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International Journal of General Medicine Volume 15, 2022 - Issue
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Original Research

Construction of Novel Prognostic Nomogram for Mucinous and Signet Ring Cell Colorectal Cancer Patients with a Survival Longer Than 5 Years

Juan Xu1 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China;2 Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, People’s Republic of ChinaView further author information
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Ziwei Sun1 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China;2 Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0001-7807-2336View further author information
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Huanyu Ju1 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China;2 Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, People’s Republic of ChinaView further author information
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Erfu Xie1 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China;2 Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, People’s Republic of ChinaView further author information
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Yuan Mu1 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China;2 Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, People’s Republic of ChinaView further author information
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Jian Xu1 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China;2 Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-2032-251XView further author information
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Shiyang Pan1 Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China;2 Branch of National Clinical Research Center for Laboratory Medicine, Nanjing, People’s Republic of ChinaCorrespondence[email protected]
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Pages 2549-2573 | Published online: 05 Mar 2022

Figures & data

Figure 1 Flow chart for the creation of the included MA and SRCC patient cohort.

Abbreviations: MA, mucinous adenocarcinoma; SRCC, signet ring cell carcinoma; ST, survival time; Y, year.
Figure 1 Flow chart for the creation of the included MA and SRCC patient cohort.

Table 1 Comparation of Clinical Characteristics of Patients with Different Survival Times

Table 2 Prognostic Factors for the OS and CSS in Patients with a Survival Time Longer Than 5 Years by Univariate Analysis

Table 3 Multivariable Cox Regression Analysis of the Prognosis Factors Associated with OS and CSS in Patients with a Survival Time Longer Than 5 Years

Table 4 Multivariable Cox Regression Analysis of the Prognosis Factors Associated with OS and CSS in Patients with ST<5Y

Figure 2 Kaplan-Meier curves for CSS in MA patients with ST<5Y and ST≥5Y.

Notes: (A, C and E) MA patients with ST<5Y; (A) TNM stage; (C) tumor grade; (E) tumor size. (B, D and F) MA patients with ST≥5Y; (B) TNM stage; (D) tumor grade; (F) tumor size.
Abbreviations: CSS, cancer-specific survival; MA, mucinous adenocarcinoma; ST, survival time; Y, year.
Figure 2 Kaplan-Meier curves for CSS in MA patients with ST<5Y and ST≥5Y.

Figure 3 Kaplan-Meier curves for CSS in SRCC patients with ST<5Y and ST≥5Y.

Notes: (A, C and E) MA patients with ST<5Y; (A) TNM stage; (C) tumor grade; (E) tumor size. (B, D and F) MA patients with ST≥5Y; (B) TNM stage; (D) tumor grade; (F) tumor size.
Abbreviations: CSS, cancer-specific survival; SRCC, signet ring cell carcinoma; ST, survival time; Y, year.
Figure 3 Kaplan-Meier curves for CSS in SRCC patients with ST<5Y and ST≥5Y.

Figure 4 Survival analysis of chemotherapy in MA and SRCC patients with ST<5Y and ST≥5Y.

Notes: (A, C, E and G) Patients with ST<5Y; (B, D, F and H) patients with ST≥5Y; (A and B) overall survival of mucinous adenocarcinoma; (C and D) cancer cause-specific survival of mucinous adenocarcinoma; (E and F) overall survival of signet ring cell carcinoma; (G and H) cause-specific survival of signet ring cell carcinoma cancer.
Figure 4 Survival analysis of chemotherapy in MA and SRCC patients with ST<5Y and ST≥5Y.

Figure 5 Survival benefit of chemotherapy for MAOS in patients with ST≥5Y.

Notes: (A) The whole cohort; (B) patients with primary tumor located in the right colon; (C) patients with primary tumor located in the left colon; (D) patients with primary tumor located in the rectum; (E) patients with stage I; (F) patients with stage II; (G) patients with stage III; (H) patients with stage IV.
Abbreviations: MAOS, overall survival of mucinous adenocarcinoma; ST, survival time; Y, year.
Figure 5 Survival benefit of chemotherapy for MAOS in patients with ST≥5Y.

Figure 6 Construction of nomograms to predict the 10-year OS and CSS probability for MA patients with ST≥5Y.

Notes: (A) Nomogram to predict the OS probability; (B) nomogram to predict the CSS probability.
Abbreviations: MA, mucinous adenocarcinoma; OS, overall survival; CSS, cancer-specific survival; CEA, carcinoembryonic antigen; LN, lymph nodes; RT, radiotherapy; ST, survival time; Y, year.
Figure 6 Construction of nomograms to predict the 10-year OS and CSS probability for MA patients with ST≥5Y.

Figure 7 ROC curves and calibration plots of the nomograms for MA patients with ST≥5Y.

Notes: ROC curves for predicting 10-year OS and CSS of MA patients with ST≥5Y in the training cohort (A and E) and validation cohort (C and G). Calibration plots of the nomogram prediction of 10-year OS and CSS in the training cohort (B and F) and validation cohort (D and H). The diagonal line shows equality between the actual and predicted survival probability.
Abbreviations: MA, mucinous adenocarcinoma; OS, overall survival; CSS, cancer-specific survival; ROC, receiver operating characteristic curve; AUC, areas under the ROC curve; ST, survival time; Y, year.
Figure 7 ROC curves and calibration plots of the nomograms for MA patients with ST≥5Y.

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