Relationship of the Triglyceride-Glucose Index with Subclinical White Matter Hypersensitivities of Presumed Vascular Origin Among Community-Dwelling Koreans

Figures & data

Table 1 Clinical Characteristics of the Study Population According to TyG Index Quartiles

	TyG Index Quartiles
	Q1 (≤8.12)	Q2 (8.13–8.50)	Q3 (8.51–8.89)	Q4 (≥8.90)	P-value *	Post Hoc **
n	605	606	606	600
Age (years)	55.6 (8.2)	56.4 (8.4)	57.2 (8.2)	56.4 (7.9)	0.015	b
Females (%)	59.3	45.5	33.6	23.7	<0.001	-
Body mass index (kg/m^2)	22.5 (2.7)	23.7 (2.8)	24.4 (2.7)	25.2 (2.7)	<0.001	a,b,c,d,e,f
Systolic BP (mmHg)	121.6 (16.5)	123.7 (17.5)	128.8 (18.`)	129.0 (15.9)	<0.001	a,b,c,d,e,f
Diastolic BP (mmHg)	75.1 (9.9)	78.2 (9.9)	80.5 (10.0)	81.5 (9.7)	<0.001	a,b,c,d,e
Mean arterial BP (mmHg)	89.9 (11.4)	93.2 (11.8)	95.4 (11.7)	96.3 (12.4)	<0.001	a,b,c,d,e
Fasting plasma glucose (mg/dL)	88.6 (11.2)	96.0 (12.2)	101.2 (17.7)	114.2 (32.0)	<0.001	a,b,c,d,e,f
Total cholesterol (mg/dL)	185.9 (35.4)	193.1 (35.7)	194.0 (36.7)	199.4 (37.7)	<0.001	a,b,c,e,f
Triglyceride (mg/dL)	59 (58–60)	87 (86–88)	120 (119–122)	209 (203–215)	<0.001	a,b,c,d,e,f
HDL-cholesterol (mg/dL)	59.7 (13.7)	52.7 (12.3)	47.6 (10.3)	43.9 (10.3)	<0.001	a,b,c,d,e,f
LDL-cholesterol (mg/dL)	115.3 (32.0)	125.5 (32.0)	126.4 (33.4)	128.5 (34.0)	<0.001	a,b,c
Pulse wave velocity (cm/s)	1371 (230)	1428 (255)	1456 (256)	1480 (257)	<0.001	a,b,c,e,
Leukocyte count (cells/μL)	4637 (2130)	5144 (2303)	5499 (2387)	5797 (2682)	<0.001	a,b,c,d,e,f
Current smokers (%)	23.3	33.1	35.3	36.5	<0.001	–
Alcohol drinking (%)	24.8	28.4	32.1	40.6	<0.001	–
Regular exercise (%)	44.7	43.5	44.7	38.9	0.153	–
Hypertension (%)	26.1	38.2	47.6	49.7	<0.001	–
Type 2 diabetes (%)	3.8	7.1	11.2	25.3	<0.001	–
Metabolic syndrome (%)	3.0	7.1	15.7	53.4	<0.001	–
White matter hypersensitivities (%)	7.6	8.9	8.6	12.1	0.029	–

Notes: Data are expressed as the mean (SD) or percentage. * P-values were calculated using one-way ANOVA, Kruskal–Wallis or Pearson’s chi-square tests. ** Post hoc analysis with the Bonferroni method: a, Q1 versus Q2; b, Q1 versus Q3; c, Q1 versus Q4; d, Q2 versus Q3; e, Q2 versus Q4, and f, Q3 versus Q4.

Abbreviations: BP, blood pressure; HDL, high-density lipoprotein; LDL, low-density lipoprotein.

Table 2 Odds Ratios and 95% Confidence for White Matter Hypersensitivities According to TyG Index Quartiles

	TyG Index Quartiles
	Q1 (≤8.12)	Q2 (8.13–8.50)	Q3 (8.51–8.89)	Q4 (≥8.90)	P for Trend
Model 1	1.00	1.47 (0.91–2.39)	1.74 (1.04–2.93)	6.38 (3.71–11.13)	< 0.001
Model 2	1.00	1.44 (0.89–2.35)	1.70 (1.02–2.86)	6.20 (3.61–10.84)	< 0.001
Model 3	1.00	1.47 (0.91–2.40)	1.76 (1.05–2.97)	6.79 (3.85–11.54)	< 0.001

Notes: Model 1: adjusted for age, sex, body mass index, smoking status, alcohol intake, regular exercise, mean arterial pressure, C-reactive protein, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol. Model 2: adjusted for age, sex, body mass index, smoking status, alcohol intake, regular exercise, mean arterial pressure, C-reactive protein, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and hypertension. Model 3: adjusted for age, sex, body mass index, smoking status, alcohol intake, regular exercise, mean arterial pressure, C-reactive protein, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, hypertension, and type 2 diabetes.