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International Journal of General Medicine Volume 15, 2022 - Issue
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Original Research

The Age-Specific Features and Clinical Significance of NRF2 and MAPK10 Expression in HCC Patients

Manar Atyah1 Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, People’s Republic of ChinaView further author information
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Chenhao Zhou1 Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-4800-3249View further author information
ORCID Icon,
Qiang Zhou1 Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, People’s Republic of ChinaView further author information
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Wanyong Chen1 Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, People’s Republic of ChinaView further author information
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Jialei Weng1 Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, People’s Republic of ChinaView further author information
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Pengcheng Wang1 Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, People’s Republic of ChinaView further author information
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Yi Shi2 Biomedical Research Centre, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of ChinaView further author information
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Qiongzhu Dong3 Institute of Fudan Minhang Academic Health System, and Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer (SMHC), Minhang Hospital & AHS, Fudan University, Shanghai, 201199, People’s Republic of China;4 Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, People’s Republic of ChinaCorrespondence[email protected]
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Ning Ren1 Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, 200032, People’s Republic of China;3 Institute of Fudan Minhang Academic Health System, and Key Laboratory of Whole-period Monitoring and Precise Intervention of Digestive Cancer (SMHC), Minhang Hospital & AHS, Fudan University, Shanghai, 201199, People’s Republic of ChinaCorrespondence[email protected]
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Pages 737-748 | Published online: 20 Jan 2022

Figures & data

Figure 1 Representative samples of immunohistochemical staining of nucleus (A) weak staining; (B) strong staining) and cytoplasm (C) weak staining; (D) strong staining).

Figure 1 Representative samples of immunohistochemical staining of nucleus (A) weak staining; (B) strong staining) and cytoplasm (C) weak staining; (D) strong staining).

Table 1 Detailed MAPK10 Genetic Mutation Rates in Different Cancers (HCC, Colorectal Cancer, Stomach Cancer, and Pancreatic Cancer) and Age Groups

Figure 2 Survival curves of HCC patients based on MAPK10 and NRF2 expression levels. (A) long-term overall survival curves of high and low MAPK10 expression groups. (B) long-term disease-free survival curves of high and low MAPK10 expression groups. (C) short-term overall survival curves of high and low NRF2 expression groups. (D) short-term disease-free survival curves of high and low NRF2 expression groups. (E) long-term overall survival curves of high and low MAPK10 and NRF2 expression groups.

Figure 2 Survival curves of HCC patients based on MAPK10 and NRF2 expression levels. (A) long-term overall survival curves of high and low MAPK10 expression groups. (B) long-term disease-free survival curves of high and low MAPK10 expression groups. (C) short-term overall survival curves of high and low NRF2 expression groups. (D) short-term disease-free survival curves of high and low NRF2 expression groups. (E) long-term overall survival curves of high and low MAPK10 and NRF2 expression groups.

Table 2 Clinical Characteristics of MAPK10 Protein Expression Groups (181 Patients)

Table 3 Clinical Characteristics of NRF2 Protein Expression Groups (181 Patients)

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