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Original Research

CCNB2, CDC20, AURKA, TOP2A, MELK, NCAPG, KIF20A, UBE2C, PRC1, and ASPM May Be Potential Therapeutic Targets for Hepatocellular Carcinoma Using Integrated Bioinformatic Analysis

ORCID Icon, , , , &
Pages 10185-10194 | Published online: 22 Dec 2021

Figures & data

Table 1 Top Ten Hub Genes with Higher Degree of Connectivity

Figure 1 Flow diagram of bioinformatics analysis.

Figure 1 Flow diagram of bioinformatics analysis.

Table 2 Statistics of the Three Microarray Databases Derived from the GEO Database

Figure 2 Venn diagram of DEGs common to all three GEO datasets.

Notes: (A) Upregulated genes. (B) Downregulated genes.
Abbreviations: DEG, differentially expressed gene; GEO, Gene Expression Omnibus.
Figure 2 Venn diagram of DEGs common to all three GEO datasets.

Table 3 Significantly Enriched GO Terms and KEGG Pathways of DEGs

Figure 3 Protein–protein interaction network of the differentially expressed genes in hepatocellular carcinoma.

Note: Red nodes represent upregulated genes, and green nodes represent downregulated genes.
Figure 3 Protein–protein interaction network of the differentially expressed genes in hepatocellular carcinoma.

Figure 4 Hub genes screened from protein–protein interaction network.

Figure 4 Hub genes screened from protein–protein interaction network.

Figure 5 Kaplan–Meier overall survival analyses for the top ten hub genes expressed in hepatocellular carcinoma patients.

Figure 5 Kaplan–Meier overall survival analyses for the top ten hub genes expressed in hepatocellular carcinoma patients.

Figure 6 Kaplan–Meier relapse-free survival analyses for for the top ten hub genes expressed in hepatocellular carcinoma patients.

Figure 6 Kaplan–Meier relapse-free survival analyses for for the top ten hub genes expressed in hepatocellular carcinoma patients.

Figure 7 Representative protein expression of the nine hub genes.

Figure 7 Representative protein expression of the nine hub genes.