Long Non-Coding RNA HOTAIR Expression and Clinical Significance in Patients with Gestational Diabetes

Figures & data

Table 1 Clinical Data of the Subject Population

Characteristics	Healthy Pregnant Women (n=98)	Gestational Diabetes Mellitus (n=99)	P-value
Age (years)	29.12±1.10	29.39±1.05	0.77
BMI (kg/m^2)	25.00±3.07	27.82±4.51	<0.001
Gestation (week)	26.79±1.18	26.72±1.65	0.747
Fasting plasma glucose (mM)	4.52±0.32	5.30±0.11	<0.001
One-hour plasma glucose (mM)	6.27±0.21	10.21±0.27	<0.001
Two-hour plasma glucose (mM)	5.47±0.42	8.28±0.19	<0.001
Fetal birth weight (g)	3409.35±263.52	3430.46±202.66	0.529
Total cholesterol (mM)	5.49±0.41	5.91±0.46	<0.001
Triacylglycerol (mM)	0.99±0.33	1.28±0.34	<0.001
Low-density lipoprotein cholesterol (mM)	2.62±0.43	2.73±0.41	0.109

Note: Data are expressed as n or mean ± standard deviation.

Abbreviation: BMI, body mass index.

Figure 1 HOX transcript antisenseRNA (HOTAIR) expression was enhanced in pregnant women with gestational diabetes mellitus (GDM) (***P < 0.001).

Figure 2 Receiver operating characteristic (ROC) curve was drawn to estimate the diagnostic significance of HOX transcript antisenseRNA (HOTAIR) in gestational diabetes mellitus (GDM).

Table 2 Correlation Between lncRNA HOTAIR and Clinical Characteristics

Characteristics	Correlation with lncRNA HOTAIR	P-value
Age (years)	0.152	0.132
BMI (kg/m^2)	0.297	0.003
Gestation (week)	0.068	0.506
Fasting plasma glucose (mM)	0.614	<0.001
One-hour plasma glucose (mM)	0.588	<0.001
Two-hour plasma glucose (mM)	0.417	<0.001
Fetal birth weight (g)	0.023	0.819
Total cholesterol (mM)	0.070	0.187
Triacylglycerol (mM)	0.134	0.491
Low-density lipoprotein cholesterol (mM)	0.095	0.352

Abbreviation: BMI, body mass index.

Table 3 Association of Different Variables with the Occurrence of Gestational Diabetes Mellitus

Characteristics	OR	95% CI	P value
LncRNA HOTAIR	20.939	9.415–46.567	<0.001
Age (years)	1.422	0.611–3.310	0.414
BMI (kg/m^2)	2.999	1.348–6.670	0.007
Gestation (week)	1.954	0.853–4.476	0.113
Fetal birth weight (g)	1.380	0.629–3.028	0.421
Total cholesterol (mM)	1.777	0.770–4.103	0.178
Triacylglycerol (mM)	2.009	0.897–4.497	0.090
Low-density lipoprotein cholesterol (mM)	1.073	0.474–2.429	0.886

Abbreviation: BMI, body mass index.