Morphological and Functional Features in Patients with Idiopathic Macular Hole Treatment

Figures & data

Table 1 Baseline Characteristic of Included Patients

	Patients		Healthy Control (n=30)	P
	IMH Eyes (n=25)	Fellow Eyes (n=30)
Gender (male/female)	3/22	3/22	5/25	0.502
Age (years)	63.80±4	63.80±4.30	61.00±5.80	0.069
BCVA (LogMAR)	1.65±1.19	0.08±0.05	0.06±0.05	<0.001
Duration (days)	86.20±45.36
Macular hole diameter (μm)	608.35±4.30

Abbreviations: IMH, idiopathic macular hole; LogMAR, logarithm of the minimum angle of resolution.

Table 2 Comparison of Multifocal Electroretinogram Parameters of IMH Eyes, Fellow Eyes and Normal Eyes

mfERG Ring		Normal Eyes (N=30)		Fellow Eyes (N=25)			IMH Eyes (N=25)
		Mean	SD	Mean	SD	P*	Mean	SD	P^#
Ring 1	Amplitude	110.01	11.72	124.53	44.51	0.212	53.86	26.95	<0.001
	Implicit time	39.70	0.47	53.53	3.01	0.001	52.10	4.87	<0.001
Ring 2	Amplitude	76.15	4.60	61.40	24.36	0.151	35.41	22.59	<0.001
	Implicit time	39.51	0.53	50.01	1.27	<0.001	51.11	2.12	<0.001
Ring 3	Amplitude	42.80	1.87	41.02	13.17	0.454	26.42	12.90	0.10
	Implicit time	39.28	0.48	48.73	1.43	<0.001	50.08	2.66	<0.001
Ring 4	Amplitude	32.17	2.00	23.55	7.69	0.015	16.62	8.61	<0.001
	Implicit time	39.57	0.67	48.55	1.76	<0.001	49.82	3.58	<0.001
Ring 5	Amplitude	22.56	1.93	16.73	5.78	0.10	12.75	5.94	0.002
	Implicit time	38.63	1.77	47.46	4.65	<0.001	50.16	3.60	<0.001

Notes: *Comparison between fellow eyes and normal eyes. ^#Comparison between IMH eyes and normal eyes.

Abbreviations: IMH, idiopathic macular hole; mfERG, multifocal electroretinogram; SD, standard deviation.

Table 3 Comparisons of SRBFD and CBFD Measurements in Macular Area Between IMH Group, Fellow Eye Group and Healthy Control Group

Region	IMH Eyes (N=25)	Fellow Eyes (N=25)	Normal Eyes (N=30)	P	p-value for IMH Eyes vs Fellow Eyes	p-value for IMH Eyes vs Normal Eyes	p-value for Fellow Eyes vs Normal Eyes
SRBFD (mm^2)	45.79±3.49	48.20±3.90	49.75±3.33	<0.001	0.562	<0.001	0.038
CBFD (mm^2)	0.44±0.07	0.56±0.07	0.59±0.01	<0.001	<0.001	0.002	<0.001

Abbreviations: IMH, idiopathic macular hole; SRBFD, superficial retinal blood flow density; CBFD, choroidal blood flow density.

Table 4 Pre and Post-Surgery (1 Month, 3 Months, and 6 Months) Comparison of Multifocal Electroretinogram (mfERG) Components in IMH Eyes (Mean±SD)

mfERG Ring		IMH Eyes
		Pre-Operation	1 Month	3 Months	6 Months	F value	P
Ring 1	Amplitude	53.86±26.95	74.64±28.87	90.42±28.56	74.83±39.66	6.037	0.006
	Implicit time	52.10±4.87	50.05±7.39	50.35±10.53	51.73±9.91	0.190	0.903
Ring 2	Amplitude	35.41±22.59	23.75±22.93	21.75±4.00	27.37±23.95	1.370	0.288
	Implicit time	51.11±2.12	53.77±4.12	48.88±4.21	52.60±5.11	5.129	0.003
Ring 3	Amplitude	26.42±12.90	12.60±13.09	12.54±11.06	15.78±17.13	8.435	0.007
	Implicit time	50.08±2.66	51.16±3.29	50.26±5.18	50.46±5.64	0.253	0.859
Ring 4	Amplitude	16.62±8.61	8.75±7.77	7.89±6.67	11.17±9.71	6.686	0.001
	Implicit time	49.82±3.58	52.22±3.20	51.25±2.65	52.33±3.91	2.542	0.066
Ring 5	Amplitude	12.75±5.94	6.21±4.51	5.83±4.18	7.74±7.46	8.938	0.005
	Implicit time	50.17±3.60	53.59±3.34	50.76±3.27	50.95±4.39	4.016	0.012

Abbreviations: IMH, idiopathic macular hole; SD, standard deviation; mfERG, multifocal electroretinogram.

Table 5 Correlation Between Visual Acuity in logMAR and Multifocal Electroretinogram (mfERG) Components Before and After Surgery in IMH Eyes and in the Fellow Eyes

mfERG Ring		IMH Eyes Pre Surgery (n=25)		IMH Eyes Post-Surgery (6 Months, n=25)		Fellow Eyes (n=25)
		r value	P	r value	P	r value	P
Average	Amplitude	−0.708	0.180	−0.320	0.559	0.07	0.346
	Implicit time	−0.550	0.337	−0.890	0.043	−0.370	0.015
Ring 1	Amplitude	−0.294	0.221	−0.004	0.987	0.020	0.934
	Implicit time	0.106	0.667	−0.061	0.809	0.192	0.431
Ring 2	Amplitude	−0.242	0.318	0.082	0.747	−0.203	0.404
	Implicit time	−0.073	0.768	−0.021	0.935	0.344	0.059
Ring 3	Amplitude	−0.040	0.870	0.065	0.798	−0.165	0.499
	Implicit time	−0.002	0.992	−0.027	0.915	0.117	0.634
Ring 4	Amplitude	−0.141	0.565	0.016	0.950	−0.114	0.642
	Implicit time	−0.097	0.694	0.270	0.279	0.113	0.646
Ring 5	Amplitude	−0.176	0.471	−0.108	0.670	−0.068	0.781
	Implicit time	−0.192	0.430	−0.510	0.031	−0.147	0.515

Abbreviations: IMH, idiopathic macular hole; LogMAR, logarithm of the minimum angle of resolution; mfERG, multifocal electroretinogram; SD, standard deviation.

Table 6 Pre and Post-Surgery (1 Month, 3 Months, and 6 Months) Comparison of SRBFD and CBFD in Eyes with IMH (Mean±SD)

Region	Blood Flow Density				P
	Pre-Operation	1 Month	3 Months	6 Months
SRBFD (mm^2)	45.19±0.64	46.35±0.95	47.91±0.75	43.56±0.98	<0.001
CBFD (mm^2)	0.44±0.08	0.49±0.13	0.51±0.14	0.53±0.15	0.002

Abbreviations: IMH, idiopathic macular hole; BFD, blood flow density; SRBFD, superficial retinal blood flow density; CBFD, choroidal blood flow density.