0.002	19	0.001	12	0.566	10.891	13.109	56.854	1.541	53.834	59.874
Year of diagnosis
2000	48,893	5.3	15	0.003	11	0.001	6	0.001	8	0.071	7.862	8.138	27.008	0.228	26.56	27.455
2001	49,520	5.37	15	0.003	11	0.001	6	0.001	8	0.07	7.863	8.137	26.954	0.223	26.517	27.391
2002	49,658	5.38	15	0.003	11	0.001	6	0.001	8	0.07	7.863	8.137	26.672	0.216	26.249	27.095
2003	50,123	5.43	16	0.003	12	0.001	7	0.001	8	0.075	7.854	8.146	26.974	0.211	26.56	27.389
2004	49,890	5.41	16	0.003	12	0.002	7	0.001	8	0.076	7.851	8.149	27.146	0.206	26.741	27.55
2005	50,749	5.5	17	0.003	13	0.002	7	0.001	8	0.082	7.839	8.161	27.358	0.2	26.966	27.751
2006	51,223	5.55	18	0.003	13	0.002	7	0.001	9	0.085	8.833	9.167	27.555	0.194	27.175	27.935
2007	51,598	5.59	18	0.003	14	0.002	7	0.001	9	0.089	8.826	9.174	27.275	0.184	26.915	27.636
2008	51,869	5.62	19	0.003	14	0.002	8	0.001	9	0.086	8.831	9.169	26.995	0.175	26.653	27.338
2009	52,587	5.7	19	0.003	14	0.002	N/A	N/A	9	0.087	8.829	9.171	26.466	0.164	26.145	26.787
2010	51,355	5.57	20	0.003	15	0.002	N/A	N/A	9	0.087	8.829	9.171	25.787	0.155	25.483	26.091
2011	50,918	5.52	21	0.003	15	0.002	N/A	N/A	10	0.101	9.803	10.197	25.461	0.145	25.177	25.745
2012	51,591	5.59	20	0.003	15	0.002	N/A	N/A	10	0.099	9.806	10.194	23.689	0.129	23.435	23.943
2013	51,787	5.61	21	0.003	16	0.002	N/A	N/A	10	0.102	9.8	10.2	22.55	0.115	22.324	22.776
2014	52,469	5.69	23	0.004	N/A	N/A	N/A	N/A	11	0.104	10.796	11.204	21.215	0.1	21.019	21.411
2015	52,702	5.71	24	0.004	N/A	N/A	N/A	N/A	11	0.124	10.757	11.243	19.492	0.083	19.33	19.654
2016	52,642	5.71	N/A	N/A	N/A	N/A	N/A	N/A	12	0.135	11.736	12.264	16.725	0.064	16.601	16.85
2017	52,743	5.72	N/A	N/A	N/A	N/A	N/A	N/A	13	0.152	12.703	13.297	12.966	0.042	12.883	13.05
Summary stage
Distant	4,80,617	52.1	5	0.002	3	0.001	2	0	4	0.013	3.974	4.026	12.89.	0.047	12.798	12.982
Localized	1,69,955	18.4	51	0.006	40	0.004	24	0.002	49	0.258	48.494	49.506	78.295	0.22	77.863	78.726
Regional	2,03,809	22.1	28	0.005	21	0.003	11	0.001	18	0.076	17.851	18.149	45.042	0.154	44.739	45.344
Unknown/unstaged	67,936	7.4	10	0.003	7	0.001	3	0	6	0.07	5.863	6.137	19.61	0.186	19.245	19.976

Notes: (a) included Asian or Pacific Islander and American Indian/Alaska Native. (b) Others included unknown/missing/no match/Not 1990–2018. (c) Others included Unknown/missing/no match (Alaska or Hawaii - Entire State) and Unknown/missing/no match/Not 1990–2018. (d) Others included Only one side - side unspecified, Bilateral, single primary and Paired site, but no information concerning laterality. (e) Others included all the histological types of lung cancer except the above seven types.

Table 2 Overall Comparison and Pairwise Comparison of Each Group in Kaplan–Meier Survival Analysis

Comparison Type	Comparative Factor	Log Rank (Mantel-Cox)		Breslow (Generalized Wilcoxon)		Tarone-Ware
		Chi Square	Sig.	Chi Square	Sig.	Chi Square	Sig.
Overall comparison	Sex	3,119.588	0.000	2,577.577	0.000	2,934.977	0.000
	Age	36,486.760	0.000	33,627.846	0.000	34,681.780	0.000
	Race	1,300.355	0.000	1,210.942	0.000	1,311.907	0.000
	Origin recode NHIA	10.506	0.001	0.624	0.429	0.323	0.570
	Median household income inflation adj to 2019	3,119.588	0.000	2,577.577	0.000	2,934.977	0.000
	Rural-Urban Continuum Code	1,952.945	0.000	1,397.391	0.000	1,696.331	0.000
	Primary site	56,749.667	0.000	57,432.600	0.000	59,443.510	0.000
	Histologic type (ICD-O-3)	82,913.123	0.000	79,928.300	0.000	84,548.100	0.000
	Year of diagnosis	7,532.042	0.000	5,692.115	0.000	6,834.910	0.000
	Summary stage	240,670.146	0.000	219,186.158	0.000	239,656.003	0.000
Pairwise comparison	Sex
	Female vs Male	9,473.321	0.000	7,344.132	0.000	8,697.481	0.000
	Age
	< 45 years vs 45–54 years	658.146	0.000	451.420	0.000	535.237	0.000
	< 45 years vs 55–64 years	1,186.997	0.000	755.752	0.000	891.847	0.000
	< 45 years vs 65–74 years	2,134.621	0.000	1,209.475	0.000	1,450.388	0.000
	< 45 years vs 75–84 years	5,280.355	0.000	3,281.758	0.000	3,847.412	0.000
	< 45 years vs ≥ 85 years	9,405.387	0.000	7,374.587	0.000	8,275.701	0.000
	45–54 years vs 55–64 years	168.537	0.000	131.890	0.000	125.492	0.000
	45–54 years vs 65–74 years	1,135.723	0.000	766.972	0.000	783.114	0.000
	45–54 years vs 75–84 years	7,332.664	0.000	5,949.599	0.000	6,199.769	0.000
	45–54 years vs≥ 85 years	16,522.957	0.000	16,185.395	0.000	16,484.200	0.000
	55–64 years vs 65–74 years	734.202	0.000	495.365	0.000	520.272	0.000
	55–64 years vs 75–84 years	9,978.407	0.000	8,503.476	0.000	8,906.353	0.000
	55–64 years vs≥ 85 years	21,880.320	0.000	21,656.557	0.000	22,006.761	0.000
	65–74 years vs 75–84 years	7,052.078	0.000	6,213.807	0.000	6,581.952	0.000
	65–74 years vs≥ 85 years	19,673.925	0.000	19,042.105	0.000	19,640.948	0.000
	75–84 years vs ≥ 85 years	6,915.700	0.000	6,358.064	0.000	6,757.770	0.000
	Race
	White vs Black	278.487	0.000	106.505	0.000	189.853	0.000
	White vs Asian and other races	918.554	0.000	1,032.227	0.000	1,028.928	0.000
	Black vs Asian and other races	1,325.507	0.000	1,162.642	0.000	1,310.095	0.000
	Origin recode NHIA
	Non-Spanish-Hispanic-Latino vs Spanish-Hispanic-Latino	10.506	0.001	0.624	0.429	0.323	0.570
	Median household income inflation adj to 2019
	< $35,000 vs $35,000-$44,999	42.062	0.000	33.672	0.000	40.737	0.000
	< $35,000 vs $45,000-$54,999	85.564	0.000	68.062	0.000	81.767	0.000
	< $35,000 vs $55,000-$64,999	230.631	0.000	172.090	0.000	206.247	0.000
	< $35,000 vs $65,000-$74,999	431.627	0.000	337.420	0.000	396.074	0.000
	< $35,000 vs $75,000+	811.362	0.000	684.642	0.000	774.900	0.000
	< $35,000 vs Others	2.197	0.138	4.895	0.027	4.144	0.042
	$35,000-$44,999 vs $45,000-$54,999	16.965	0.000	12.927	0.000	15.542	0.000
	$35,000-$44,999 vs $55,000-$64,999	214.341	0.000	144.686	0.000	176.486	0.000
	$35,000-$44,999 vs $65,000-$74,999	588.760	0.000	440.256	0.000	520.033	0.000
	$35,000-$44,999 vs $75,000+	1,464.530	0.000	1,219.404	0.000	1,378.889	0.000
	$35,000-$44,999 vs Others	1.005	0.316	3.174	0.075	2.395	0.122
	$45,000-$54,999 vs $55,000-$64,999	176.365	0.000	107.494	0.000	134.260	0.000
	$45,000-$54,999 vs $65,000-$74,999	636.716	0.000	461.262	0.000	549.033	0.000
	$45,000-$54,999 vs $75,000+	1,882.057	0.000	1,547.162	0.000	1,755.248	0.000
	$45,000-$54,999 vs Others	0.699	0.403	2.703	0.100	1.938	0.164
	$55,000-$64,999 vs $65,000-$74,999	177.901	0.000	155.032	0.000	175.937	0.000
	$55,000-$64,999 vs $75,000+	1,064.955	0.000	995.599	0.000	1,088.148	0.000
	$55,000-$64,999 vs Others	0.219	0.640	1.752	0.186	1.068	0.301
	$65,000-$74,999 vs $75,000+	314.574	0.000	308.995	0.000	328.720	0.000
	$65,000-$74,999 vs Others	0.007	0.933	0.987	0.321	0.450	0.502
	$75,000+ vs Others	0.160	0.690	0.267	0.605	0.029	0.864
	Rural-Urban Continuum Code
	Counties in metropolitan areas greater than 1 million population vs Counties in metropolitan areas of 250,000 to 1 million population	154.789	0.000	89.246	0.000	118.829	0.000
	Counties in metropolitan areas greater than 1 million population vs Counties in metropolitan areas of less than 250 thousand population	489.541	0.000	339.405	0.000	414.594	0.000
	Counties in metropolitan areas greater than 1 million population vs Nonmetropolitan counties adjacent to a metropolitan area	898.955	0.000	628.695	0.000	771.331	0.000
	Counties in metropolitan areas greater than 1 million population vs Nonmetropolitan counties not adjacent to a metropolitan area	1,002.371	0.000	758.392	0.000	899.192	0.000
	Counties in metropolitan areas greater than 1 million population vs Others	22.407	0.000	9.820	0.002	15.310	0.000
	Counties in metropolitan areas of 250,000 to 1 million population vs Counties in metropolitan areas of less than 250 thousand population	132.516	0.000	103.077	0.000	119.878	0.000
	Counties in metropolitan areas of 250,000 to 1 million population vs Nonmetropolitan counties adjacent to a metropolitan area	343.469	0.000	256.190	0.000	307.174	0.000
	Counties in metropolitan areas of 250,000 to 1 million population vs Nonmetropolitan counties not adjacent to a metropolitan area	471.405	0.000	381.350	0.000	441.650	0.000
	Counties in metropolitan areas of 250,000 to 1 million population vs Others	12.395	0.000	4.685	0.030	7.959	0.005
	Counties in metropolitan areas of less than 250 thousand population vs Nonmetropolitan counties adjacent to a metropolitan area	36.154	0.000	24.804	0.000	31.550	0.000
	Counties in metropolitan areas of less than 250 thousand population vs Nonmetropolitan counties not adjacent to a metropolitan area	102.205	0.000	84.179	0.000	98.169	0.000
	Counties in metropolitan areas of less than 250 thousand population vs Others	3.187	0.074	0.355	0.551	1.314	0.252
	Nonmetropolitan counties adjacent to a metropolitan area vs Nonmetropolitan County not adjacent to a metropolitan area	21.335	0.000	21.435	0.000	22.933	0.000
	Nonmetropolitan counties adjacent to a metropolitan area vs Others	0.529	0.467	0.090	0.764	0.022	0.882
	Nonmetropolitan counties not adjacent to a metropolitan area vs Others	0.031	0.860	1.436	0.231	0.617	0.432
	Primary site
	Right upper lobe vs Right middle lobe	162.922	0.000	80.685	0.000	116.572	0.000
	Right upper lobe vs Right lower lobe	54.723	0.000	68.757	0.000	64.783	0.000
	Right upper lobe vs Left upper lobe	168.685	0.000	76.857	0.000	122.258	0.000
	Right upper lobe vs Left lower lobe	19.496	0.000	15.767	0.000	19.963	0.000
	Right upper lobe vs Main bronchus	10,216.526	0.000	10,257.262	0.000	10,769.433	0.000
	Right upper lobe vs Over lapping lesion of lung	595.338	0.000	829.226	0.000	770.682	0.000
	Right upper lobe vs Lung, NOS	37,093.583	0.000	36,323.045	0.000	38,235.231	0.000
	Right upper lobe vs Others	699.934	0.000	612.111	0.000	668.653	0.000
	Right middle lobe vs Right lower lobe	263.986	0.000	173.472	0.000	217.803	0.000
	Right middle lobe vs Left upper lobe	383.715	0.000	183.845	0.000	276.207	0.000
	Right middle lobe vs Left lower lobe	203.992	0.000	112.926	0.000	158.356	0.000
	Right middle lobe vs Main bronchus	6,517.198	0.000	5,704.728	0.000	6,423.992	0.000
	Right middle lobe vs Over lapping lesion of lung	779.740	0.000	877.108	0.000	882.311	0.000
	Right middle lobe vs Lung, NOS	13,575.417	0.000	11,318.686	0.000	13,058.521	0.000
	Right middle lobe vs Others	827.004	0.000	682.774	0.000	765.542	0.000
	Right lower lobe vs Left upper lobe	13.780	0.000	0.580	0.446	2.000	0.157
	Right lower lobe vs Left lower lobe	4.529	0.033	10.831	0.001	6.940	0.008
	Right lower lobe vs Main bronchus	7,741.953	0.000	7,473.661	0.000	8,027.688	0.000
	Right lower lobe vs Over lapping lesion of lung	446.655	0.000	621.232	0.000	581.078	0.000
	Right lower lobe vs Lung, NOS	23,928.595	0.000	22,385.509	0.000	24,235.716	0.000
	Right lower lobe vs Others	609.686	0.000	513.797	0.000	571.712	0.000
	Left upper lobe vs Left lower lobe	33.598	0.000	8.632	0.003	17.905	0.000
	Left upper lobe vs Main bronchus	8,554.529	0.000	8,966.598	0.000	9,271.170	0.000
	Left upper lobe vs Over lapping lesion of lung	419.865	0.000	684.012	0.000	599.494	0.000
	Left upper lobe vs Lung, NOS	30,093.214	0.000	30,515.243	0.000	31,760.602	0.000
	Left upper lobe vs Others	604.525	0.000	551.023	0.000	591.460	0.000
	Left lower lobe vs Main bronchus	7,605.617	0.000	7,473.549	0.000	7,956.885	0.000
	Left lower lobe vs Over lapping lesion of lung	487.337	0.000	692.059	0.000	636.294	0.000
	Left lower lobe vs Lung, NOS	21,655.850	0.000	20,479.488	0.000	22,098.264	0.000
	Left lower lobe vs Others	639.715	0.000	558.856	0.000	611.053	0.000
	Main bronchus vs Over lapping lesion of lung	574.941	0.000	374.213	0.000	491.592	0.000
	Main bronchus vs Lung, NOS	482.626	0.000	590.283	0.000	555.427	0.000
	Main bronchus vs Others	1.595	0.207	8.097	0.004	5.825	0.016
	Over lapping lesion of lung vs Lung, NOS	1,416.129	0.000	1,047.110	0.000	1,270.005	0.000
	Over lapping lesion of lung vs Others	122.072	0.000	55.546	0.000	83.040	0.000
	Lung, NOS vs Others	52.256	0.000	91.285	0.000	79.609	0.000
	Right upper lobe vs Other single lobes	71.499	0.000	53.158	0.000	66.958	0.000
	Right middle lobe vs Other single lobes	284.671	0.000	149.788	0.000	212.357	0.000
	Right lower lobe vs Other single lobes	21.601	0.000	43.991	0.000	32.919	0.000
	Left upper lobe vs Other single lobes	174.418	0.000	57.640	0.000	108.889	0.000
	Left lower lobe vs Other single lobes	0.963	0.326	1.070	0.301	1.432	0.231
	Main bronchus vs Single lobes	11,026.346	0.000	11,283.718	0.000	11,727.875	0.000
	Over lapping lesion of lung vs Single lobes	547.887	0.000	786.542	0.000	722.280	0.000
	Lung, NOS vs Single lobes	50,039.338	0.000	51,295.080	0.000	52,602.027	0.000
	Histologic type (ICD-O-3)
	Neoplasia, NAS vs Epithelial neoplasms, NAS	3,757.214	0.000	7,408.176	0.000	5,986.605	0.000
	Neoplasia, NAS vs Squamous cell neoplasms	20,217.196	0.000	27,516.738	0.000	25,146.774	0.000
	Neoplasia, NAS vs Adenoma and adenocarcinomas	35,445.959	0.000	40,577.637	0.000	39,259.802	0.000
	Neoplasia, NAS vs Cystic, mucinous and serous neoplasms	6,149.905	0.000	6,029.979	0.000	6,450.057	0.000
	Neoplasia, NAS vs Acinous cell neoplasm	11,950.640	0.000	10,107.204	0.000	11,760.036	0.000
	Neoplasia, NAS vs Complex epithelial neoplasms	4,939.508	0.000	5,491.534	0.000	5,632.441	0.000
	Neoplasia, NAS vs Others	1,961.725	0.000	1,547.515	0.000	1,799.985	0.000
	Epithelial neoplasms, NAS vs Squamous cell neoplasms	18,051.629	0.000	18,642.122	0.000	19,723.395	0.000
	Epithelial neoplasms, NAS vs Adenoma and adenocarcinomas	52,956.139	0.000	43,604.909	0.000	49,887.906	0.000
	Epithelial neoplasms, NAS vs Cystic, mucinous and serous neoplasms	3,920.902	0.000	2,832.710	0.000	3,530.938	0.000
	Epithelial neoplasms, NAS vs Acinous cell neoplasm	9,902.939	0.000	8,306.628	0.000	9,832.557	0.000
	Epithelial neoplasms, NAS vs Complex epithelial neoplasms	2,880.374	0.000	2,512.595	0.000	2,904.016	0.000
	Neoplasia, NAS vs Complex epithelial neoplasms	4,939.508	0.000	5,491.534	0.000	5,632.441	0.000
	Epithelial neoplasms, NAS vs Others	1,183.182	0.000	575.683	0.000	841.398	0.000
	Squamous cell neoplasms vs Adenoma and adenocarcinomas	4,324.050	0.000	2,002.280	0.000	2,974.305	0.000
	Squamous cell neoplasms vs Cystic, mucinous and serous neoplasms	526.311	0.000	232.401	0.000	355.225	0.000
	Squamous cell neoplasms vs Acinous cell neoplasm	5,171.203	0.000	4,982.770	0.000	5,383.737	0.000
	Squamous cell neoplasms vs Complex epithelial neoplasms	246.850	0.000	171.523	0.000	210.048	0.000
	Squamous cell neoplasms vs Others	211.562	0.000	15.811	0.000	64.762	0.000
	Adenoma and adenocarcinomas vs Cystic, mucinous and serous neoplasms	9.479	0.002	4.511	0.034	6.611	0.010
	Adenoma and adenocarcinomas vs Acinous cell neoplasm	3,429.157	0.000	3,748.082	0.000	3,805.019	0.000
	Adenoma and adenocarcinomas vs Complex epithelial neoplasms	14.960	0.000	0.000	0.991	2.697	0.101
	Adenoma and adenocarcinomas vs Others	10.571	0.001	7.914	0.005	0.424	0.515
	Cystic, mucinous and serous neoplasms vs Acinous cell neoplasm	2,508.321	0.000	3,023.062	0.000	2,957.332	0.000
	Cystic, mucinous and serous neoplasms vs Complex epithelial neoplasms	24.420	0.000	2.074	0.150	8.732	0.003
	Cystic, mucinous and serous neoplasms vs Others	0.961	0.327	12.862	0.000	3.988	0.046
	Acinous cell neoplasm vs Complex epithelial neoplasms	2,915.827	0.000	3,292.872	0.000	3,306.154	0.000
	Acinous cell neoplasm vs Others	1,432.131	0.000	2,382.199	0.000	2,110.827	0.000
	Complex epithelial neoplasms vs Others	20.792	0.000	6.543	0.011	0.027	0.871
	Summary stage
	Distant vs Localized	189,234.197	0.000	157,689.763	0.000	180,494.909	0.000
	Distant vs Regional	95,182.979	0.000	89,552.783	0.000	97,474.996	0.000
	Distant vs Unknown/unstaged	2,281.394	0.000	1,319.592	0.000	1,873.692	0.000
	Localized vs Regional	22,646.800	0.000	24,779.500	0.000	25,260.467	0.000
	Localized vs Unknown/unstaged	54,328.909	0.000	60,221.013	0.000	59,752.077	0.000
	Regional vs Unknown/unstaged	15,840.215	0.000	19,402.780	0.000	18,494.477	0.000

Table 3 Univariate and Multivariate Cox Proportional Hazards Analysis of Lung Cancer Based on SEER Database

Types of Cox Analysis	Comparing Factors	B	SE	Wald	df	Sig.	HR	95.0% HR, CI
								Lower	Upper
Univariate	Primary site			51,359.75	8	0.000
	Right middle lobe vs Right upper lobe	−0.075	0.006	152.810	1	0.000	0.927	0.916	0.939
	Right lower lobe vs Right upper lobe	0.027	0.004	49.306	1	0.000	1.027	1.019	1.035
	Left upper lobe vs Right upper lobe	0.041	0.003	151.521	1	0.000	1.042	1.035	1.048
	Left lower lobe vs Right upper lobe	0.017	0.004	16.670	1	0.000	1.017	1.009	1.025
	Main bronchus vs Right upper lobe	0.528	0.005	9,373.596	1	0.000	1.696	1.678	1.714
	Over lapping lesion of lung vs Right upper lobe	0.247	0.010	557.362	1	0.000	1.280	1.254	1.306
	Lung, NOS vs Right upper lobe	0.654	0.004	34,847.930	1	0.000	1.923	1.910	1.937
	Others (a) vs Right upper lobe	0.511	0.020	626.507	1	0.000	1.666	1.601	1.734
	Sex
	Male vs Female	0.215	0.002	8,886.971	1	0.000	1.240	1.234	1.245
	Age			33,386.410	5	0.000
	45–54 years vs < 45 years	0.277	0.010	724.156	1	0.000	1.319	1.293	1.346
	55–64 years vs < 45 years	0.343	0.010	1,225.613	1	0.000	1.409	1.382	1.436
	65–74 years vs < 45 years	0.426	0.010	1,941.140	1	0.000	1.532	1.503	1.561
	75–84 years vs < 45 years	0.658	0.010	4,590.031	1	0.000	1.931	1.894	1.968
	85+ years vs < 45 years	1.001	0.010	9,588.206	1	0.000	2.722	2.668	2.777
	Race			1,222.947	2	0.000
	Black vs White	0.059	0.004	263.022	1	0.000	1.061	1.053	1.068
	Others (b) vs White	−0.144	0.005	867.837	1	0.000	0.865	0.857	0.874
	Origin recode NHIA
	Non-Spanish-Hispanic-Latino vs Spanish-Hispanic-Latino	0.016	0.005	9.888	1	0.002	1.016	1.006	1.027
	Median household income inflation adj to 2019			2,931.738	6	0.000
	$35,000–$44,999 vs <$35,000	−0.054	0.009	38.994	1	0.000	0.948	0.932	0.964
	$45,000–$54,999 vs <$35,000	−0.072	0.008	78.900	1	0.000	0.930	0.915	0.945
	$55,000–$64,999 vs <$35,000	−0.119	0.008	220.252	1	0.000	0.888	0.874	0.902
	$65,000–$74,999 vs <$35,000	−0.163	0.008	407.928	1	0.000	0.850	0.836	0.863
	$75,000+ vs <$35,000	−0.219	0.008	756.831	1	0.000	0.803	0.790	0.816
	Others (c) vs <$35,000	−0.173	0.123	1.967	1	0.161	0.841	0.661	1.071
	Rural-Urban Continuum			1,835.107	5	0.000
	Counties in metropolitan areas of 250,000 to 1 million pop vs Counties in metropolitan areas of greater than 1 million pop	0.036	0.003	146.527	1	0.000	1.037	1.031	1.043
	Counties in metropolitan areas of less than 250 thousand pop vs Counties in metropolitan areas of greater than 1 million pop	0.087	0.004	462.909	1	0.000	1.091	1.083	1.100
	Nonmetropolitan counties adjacent to a metropolitan area vs Counties in metropolitan areas of greater than 1 million pop	0.118	0.004	848.592	1	0.000	1.126	1.117	1.135
	Nonmetropolitan counties not adjacent to a metropolitan vs Counties in metropolitan areas of greater than 1 million pop	0.144	0.005	946.941	1	0.000	1.155	1.144	1.166
	Others (d) vs Counties in metropolitan areas of greater than 1 million pop	0.139	0.030	21.202	1	0.000	1.149	1.083	1.220
	Histologic type (ICD-O-3)			74,262.360	7	0.000
	Epithelial neoplasms, NAS vs Neoplasia, NAS	−0.296	0.005	3,638.861	1	0.000	0.744	0.737	0.751
	Squamous cell neoplasms vs Neoplasia, NAS	−0.700	0.005	18,147.780	1	0.000	0.497	0.492	0.502
	Adenoma and adenocarcinomas vs Neoplasia, NAS	−0.900	0.005	33,303.950	1	0.000	0.406	0.403	0.410
	Cystic, mucinous and serous neoplasms vs Neoplasia, NAS	−0.933	0.011	6,687.317	1	0.000	0.393	0.385	0.402
	Acinous cell neoplasm vs Neoplasia, NAS	−2.005	0.021	9,539.132	1	0.000	0.135	0.129	0.140
	Complex epithelial neoplasms vs Neoplasia, NAS	−0.859	0.012	5,433.430	1	0.000	0.424	0.414	0.433
	Others (e) vs Neoplasia, NAS	−0.962	0.020	2,265.927	1	0.000	0.382	0.367	0.398
	Year of diagnosis			7,025.014	17	0.000
	2001 vs 2000	−0.006	0.007	0.709	1	0.400	0.994	0.982	1.007
	2002 vs 2000	−0.006	0.007	0.912	1	0.339	0.994	0.981	1.007
	2003 vs 2000	−0.022	0.007	11.283	1	0.001	0.978	0.966	0.991
	2004 vs 2000	−0.038	0.007	33.250	1	0.000	0.963	0.951	0.975
	2005 vs 2000	−0.054	0.007	68.099	1	0.000	0.947	0.935	0.960
	2006 vs 2000	−0.077	0.007	136.769	1	0.000	0.926	0.914	0.938
	2007 vs 2000	−0.088	0.007	181.709	1	0.000	0.915	0.904	0.927
	2008 vs 2000	−0.104	0.007	252.221	1	0.000	0.901	0.889	0.913
	2009 vs 2000	−0.117	0.007	315.202	1	0.000	0.890	0.878	0.901
	2010 vs 2000	−0.131	0.007	388.059	1	0.000	0.877	0.866	0.889
	2011 vs 2000	−0.162	0.007	586.987	1	0.000	0.850	0.839	0.861
	2012 vs 2000	−0.156	0.007	540.690	1	0.000	0.855	0.844	0.867
	2013 vs 2000	−0.182	0.007	724.595	1	0.000	0.833	0.822	0.844
	2014 vs 2000	−0.220	0.007	1,029.316	1	0.000	0.803	0.792	0.814
	2015 vs 2000	−0.271	0.007	1,512.721	1	0.000	0.762	0.752	0.773
	2016 vs 2000	−0.311	0.007	1,876.193	1	0.000	0.733	0.722	0.743
	2017 vs 2000	−0.348	0.008	2,105.528	1	0.000	0.706	0.696	0.717
	Summary stage			205,903.400	3	0
	Localized vs Distant	−1.426	0.004	165,939.800	1	0	0.240	0.239	0.242
	Regional vs Distant	−0.884	0.003	90,444.560	1	0	0.413	0.411	0.415
	Unknown/unstaged vs Distant	−0.256	0.005	2,733.579	1	0	0.774	0.767	0.782
Multivariate	Primary Site			30,355.820	8	0.000
	Right middle lobe vs Right upper lobe	−0.045	0.006	55.071	1	0.000	0.956	0.944	0.967
	Right lower lobe vs Right upper lobe	0.038	0.004	100.117	1	0.000	1.039	1.031	1.047
	Left upper lobe vs Right upper lobe	0.028	0.003	71.195	1	0.000	1.028	1.022	1.035
	Left lower lobe vs Right upper lobe	0.031	0.004	55.730	1	0.000	1.031	1.023	1.040
	Main bronchus vs Right upper lobe	0.446	0.005	6,583.468	1	0.000	1.562	1.545	1.579
	Over lapping lesion of lung vs Right upper lobe	0.257	0.010	603.009	1	0.000	1.293	1.267	1.320
	Lung, NOS vs Right upper lobe	0.519	0.004	20,830.791	1	0.000	1.681	1.669	1.693
	Others (f) vs Right upper lobe	0.424	0.020	431.055	1	0.000	1.528	1.468	1.590
	Sex
	Male vs Female	0.197	0.002	7,283.054	1	0.000	1.217	1.212	1.223
	Age			29,870.587	5	0.000
	45–54 years vs < 45 years	0.261	0.010	639.066	1	0.000	1.299	1.272	1.325
	55–64 years vs < 45 years	0.348	0.010	1,254.460	1	0.000	1.417	1.389	1.444
	65–74 years vs < 45 years	0.459	0.010	2,223.302	1	0.000	1.582	1.552	1.613
	75–84 years vs < 45 years	0.688	0.010	4,960.363	1	0.000	1.990	1.952	2.029
	85+ years vs < 45 years	0.960	0.010	8,635.988	1	0.000	2.611	2.559	2.665
	Race			849.583	2	0.000
	Black vs White	0.095	0.004	642.820	1	0.000	1.099	1.091	1.108
	Others (g) vs White	−0.062	0.005	153.648	1	0.000	0.939	0.930	0.949
	Origin recode NHIA
	Non-Spanish-Hispanic-Latino vs Spanish-Hispanic-Latino	0.018	0.005	12.181	1	0.000	1.018	1.008	1.029
	Median household income inflation adj to 2019			1,279.382	6	0.000
	$35,000–$44,999 vs <$35,000	−0.055	0.009	37.947	1	0.000	0.946	0.930	0.963
	$45,000–$54,999 vs <$35,000	−0.082	0.009	87.256	1	0.000	0.921	0.905	0.937
	$55,000–$64,999 vs <$35,000	−0.126	0.009	194.220	1	0.000	0.881	0.866	0.897
	$65,000–$74,999 vs <$35,000	−0.165	0.009	316.049	1	0.000	0.848	0.833	0.864
	$75,000+ vs <$35,000	−0.203	0.009	479.380	1	0.000	0.816	0.802	0.831
	Others (h) vs <$35,000	−0.773	0.127	36.796	1	0.000	0.462	0.360	0.593
	Rural-Urban Continuum			83.075	5	0.000
	Counties in metropolitan areas of 250,000 to 1 million pop vs Counties in metropolitan areas of greater than 1 million pop	0.013	0.003	19.031	1	0.000	1.014	1.007	1.020
	Counties in metropolitan areas of less than 250 thousand pop vs Counties in metropolitan areas of greater than 1 million pop	0.001	0.004	0.068	1	0.795	1.001	0.992	1.010
	Nonmetropolitan counties adjacent to a metropolitan area vs Counties in metropolitan areas of greater than 1 million pop	−0.005	0.005	0.897	1	0.344	0.995	0.986	1.005
	Nonmetropolitan counties not adjacent to a metropolitan vs Counties in metropolitan areas of greater than 1 million pop	0.008	0.006	1.923	1	0.166	1.008	0.997	1.020
	Others (i) vs Counties in metropolitan areas of greater than 1 million pop	0.243	0.032	59.247	1	0.000	1.275	1.199	1.357
	Histologic type ICDO3			42,139.807	7	0.000
	Epithelial neoplasms, NAS vs Neoplasia, NAS	−0.053	0.005	106.351	1	0.000	0.949	0.939	0.958
	Squamous cell neoplasms vs Neoplasia, NAS	−0.428	0.005	6,132.065	1	0.000	0.652	0.645	0.659
	Adenoma and adenocarcinomas vs Neoplasia, NAS	−0.557	0.005	11,534.349	1	0.000	0.573	0.567	0.579
	Cystic, mucinous and serous neoplasms vs Neoplasia, NAS	−0.578	0.012	2,506.946	1	0.000	0.561	0.549	0.574
	Acinous cell neoplasm vs Neoplasia, NAS	−1.553	0.021	5,656.729	1	0.000	0.212	0.203	0.220
	Complex epithelial neoplasms vs Neoplasia, NAS	−0.533	0.012	2,045.116	1	0.000	0.587	0.574	0.601
	Others (j) vs Neoplasia, NAS	−0.619	0.020	928.675	1	0.000	0.539	0.518	0.560
	Year of diagnosis			2,414.036	17	0.000
	2001 vs 2000	−0.010	0.007	2.319	1	0.128	0.990	0.977	1.003
	2002 vs 2000	−0.014	0.007	4.348	1	0.037	0.986	0.974	0.999
	2003 vs 2000	−0.034	0.007	27.497	1	0.000	0.966	0.954	0.979
	2004 vs 2000	−0.050	0.007	58.507	1	0.000	0.951	0.939	0.963
	2005 vs 2000	−0.061	0.007	86.634	1	0.000	0.941	0.929	0.953
	2006 vs 2000	−0.079	0.007	142.858	1	0.000	0.924	0.913	0.936
	2007 vs 2000	−0.083	0.007	159.809	1	0.000	0.920	0.908	0.932
	2008 vs 2000	−0.092	0.007	193.962	1	0.000	0.912	0.900	0.924
	2009 vs 2000	−0.099	0.007	223.976	1	0.000	0.906	0.894	0.918
	2010 vs 2000	−0.100	0.007	224.238	1	0.000	0.905	0.893	0.917
	2011 vs 2000	−0.110	0.007	267.803	1	0.000	0.896	0.884	0.907
	2012 vs 2000	−0.100	0.007	218.197	1	0.000	0.905	0.893	0.917
	2013 vs 2000	−0.115	0.007	283.473	1	0.000	0.891	0.880	0.903
	2014 vs 2000	−0.141	0.007	418.512	1	0.000	0.868	0.857	0.880
	2015 vs 2000	−0.176	0.007	631.345	1	0.000	0.838	0.827	0.850
	2016 vs 2000	−0.200	0.007	762.693	1	0.000	0.819	0.808	0.831
	2017 vs 2000	−0.231	0.008	918.224	1	0.000	0.794	0.782	0.806
	Summary stage			184,737.000	3	0.000
	Localized vs Distant	−1.385	0.004	149,948.100	1	0.000	0.250	0.248	0.252
	Regional vs Distant	−0.854	0.003	82,171.650	1	0.000	0.426	0.423	0.428
	Unknown/unstaged vs Distant	−0.533	0.005	11,191.940	1	0.000	0.587	0.581	0.593

Notes: (a) Others included Only one side - side unspecified, Bilateral, single primary and Paired site, but no information concerning laterality. (b) Others included Asian or Pacific Islander and American Indian/Alaska Native. (c) Others included unknown/missing/no match/Not 1990–2018. (d) Others included Unknown/missing/no match (Alaska or Hawaii - Entire State) and Unknown/missing/no match/Not 1990–2018. (e) Others included all the histological types of lung cancer except the above seven types. (f) Others included Only one side - side unspecified, Bilateral, single primary and Paired site, but no information concerning laterality. (g) Others included Asian or Pacific Islander and American Indian/Alaska Native (h) Others included unknown/missing/no match/Not 1990–2018 (i) Others included Unknown/missing/no match (Alaska or Hawaii - Entire State) and Unknown/missing/no match/Not 1990–2018. (j) Others included all the histological types of lung cancer except the above seven types.

Figure 1 Median survival time. Survival and its growth rate in lung cancer patients from 2000 to 2017. (A and B) According to sex. (C and D) According to primary site. (E and F) According to age. (G and H) According to median household income (inflation adjusted to 2019). (I and J) According to address. (K and L) According to histologic type. (M and N) According to race. (O and P) According to ethnic group.

Figure 2 Kaplan–Meier survival curves of lung cancer patients according to primary site and demographics. (A) All primary site groups. (B) Right upper lobe. (C) Right middle lobe. (D) Right lower lobe. (E) Left upper lobe. (F) Left lower lobe. (G) Main bronchus. (H) Overlapping lesion of lung. (I) Right upper lobe and right middle lobe. (J) Right upper lobe and right lower lobe. (K) Right upper lobe and left upper lobe. (L) Right upper lobe and left lower lobe. (M) Middle lobe and right lower lobe. (N) Right middle lobe and left upper lobe. (O) Middle lobe and left lower lobe. (P) Right lower lobe and left upper lobe. (Q) Right lower lobe and left lower lobe. (R) Left upper lobe and left lower lobe. (S) Address groups. (T) Income groups. (U) Ethnic groups. (V) Age groups. (W) Race groups. (X) Sex groups.

Figure 3 Survival curves of different summary stages and changes in median survival time of lung cancer patients from 2000 to 2017. (A) Median survival time of lung cancer patients at different summary stages from 2000 to 2017. (B) Increase in median survival time of lung cancer patients at different summary stages from 2000 to 2017. (C) Kaplan–Meier survival curves for different summary stages.