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Original Research

Role of Therapeutic Plasmapheresis in SARS-CoV-2 Induced Cytokine Release Syndrome: A Retrospective Cohort Study on COVID-19 Patients

, ORCID Icon, , , & ORCID Icon
Pages 4907-4916 | Published online: 12 May 2022

Figures & data

Figure 1 Patient selection and matching flowchart.

Abbreviations: TPE, therapeutic plasma exchange; CRS, cytokine release syndrome; SC, standard care.
Figure 1 Patient selection and matching flowchart.

Table 1 Table Showing the Comparison of Clinical and Laboratory Profiles of Two Groups of COVID-19 Patients in Relation to Use of Plasmapheresis; Plasmapheresis Plus Standard Care Vs Standard Care Alone. Mean, Standard Deviation and p Value are Used for Expression of Variables

Table 2 Table Showing the Comparison of Lymphocytes, Inflammatory Markers and PaO2/FiO2 Pre- and Post-Plasmapheresis in the Plasmapheresis Plus Standard Care Group Vs Parameters at Time of Admission to the Medical-ICU and During Admission in the Standard Care Alone Group. Mean, Standard Deviation and p Value

Table 3 Table Showing the Comparison of Clinical Outcome in Terms of Different Clinical Parameters (Invasive Ventilation, Rate of Extubation, Mortality and Survival) Among 2 Groups: Plasmapheresis Plus Standard Care Vs Standard Care Alone. Percentages and p Value are Used for Expression of Variables

Figure 2 Kaplan–Meier analysis curve showing that overall survival probability is >75% for group who received therapeutic plasmapheresis plus standard care while survival probability is between 60–65% for patients receiving only standard care. The median survival duration was 24 days for plasmapheresis plus standard care group and 18 days for standard care alone (Log rank x2= 1.06, p=0.30).

Figure 2 Kaplan–Meier analysis curve showing that overall survival probability is >75% for group who received therapeutic plasmapheresis plus standard care while survival probability is between 60–65% for patients receiving only standard care. The median survival duration was 24 days for plasmapheresis plus standard care group and 18 days for standard care alone (Log rank x2= 1.06, p=0.30).

Table 4 Cox Regression Analysis Showing Variables in Predicting Survival of Patients with COVID-19 Complicated by CRS