Aspirin-Induced Delayed Urticaria in Children with Kawasaki Disease: A Retrospective Case-Control Study

Figures & data

Table 1 Demographics, Weight and Allergy History

	Case Group (n=46)	Control Group (n=89)	p-value
Sex (male/female)	22/24	56/33	0.09
Age (y)	1.8 (0.8, 2.5)	1.9 (1.1, 3.0)	0.45
Weight (kg)	11.5 (10.0, 14.0)	12 (10.5, 15.0)	0.21
Drug allergy history, n (%)	4 (8.7%)	10 (11.2%)	0.87
Food or other allergy history, n (%)	2 (4.3%)	8 (9.0%)	0.53

Table 2 Blood Testing Results at Admission

	Case	Control	p-value
White blood cells (×10^9/L)	17.0±6.3	15.0±5.3	0.05
Neutrophil percent (%)	75.2 (62.7, 81.2)	65.2 (54.3, 75.9)	0.01
Monocyte percent (%)	5.0 (4.0, 7.0)	5.6 (4.2, 7.5)	0.43
Eosinophils percent (%)	1.9 (0.9, 4.2)	2.6 (1.2, 4.9)	0.16
Hemoglobin (g/L)	109.5±12.1	105.2±12.6	0.06
Platelets (×10^9/L)	387 (305, 523)	376 (309, 566)	0.98
C-reactive protein (mg/L)	80.4 (62.5, 121.5)	54.4 (30.5, 98.5)	0.03
ESR (mm/h)	65.1±29.1	67.9±26.3	0.61
TNF-α (pg/mL)	20.7 (14.4, 28.0)	22.2 (16.5, 40.3)	0.16
NT-BNP (pg/mL)	1233 (449, 2344)	481 (212, 897)	< 0.0001
ALT (U/L)	28.9 (14.7, 108.1)	28.9 (17.9, 76.4)	0.69
AST (U/L)	29.1 (21.0, 47.0)	30.6 (22.4, 62.4)	0.46
Albumin (g/L)	32.6±4.9	33.1±4.9	0.55
IgE (IU/mL)	60.3 (24.1, 178.8)	74.6 (18.1, 148.5)	0.80

Abbreviations: ESR, erythrocyte sedimentation rate; TNF, tumor necrosis factor; NT-BNP, N-terminal pro b-type natriuretic peptide; ALT, alanine aminotransferase; AST, aspartate aminotransferase.

Figure 1 Assessment of inflammatory parameters as predictors for AIU. The ROC curve analysis revealed that among the 3 significantly increased inflammatory parameters in children with AIU, baseline NT-proBNP had the highest AUC value in predicting AIU.

Table 3 Clinical Features and the Length of Hospital Stay

	Case	Control	p-value
KD-associated skin rashes, n (%)	40 (87.0%)	73 (82.0%)	0.52
KD-associated skin rash duration (d)	5.0 (4.0, 6.0)	4.0 (3.0, 6.0)	0.42
Fever duration (d)	7.0 (6.0, 8.0)	7.0 (6.0, 8.0)	0.99
IVIG-resistant cases, n (%)	3 (6.5%)	5 (5.6%)	1.00
Coronary artery lesions, n (%)	17 (37.0%)	39 (43.8%)	0.44
Length of hospital stay (d)	10.0 (8.0, 12.0)	8.0 (6.0, 9.0)	< 0.001

Abbreviations: KD, Kawasaki disease; IVIG, intravenous immunoglobulin.