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Original Research

Clinical-Epidemiological Characteristics and Mortality in Patients with Sickle Cell Anemia: A Retrospective Cohort Study of 1980 at 2018

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Pages 1057-1074 | Published online: 02 Feb 2022

Figures & data

Figure 1 Distribution of sickle-cell anemia cases in the municipalities of Mato Grosso do Sul, Brazil, between 1980 and 2018, per 100,000 inhabitants (n=125).

Notes: Three cases monitored by the services under study and residents in Itiquira (Mato Grosso, Brazil), a neighboring state to Mato Grosso do Sul, were not computed.
Figure 1 Distribution of sickle-cell anemia cases in the municipalities of Mato Grosso do Sul, Brazil, between 1980 and 2018, per 100,000 inhabitants (n=125).

Figure 2 Frequency and incidence (100,000 inhabitants) of the sickle-cell anemia cases stratified in decade of birth, monitored in Mato Grosso do Sul, Brazil (n=128).

Figure 2 Frequency and incidence (100,000 inhabitants) of the sickle-cell anemia cases stratified in decade of birth, monitored in Mato Grosso do Sul, Brazil (n=128).

Figure 3 Data on the total and number of days of hospitalization of the cohort in clinical ward and intensive care center, Campo Grande, Mato Grosso do Sul, Brazil (n=128).

Notes: (A) The median of hospitalization days per year; (B) Days during the entire follow-up; (C) Maximum interval between hospitalizations (∆T); (D) Number of intensive care center hospitalizations; (E) Days of stay in the intensive care center.
Figure 3 Data on the total and number of days of hospitalization of the cohort in clinical ward and intensive care center, Campo Grande, Mato Grosso do Sul, Brazil (n=128).

Figure 4 Percentage of cases with laboratory levels outside of the normal range, Campo Grande, Mato Grosso do Sul, Brazil (n=128).

Abbreviations: PCR, C-reactive protein; BI, Indirect bilirubin; BD, Direct bilirubin; LDH, lactic dehydrogenase; VCM, mean corpuscular volume; Hb, hemoglobin.
Figure 4 Percentage of cases with laboratory levels outside of the normal range, Campo Grande, Mato Grosso do Sul, Brazil (n=128).

Figure 5 Distribution of laboratory marker values from the cohort, Campo Grande, Mato Grosso do Sul, Brazil (n=128).

Notes: (A) levels of the hemoglobin; (B) levels of the leukocytes; (C) levels of the reticulocytes; (D) levels of the lactic dehydrogenase; (E) levels of the ferritin; (E) levels of the C-reactive protein; (F) levels of the creatinine; (G) levels of the direct bilirubin; (H) levels of the indirect bilirubin.
Figure 5 Distribution of laboratory marker values from the cohort, Campo Grande, Mato Grosso do Sul, Brazil (n=128).

Table 1 Main Clinical Complications of Patients with Sickle-Cell Anemia, Before and After the Use of Hydroxyurea, Monitored Between 1980 and 2018. Mato Grosso do Sul, Brazil, 2020 (n=128)

Figure 6 Data from the patients with sickle-cell anemia stratified by moments before and after the use of hydroxyurea.

Notes: (A) – First and last dose of prescribed hydroxyurea; (B) – Number of complications before and after initiation of hydroxyurea use; (C) – Number of hospitalization days before and after initiation of hydroxyurea use; (D) – The time interval between hospitalizations (∆T) before and after initiation of hydroxyurea use; (E) – Number of antimicrobials used before and after initiation of hydroxyurea use; (F) – Total hospitalizations before and after initiation of hydroxyurea use; (G) – Number of pain crises before and after initiation of hydroxyurea use; (H) – Use frequency of analgesic medication before and after initiation hydroxyurea use.
Figure 6 Data from the patients with sickle-cell anemia stratified by moments before and after the use of hydroxyurea.

Table 2 Use of Antimicrobials in the Periods Before and After the Use of Hydroxyurea in Patients with Sickle-Cell Anemia, Monitored Between 1980 and 2018. Mato Grosso do Sul, Brazil, 2020 (n=128)

Table 3 Causes of Death Stratification by Age at the Time of Death. Mato Grosso do Sul, Brazil, 2020 (n=19)

Table 4 Number of Deaths According to the Demographic and Clinical Data of Patients with Sickle-Cell Anemia, Monitored Between 1980 and 2018. Mato Grosso do Sul, Brazil, 2020 (n=128)

Table 5 Number of Deaths According to Medication Use and Procedures Performed in Patients with Sickle-Cell Anemia, Mato Grosso do Sul, Brazil, 2020 (n=128)

Figure 7 Distribution of values for laboratory markers between cases that died and those that survived, Campo Grande, Mato Grosso do Sul, Brazil (n=128).

Notes: (A) levels of de hemoglobin in cases of death and of survival; (B) levels of de mean corpuscular volume in cases of death and of survival; (C) levels of de leukocytes in cases of death and of survival; (D) levels of de reticulocytes in cases of death and of survival; (E) levels of de lactic dehydrogenase in cases of death and of survival; (F) levels of de C-reactive protein in cases of death and of survival; (G) levels of de direct bilirubin in cases of death and of survival; (H) levels of de indirect bilirubin in cases of death and of survival; (I) levels of de ferritin in cases of death and of survival; (J) levels of de creatinine in cases of death and of survival.
Figure 7 Distribution of values for laboratory markers between cases that died and those that survived, Campo Grande, Mato Grosso do Sul, Brazil (n=128).